Heterocyclic N-oxides are ubiquitous protecting groups, auxiliary agents, oxidants, catalysts, surrogates for heterocyclic boronic acids or ligands in metal complexes. In addition, pyridine N-oxide derivatives have been recently reported to represent a new class of anti-HIV compounds. In this NJC letter, Wei Zhao and Chunxia Yang (Nanyang Normal University, China) report an effective and green procedure for pyridine oxidation using the large Δ-Na8HPW9O34 polyoxometalate as catalyst. In this system, reactions were carried out in water at room temperature with hydrogen peroxide as oxidant. The catalyst could be recovered and reused several times without obvious loss of activity.
“A green catalytic procedure for oxidation of pyridines catalyzed by a lacunary polyoxometalate in water at room temperature” Wei Zhao and Chunxia Yang, New J. Chem., 2013, Advance Article. DOI: 10.1039/C3NJ00149K (Letter).
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