Archive for the ‘Uncategorized’ Category

Welcome to our newest Lab on a Chip Associate Editors in 2023!

 

We are delighted to welcome:

  • Professor Xingyu Jiang (SUSTech, China)
  • Professor Amy Herr (UC Berkeley, USA)
  • Professor Hongkai Wu (HKUST, Hong Kong)

as our newest Lab on a Chip Associate Editors! You can read more about them and their research focus below.

 


Amy Herr

John D. & Catherine T. MacArthur Professor, Department of Bioengineering, 

University of California,  Berkeley, USA

Amy Herr is the John D. & Catherine T. MacArthur Professor in the Department of Bioengineering , a Chan Zuckerberg (CZ) Biohub Investigator, and CTO of the Chan Zuckerberg Biohub Network.

A major focus of the Herr lab is engineering innovation for analysis of complex biological systems — as is required to address questions important to both fundamental biological systems and applied clinical research. They employ a combination of approaches drawn from chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, materials science, and analytical chemistry.  In essence, they strive to advance the “mathematization” of biology & medicine.  Their research projects span understanding fundamental transport to materials design to applications in life sciences tools and diagnostics.

Professor Herr’s research has been recognized by prominent international andnational organizations, including: 2018 Sciex Microscale Separations Innovation Medal, 2017 Georgina Sweet Lectureship from the Australian Research Council, 2016 Mid-career Achievement Award from the American Electrophoresis Society, 2015 Georges Guiochon Faculty Fellow from HPLC, 2012 Young Innovator Award from Analytical Chemistry/CBMS, 2011 NSF CAREER award, 2010 NIH New Innovator Award, 2010 Alfred P. Sloan Research Fellowship in chemistry, 2010 New Investigator Award in Analytical Chemistry from Eli Lilly & Co., and a 2009 Defense Advanced Research Projects Agency (DARPA) Young Faculty Award. Her commitment to creating a strong professional community is reflected in recognition as: 2019 Award for Excellence in Postdoctoral Mentoring, Visiting Scientist & Posdoc. Assoc. at UC Berkeley, 2017 Berkeley Visionary Award from the City of Berkeley Chamber of Commerce, and 2007 Outstanding Mentor Award from Sandia National Labs.

Research Expertise and Interest
microfluidics, bioanalytical separations, diagnostics, electrokinetic transport, engineering design

Find out more on the Herr Lab website – Bioinstrumentation for Quantitative Biology & Medicine

Here are a selection of Amy’s most recent Lab on a Chip papers below:


Xingyu Jiang

Chair Professor, Department of Biomedical Engineering                                                                                                                                                                         Southern University of Science and Technology, China

Xingyu Jiang is a Chair Professor at the Southern University of Science and Technology, Shenzhen, China. He obtained his BS at the University of Chicago (1999) and PhD at Harvard University (Chemistry, 2004). In 2005, he joined the National Center for NanoScience and Technology/the University of the Chinese Academy of Sciences. He moved to the Southern University of Science and Technology in 2018. His research interests include microfluidics and nanomedicine and their applications in diagnostics, screening for therapeutics, as well as engineered tissues. He has over 300 publications in peer-reviewed journals. He was awarded the “Hundred Talents Plan” of the Chinese Academy of Sciences, the National Science Foundation of China’s Distinguished Young Scholars Award, the Scopus Young Researcher Gold Award, and the Human Frontier Science Program Young Investigator Award. He is a Fellow of the Royal Society of Chemistry (UK) and the American Institute of Medical and Biological Engineering.

Xingyu has been a committed member of the Lab on a Chip Editorial Board since 2020, and will now start handling papers for the journal.

