Archive for the ‘Editors Choice’ Category

Editors’ Choice: Structure-guided design of a selective BCL-XL inhibitor

This article describes the structure-guided optimisation of a screening hit against the pro-survival protein BCL-XL, which is often overexpressed in solid tumors and results in malignant tumor cells showing resistance to anticancer treatments.

Structure-guided design of a selective BCL-XL inhibitor
Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus J A Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David C S Huang and Keith G Watson
Nature Chemical Biology, 9, 390–397, (2013)

Editors’ Choice articles are articles identified as being of high potential interest to medicinal chemists, selected from the wider literature by members of the Editorial Board.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Editors’ Choice: Target validation using chemical probes

In this commentary article, Mark Bunnage and colleagues propose that by developing a ‘chemical probe tool kit’, chemical biology can play a more important part in seeking out potentially relevant targets.

Target validation using chemical probes
Mark E Bunnage, Eugene L Piatnitski Chekler & Lyn H Jones
Nature Chemical Biology, 9, 195–199 (2013)

Editors’ Choice articles are articles identified as being of high potential interest to medicinal chemists, selected from the wider literature by members of the Editorial Board.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)