Shrinking Lab-on-a-Chip to Lab-in-a-Tube

Throughout a series of Lab on a Chip Focus Articles Samuel Sánchez, research group leader at Max Planck Institute for Intelligent Systems and recently elected as “innovator of the year 2014”, will be highlighting cutting-edge reports based on miniaturized devices that bridge functional materials and bio-related applications. And first up we have…Lab-in-a-Tube!

Lab-on-a-chip already scales down several components and integrates them into one device, but now scientists are working toward shrinking this further to develop entire laboratories inside an ultra-compact architecture such as a small tube. Samuel discusses the concept and advantages of the lab-in-a-tube before highlighting remarkable cell studies that have already been performed using microtubes.

Lab-in-a-tube systems can combine several functionalities such as optical or electrochemical sensing and is therefore used in various detection systems. Samuel describes the developments in this area, leading to the fabrication of a highly sensitive rolled-up optofluidic ring resonator – fully integrated into lab-on-a-chip devices of course!

Label-free detection systems using the lab-in-a-tube concept

Finally, Samuel discusses the challenges of controlling fluid flow at the micro scale and the use of self-powered on-chip micropumps. As one of Samuel’s main interests, catalytic micropumps will be discussed further in an upcoming Focus Article.

Samuel’s full article ‘Lab-in-a-tube systems as ultra-compact devices’ can be downloaded for free* on our website. We hope you enjoy reading his summary of recent advances in this new and exciting concept of chip integration.

Don’t miss Samuel’s next focus article – register for our e-alerts now!

*Access is free through a publishing personal account. It’s quick, easy and free to register.

More about Samuel Sánchez

Samuel earned his PhD in Analytical Chemistry from the Autonomous University of Barcelona in 2008. After a short period as an Assistant Professor, he worked in Japan at the National Institute for Materials Science. In 2010 he moved to the Institute for Integrative Nanoscience at the Leibniz Institute in Dresden where he was leading the “Biochemical Nanomembranes” group. He is now leading the independent research group at the Max Planck Institute for Intelligent Systems. Samuel has received several awards for his work including the Guinness World Record® for “The smallest man-made jet engine” in 2010, the IIN-IFW Research Prize 2011, the ERC-Starting Grant 2012 “Lab-in-a-tube and Nanorobotic Biosensors (LT-NRBS).” Recently, Samuel has been named as Spain’s top innovators under 35 by the Spanish edition of the journal MIT Technology Review.

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October’s HOT Free Articles

These HOT articles, published in October 2014 were recommended by our referees and are free* to access for 4 weeks

Optofluidic lasers with a single molecular layer of gain
Qiushu Chen, Michael Ritt, Sivaraj Sivaramakrishnan, Yuze Sun and Xudong Fan
Lab Chip, 2014,14, 4590-4595
DOI: 10.1039/C4LC00872C, Communication

A self-powered one-touch blood extraction system: a novel polymer-capped hollow microneedle integrated with a pre-vacuum actuator
Cheng Guo Li, Manita Dangol, Chang Yeol Lee, Mingyu Jang and Hyungil Jung
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00937A, Paper


Design of a 2D no-flow chamber to monitor hematopoietic stem cells
Théo Cambier, Thibault Honegger, Valérie Vanneaux, Jean Berthier, David Peyrade, Laurent Blanchoin, Jerome Larghero and Manuel Théry
Lab Chip, 2015,15, 77-85
DOI: 10.1039/C4LC00807C, Paper


Take a look at our Lab on a Chip 2014 HOT Articles Collection!

*Access is free until 5.01.14 through a publishing personal account. It’s quick, easy and free to register!

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Femtofluidic droplet manipulation now possible

a ChemistryWorld article by Megan Tyler

We’ve had microfluidics. We’ve even had nanofluidics. But now, scientists have gone a step smaller by pushing femtofluidics into the realms of possibility.

Droplet microfluidics enables assays and reactions to be performed in droplets of reagent that are just a few nanolitres or picolitres in volume. The main advantages of this are that reactions can be performed in a massively parallel manner using hardly any reagent, and further miniaturisation to give femtolitre droplets promises to enable even higher-throughput with even lower reagent use.

Please visit ChemistryWorld to read the full article .

Droplet-based microfluidics at the femtolitre scale*
Marie Leman, Faris Abouakil, Andrew D. Griffiths and Patrick Tabeling
Lab Chip
, 2015, Advance Article
DOI: 10.1039/C4LC01122H

*Access is free through a registered RSC account until 13 November 2014 – click here to register

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New YouTube Videos

Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage 

  

Development of the centrifugal multiplex RT-LAMP—ICS microdevice for influenza A virus subtyping 
   

Microfluidic Continuous Flow Digital Loop-Mediated Isothermal Amplification (LAMP) 

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Dancing Magnetotactic Bacteria wins the 2014 microTAS Video Competition

Researchers teach bacteria to line dance!

Lab on a Chip congratulates Tijmen Hageman and colleagues, winners of the first μTAS Video Competition, created in partnership with Dolomite Microfluidics and supported by the CBMS (the Chemical and Biological Microsystems Society).

At the μTAS conference in October 2014 Lab on a Chip Executive Editor, Harpal Minhas (above left) and  Dolomite Microfluidics Group Chief Sales Officer, Omar Jina (above right) presented Tijmen (above middle) with his award and a $2500 gift certificate to spend on dolomite equipment.