Research Expertise and Interest
microfluidics & nanomedicine, and their applications in diagnostics, screening for therapeutics,  engineered tissues

Find out more on the Jiang lab website and follow @xingyu on Twitter

Here are a selection of Xingyu’s most recent Lab on a Chip papers below:


Hongkai Wu

Professor,  Department of Chemistry, Department of Chemical & Biological Engineering

Hong Kong University of Science and Technology, Hong Kong

Hongkai Wu is a Professor in Department of Chemistry & Department of Chemical & Biological Engineering at the Hong Kong University of Science and Technology, Hong Kong, China. Dr. Wu received his BSc from University of Science and Technology of China in 1995 and Ph.D from Harvard University, USA in 2002. After working as a Postdoctoral Fellow at Stanford, he joined the faculty in Department of Chemistry in Tsinghua University, Beijing, China in 2005 and moved to HKUST as an Assistant Professor in 2007. In 2012, he was promoted to be an Associate Professor. From 2009 to 2015, he established a satellite laboratory in Tohoku University, Sendai, Japan, focusing on developing functional biomaterials.

Research at the Wu lab focuses on the interdisciplinary frontiers of microfluidics, bioanalytical science and materials chemistry. They use the technologies in MEMS, microfluidics, soft lithography, and surface chemistry to design and provide new tools for the applications and understanding of fundamentals in materials and biological sciences, including microfluidic chemical reactors, high throughput single-cell analysis and chemical separations.

Research Expertise and Interest
microfluidics, bioanalytical science, materials chemistry, single-cell analysis

Find out more on the Wu lab website 

Here are a selection of Hongkai’s Lab on a Chip papers below:


Please join us in welcoming our new Associate Editors. We look forward to continuing to work with them on Lab on a Chip, and they are looking forward to handling your papers!

Submit your paper today!

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Andreas Manz – pioneer, mentor, friend

The founding Editor of Lab on a Chip and pioneer of the µTAS field, Professor Andreas Manz, has announced his retirement. In celebration of all his works and achievements, we have collated a video from his friends and colleagues across the lab on a chip community. 

Watch the video ⬇️

 

We have created a retrospective collection across the past 2 decades since Lab on a Chip’s inception, of his work published in the journal, which can be found here:

Andreas Manz Special Collection

In addition, we will be honouring Andreas with a special Lab on a Chip collection with invited papers from his networks throughout his career, for publication next year. Keep an eye on our Twitter for more details

Please join us in congratulating Andreas on his retirement, and we thank him for all his vital contributions to the journal, the field and the community!

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Welcoming our new Associate Editor, Jean-Christophe Baret

We are delighted to welcome Professor Jean-Christophe Baret as an Associate Editor for Lab on a Chip!


Jean-Christophe Baret

University of Bordeaux , France

JC Baret is Professor at the University of Bordeaux and member of the Institut Universitaire de France. He obtained his PhD from the University of Twente (NL) in 2005 and joined the Institut de Science et d’Ingénierie Supramoléculaires (Univ Strasbourg) as a post-doc and then the Max Planck Institute for Dynamics and Self-Organization in Goettingen as a Max Planck Group Leader.

His laboratory is now located at the CNRS Centre de Recherche Paul Pascal where he develops research activities centered on microfluidics for applications in biochemistry, high-throughput screening and more recently for the bottom-up assembly of artificial cells. He is founder and scientific advisor of Emulseo developing industrial formulations for microfluidics.

Find out more on the his group website and follow @BaretJc on Twitter

Submit your work to Jean-Christophe today!

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Dolomite Microfluidics Competition 2022

Transform microfluidics industry with your research

Dolomite Microfluidic Competition 2022 is a competition for all researchers, students who are working or studying on microfluidics projects across the globe. We know scientists around the world may have many great ideas, but don’t have enough resources for their projects. Therefore, Dolomite Microfluidics would like to organize this competition to bring your ideas to the world and make them come true. – 

Prize

  • 1st Prize:  A virtual voucher to purchase Dolomite Microfluidics products up to a maximum value of USD 6000 (including shipping fee)
  • 2nd Prize:  A virtual voucher to purchase Dolomite Microfluidics products up to a maximum value of USD 2500 (including shipping fee)

The Dolomite Applications team will suggest of the most suitable products for the winner to benefit from in their project based only on the products produced and available on Dolomite Microfluidic Webshop.

