RSC Mechanochemistry Blog

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Hanusa about their study titled Grinding and the anisotropic environment: influences on the diastereoselective formation of Group 15 allyl complexes.

“The environment in a mechanochemically driven reaction is often considered chaotic and random, whether it’s from the pelting of stainless-steel balls or the effect of collisions in resonant acoustic mixing (RAM). So, the possibility of studying a mechanochemical environment that is less than homogenous—that has anisotropic features—is particularly attractive.”

“In this research, we revisited a system we had studied a few years ago, which involved organometallic diastereomers formed either in solution or mechanochemically. In the case of arsenic and antimony complexes with bulky allyl ligands, a greater percentage of the asymmetric form was generated during mechanochemical synthesis. The difference was traced to the use of layered starting reagents, specifically AsI₃ and SbCl₃, and their directing effect on compound formation. In solution, the anisotropic environment is lost, and a larger amount of the more symmetric diastereomer is formed, owing to the quasi-spherical environments around the As³⁺ and Sb³⁺ ions.”

“The current study expanded the range of reagents and mechanochemical variables used to synthesize the diastereomers. The aim was to determine their effect on the diastereomer ratios, yields, and formation of decomposition products. When liquid AsCl₃ was used in place of the layered, solid AsI₃, the diastereomer ratio of the arsenic complex not surprisingly veered toward solution values. However, the strong effect of liquid-assisted grinding (LAG) was unexpected. LAG altered the diastereomer ratio toward solution values, even when minimal amounts of solvents were added, and the reagents had negligible solubility in the added solvent.”

“These results indicate that the anisotropic environment can be meaningfully manipulated in the solid state. Since it is a variable with no direct solution counterpart, such as the time or temperature of the reaction, its expanded use holds promise for new outcomes from mechanochemically initiated synthesis.”

Want to know more about their work? Read the full paper here!

Grinding and the anisotropic environment: influences on the diastereoselective formation of Group 15 allyl complexes

Lauren E. Wenger and Timothy P. Hanusa

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D4MR00001C

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Masad Damha, James Thorpe and Julian Marlyn about their study titled Synthesis of short DNA and RNA fragments by resonant acoustic mixing (RAM).

Want to know more about their work? Read the full paper here!

Synthesis of short DNA and RNA fragments by resonant acoustic mixing (RAM)

James D. Thorpe, Julian Marlyn, Stefan G. Koenig and Masad J. Damha

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D4MR00009A

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Michel Baltas, Christina Koumpoura, Christian Bijani and Laure Vendier about their study titled Unprecedented linear products by a mechanochemically activated Biginelli reaction using lawsone.

Want to know more about their work? Read the full paper here!

Unprecedented linear products by a mechanochemically activated Biginelli reaction using lawsone

Christina L. Koumpoura, Laure Vendier, Christian Bijani, Anne Robert, Philippe Carbonnière, Jean-Marc Sotiropoulos and Michel Baltas

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D3MR00032J

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Dzmitry Kananovich, Riina Aav and co-workers about their study titled Protecting-group-free mechanosynthesis of amides from hydroxycarboxylic acids: application to the synthesis of imatinib.

Want to know more about their work? Read the full paper here!

Protecting-group-free mechanosynthesis of amides from hydroxycarboxylic acids: application to the synthesis of imatinib

Tatsiana Nikonovich, Tatsiana Jarg, Jevgenija Martõnova, Artjom Kudrjašov, Danylo Merzhyievskyi, Marina Kudrjašova, Fabrice Gallou, Riina Aav and Dzmitry Kananovich

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D4MR00006D

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Matteo Martelli, Lucia Maini and Marianna Marchini about their study titled “What makes every work perfect is cooking and grinding”: the ancient roots of mechanochemistry.

Want to know more about their work? Read the full paper here!

“What makes every work perfect is cooking and grinding”: the ancient roots of mechanochemistry

Marianna Marchini, Giacomo Montanari, Lucia Casali, Matteo Martelli, Lucia Raggetti, Matej Baláž, Peter Baláž and Lucia Maini

RSC Mechanochem. 2024, 1, 123-129, DOI: 10.1039/D3MR00035D

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Shunsuke Tanaka about their study titled “Wash-free” synthesis of cyclodextrin metal–organic frameworks.

Want to know more about their work? Read the full paper here!

“Wash-free” synthesis of cyclodextrin metal–organic frameworks

Shuhei Fujita, Kazunori Kadota, Atsushi Koike, Hiromasa Uchiyama, Yuichi Tozuka and Shunsuke Tanaka

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D3MR00006K

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Ryan Kwok about their study titled Kinetics of primary mechanochemical covalent-bond-forming reactions.

Want to know more about their work? Read the full paper here!

Kinetics of primary mechanochemical covalent-bond-forming reactions

Yerzhan S. Zholdassov, Ryan W. Kwok, Milan A. Shlain, Monil Patel, Mateusz Marianski and Adam B. Braunschweig

RSC Mechanochem. 2024, 1, 11-32, DOI: 10.1039/D3MR00018D

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media

RSC Mechanochemistry has published its first articles. To celebrate this, we asked the authors to discuss their work in some more detail.

In this edition, we hear from Matej Baláž about their study titled Mechanically induced self-propagating reactions (MSRs) to instantly prepare binary metal chalcogenides: assessing the influence of particle size, bulk modulus, reagents melting temperature difference and thermodynamic constants on the ignition time.

Want to know more about their work? Read the full paper here!

Mechanically induced self-propagating reactions (MSRs) to instantly prepare binary metal chalcogenides: assessing the influence of particle size, bulk modulus, reagents melting temperature difference and thermodynamic constants on the ignition time

Matej Baláž, Róbert Džunda, Radovan Bureš, Tibor Sopčák and Tamás Csanádi

RSC Mechanochem. 2024, Advance Article, DOI: 10.1039/D3MR00001J

RSC Mechanochemistry offers you an inclusive and dedicated home for the ideas, scientific language and approaches that cut across the many disciplines mechanochemistry touches. Here we are seeking to build knowledge, as well as foster innovation and discovery at this forefront of chemistry. Whether you are seeking to understand the fundamentals of mechanochemistry, or you are excited by its applications and potential, this journal is for you.   Find out more about the journal Read our published articles Submit your manuscript today Sign up for email alerts Follow us on social media