Prior to the conference, μTAS participants were invited to submit short, scientifically or educationally focused videos. The winning group, a collaboration of researchers from the University of Twente and the Korean Institute of Science and Technology produced a video demonstrating that bacteria can be manipulated by a magnetic field by using magnets to teach bacteria to line dance – and it looks like they had a lot of fun during the making!

Watch ‘Line Dancing Magnetotactic Bacteria‘ online now!


Ph.D student, Tijmen Hageman directed the video titled ‘Magnetotactic Bacteria.’

“The idea of dancing bacteria existed for some time already, and we decided to make it all in the style of Texas. We think we succeeded in introducting these extraordinary organisms to the public in a remarkable way and hope it will have made our research more visible,” he explains.

Like many studens, Tijmen is currently undecided about what to do after completion of his Ph.D. “I have some years left, and who knows…more videos prehaps” he says.

Tijmen can not take full credit for the winning video and we would also like to congratulate the following for their contribution:

Andreas Manz: Actor (bacteria)

Tijmen Hageman: Actor, director

Marc Pichel: Writer/ideas, cultivation

Caspar Abelmann: Animations

Line dancers: Ahyeon Gyeon, Jaewon Hwang, Jang Mi, Sangin Park, Jooyoung Im, Deepti Mittal, Marc Pichel and Tijmen Hageman

And the rest of the team for ideas and feedback!

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New YouTube Videos

A microfluidic device and automatic counting system for the study of C. elegans reproductive aging  

 
High-throughput Mapping of Brain-wide Activity in Awake and Drug-responsive Vertebrates  

 
Microfluidic cellular enrichment and separation through differences in viscoelastic deformation  

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The Sphere wins the 2014 Art in Science Competition

Congratulations to David Castro, winner of Under the Looking Glass: Art from the World of Small Science, sponsored by NIST and Lab on a Chip.

The winning photograph for the seventh annual art in science competition was announced last week at the µTAS 2014 Conference. The research group, from the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia were presented with a certificate and a financial reward. Their photograph will be featured on the cover of an upcoming issue of Lab on a Chip. Make sure you don’t miss it – register for our e-alerts now!

And the winning photograph is… THE SPHERE

More about ‘The Sphere’

Photographed by David Castro and David Conchouso, is the top view of a rotating 40uL aqueous droplet, suspended at the interface between two fluids, inside a square cuvette. The droplet contains an assay of functionalized latex beads, agglutinating in the presence of human C-reactive protein. This entry was selected as the winning photograph due to its aesthetic eye appeal, artistic allure and scientific merit.

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New YouTube Videos

Design of a 2D no-flow chamber to monitor hematopoietic stem cells

Multiplexed Fluidic Plunger Mechanism for the Measurement of Red Blood Cell Deformability

A droplet-to-digital (D2D) microfluidic device for single cell assays

Self-Powered One-Touch Blood Extraction System: Novel Polymer-Capped Hollow Microneedle Integrated with Pre-Vacuum Actuator

A Quantitative Microfluidic Angiogenesis Screen for Studying Anti-Angiogenic Therapeutic Assay

Inducing microscopic thermal lesions for the dissection of functional cell networks on a chip

Electrokinetic Study on 3D Nanochannel Networks Constructed by Spatially Controlled Nanoparticle Assembly

Droplet microfluidic system for sequential generation of lipid bilayers and transmembrane electrical recordings

A Siphonage Flow and Thread-based Low-cost Platform Enables Quantitative and Sensitive Assay

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Lectureship presented to Sangeeta Bhatia

Congratulations to Dr. Sangeeta N. Bhatia, winner of  the 2014 Corning Inc./Lab on a Chip Pioneers of Miniaturisation Lectureship.


The picture shows Lab on a Chip Executive Editor, Harpal Minhas (Left) and Director of Polymer processing in Organic & Biochemical Technologies, Science & Technology at Corning Incorporated, Ed Fewkes (right) presenting Sangeeta (middle) with her award earlier this week at the µTAS 2014 Conference.

The 9th ‘Pioneers of Ministurisation‘ Lectureship, is for extraordinary or outstanding contributions to the understanding or development of miniaturised systems and was presented to Dr Bhatia at the µTAS 2014 Conference in San Antonio, Texas in October 2014. Dr Bhatia received a certificate, $5000 and gave a short lecture at the conference. Further information, including past winners, can be viewed on our homepage.

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September’s HOT Free Articles

These HOT articles, published in September 2014 were recommended by our referees and are free* to access for 4 weeks

1000-fold sample focusing on paper-based microfluidic devices
Tally Rosenfeld and Moran Bercovici
Lab Chip, 2014,14, 4465-4474
DOI: 10.1039/C4LC00734D

A reliable and programmable acoustofluidic pump powered by oscillating sharp-edge structures
Po-Hsun Huang, Nitesh Nama, Zhangming Mao, Peng Li, Joseph Rufo, Yuchao Chen, Yuliang Xie, Cheng-Hsin Wei, Lin Wang and Tony Jun Huang
Lab Chip, 2014,14, 4319-4323
DOI: 10.1039/C4LC00806E

Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering
Siwei Li, Peter Glynne-Jones, Orestis G. Andriotis, Kuan Y. Ching, Umesh S. Jonnalagadda, Richard O. C. Oreffo, Martyn Hill and Rahul S. Tare
Lab Chip, 2014,14, 4475-4485
DOI: 10.1039/C4LC00956H


Take a look at our Lab on a Chip 2014 HOT Articles Collection!

*Access is free until 28.11.14 through a publishing personal account. It’s quick, easy and free to register!

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