Entry period

00:01 am GMT +7 on September 12, 2022 and ends at 11:59 pm GMT +7 on October 31, 2022

How to submit?

Visit the Dolomite Scientific Competition to learn more about the competition, how to submit, and FAQS

Dolomite Scientific Competition 2022_Terms Conditions

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A new look at the world of membranes

Where life begins, the matter is structured at the micron scale by slotting every single molecule into its needful space. The molecules looped a bilipid membrane and nested more functional molecules inside, controlling the flows of energy in that smallest living cell. Every loop is a thicket of surprises on how much life can accomplish. High-precision measurements are a way to go to explore these small loops with immense information.   

A cell requires the bilipid membrane to keep its functional molecules inside and separate itself from the surrounding environment. Bilipid membrane is a thin and flexible film made of water repellent and attractant molecules that form double layers in watery solutions where the water attractant heads line up outside and water repellent tails stay inside. Conditions on the two sides of a bilipid membrane (so, inside and outside of a cell) are often different because the presence and concentrations of surrounding ions and molecules will be different. Although the law of thermodynamics tries to equilibrate the conditions, ion pumps and proteins embedded in bilipid membranes pump molecules and ions in and out, in order to get the cell what it needs. We need a precise understanding of the nature of bilipid membranes to understand life, survival, and producing e.g., pharmaceuticals for survival or better living. Currently, multiple methodologies allow looking at a single cell or single chemical process step level. However, not that many allow analyzing the same phenomena with the same precision from different perspectives. 

Voltage-dependent ion channels are a prominent example of the interest in an efficient methodology for multiple measurements. In essence, they allow for recording the electrical signals that surge as a response to activation of voltage-dependent channels, combined with simultaneous optical observation of structural changes and membrane dynamics. It is not a novel idea in the research world; however, reaching this goal has been challenging. Multiple methodologies have been proposed and tested, but frequently at a cost of a loss of precision or a rise in system complexity, making it hard to handle and more prone to error. The work published by Tobias Ensslen and Jan C. Behrends proposes a gracious solution that with a simple in-concept modification can achieve high optical resolution fluorescence microscopy while using a modified routinely used multielectrode-cavity array (MECA) (Figure 1). 

While taking the original MECA design, a platform used for electrophysiological recordings for artificially formed lipid bilayers, a few alterations were implemented in order to accommodate the fluorescence imaging. The original device was designed with several novelties: (1) Silver/silver chloride electrodes and a gold conductive layer were used for detecting electrical signals emitted by an activated membrane. (2) The substrate for the fabricated system is coverslip glass instead of a microscope slide glass, which decreases the photons’ optical path from 500 µm to <170 µm. (3) The bottom electrodes were changed from a circular shape to a ring one, leaving a central opening for the light path. (4) The MECA-opto platform is also equipped with four apertures for membrane formation, which allow quickly switching the recording if a membrane is damaged or photobleaching in the recording site occurs. Altogether, these modifications enabled the acquisition of individually addressable electrophysiological and optical data without any additional equipment. 

As a proof of concept study, the group demonstrated the molecular process of opening the voltage-dependant ion channel on the given membrane when activated by an antibacterial peptide, ceratotoxin-A. MECA-opto recordings allowed to determine the lifetimes of fluorophores with the results consistent with the available data regarding the stability of fluorophores. This is a promising work that can advance many studies at the molecular level and our understanding of the mechanisms of opening and closing ion channels. 

 

Figure 1. The MECA-Opto device can combine both electrophysiological and optical recordings to monitor free-standing membranes and membrane proteins.

To download the full article for free* click the link below:

A chip-based array for high-resolution fluorescence characterization of free-standing horizontal lipid membranes under voltage clamp

Tobias Ensslen and Jan C. Behrends

Lab Chip, 2022, DOI: 10.1039/d2lc00357k

About the Web writers

OksanaSavchakOksana Savchak is a Ph.D. student in Biosensors and Devices Lab at the Eindhoven University of Technology in the Netherlands. She focuses on the development of microfluidic screening platforms to investigate cell-material interactions.

