In their NJC paper, Mark G. Moloney and co-workers (University of Oxford, UK) showed that derivatisation of polystyrene by carbene insertions followed by diazonium coupling provides access to materials with similar bulk properties, but with various surface chemical characteristics. The controlled modification of chemical functionality at the surface results in changes in macroscopic polymer behaviour such as wettability and protein binding. These results are of immediate relevance for the design of new biomaterial and drug delivery devices.
“Post-polymerisation modification of surface chemical functionality and its effect on protein binding” Cleo Choong , J. S. Foord , Jon-Paul Griffiths , Emily M. Parker , Luo Baiwen , Meghali Bora and Mark G. Moloney, New J. Chem., 2012, Advance Article.DOI: 10.1039/C2NJ00002D.
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