Burcu Gumuscu is an assistant professor at Eindhoven University of Technology in the Netherlands, and the chair of the Biosensors and Devices Lab. She strives for the development, fabrication, and application of smart biomaterials to realize high-precision processing in high-throughput microfluidic settings. She specifically focuses on the design and development of lab-on-a-chip devices containing hydrogels for diversified life sciences applications.

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Lab on a Chip is sponsoring Acoustofluidics 2022 in Glasgow, 19-21 October

Lab on a Chip is very pleased to be sponsoring and attending Acoustofluidics 2022, taking place 19-21 October 2022 in Glasgow, Scotland.

This focused meeting is dedicated to exploring the science, engineering, and use of micro- to nanoscale Acoustofluidics.

Announced Keynote Speakers
David Weitz (Harvard Univ.)
Bruce Drinkwater (Univ. of Bristol)
Jürg Dual (ETH Zürich)
Eleanor Stride (Univ. of Oxford)

In particular, the scope of the conference includes but is not limited to:

1. Devices

  • Transducer Fabrication
  • Integrated System
  • Lab-on-a-Chip
  • Thin Film and Flexible Acoustofluidics
  • Theory and/or Simulation
  • Other

2. Applications

  • Environment
  • Biology
  • Medicine
  • Energy
  • Theory and/or Simulation
  • Other

3. Manipulation, Transport and Control

  • Acoustic Manipulation
  • Liquid Transport, Jetting and Nebulisation
  • Bubble and Cavity Acoustics
  • Control Schemes
  • Theory and/or Simulation
  • Other

4. Physics

  • New Phenomena and Mechanisms
  • Acoustic Fields and Streaming
  • Acoustic Thermal Effects and Energy
  • Fluid-Structure Interactions
  • Theory and/or Simulation
  • Other

 

Abstract Deadline
Sunday, 31 July 2022

Find out more and register at acoustofluidics.net

 

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A warm welcome to our new Lab on a Chip Advisory Board members

We are delighted to welcome Professors Keisuke Goda, Sindy Tang & Yi-Chin Toh to the Lab on a Chip Advisory Board.


Keisuke Goda

Professor, Department of Chemistry

University of Tokyo, Japan

Keisuke Goda is a professor in the Department of Chemistry at the University of Tokyo, an adjunct professor in the Institute of Technological Sciences at Wuhan University, and an adjunct professor in the Department of Bioengineering at UCLA. He obtained his B.A. from UC Berkeley summa cum laude in 2001 and his Ph.D. from MIT in 2007, both in physics. At MIT, he worked on the development of gravitational-wave detectors in the LIGO group which led to the 2017 Nobel Prize in Physics. After several years of work on high-speed imaging and microfluidics at Caltech and UCLA, he joined the University of Tokyo as a professor. His research group focuses on the development of serendipity-enabling technologies based on molecular imaging and spectroscopy together with microfluidics and computational analytics to push the frontier of science. He currently leads Serendipity Lab, a global network of scientists who aim to realize Louis Pasteur’s statement “Chance favours the prepared mind”. He has published >300 papers, filed >30 patents, and received numerous awards and honours such as Japan Academy Medal and JSPS Prize. He is a fellow of RSC and SPIE.

Keisuke was the recipient of the Lab on a Chip & Dolomite Pioneers of Miniaturization Lectureship Award 2021, and is a Thought Leader for our on-going AI in Microfluidics thematic collection.

Find out more on the GODA LAB website and follow @ut_godalab on Twitter

Here are a selection of Keisuke’s Lab on a Chip papers below:


Sindy Tang

Associate Professor of Mechanical Engineering and by courtesy of Radiology (Precision Health and Integrated Diagnostics)

Stanford University, USA

Sindy KY Tang is the Kenneth and Barbara Oshman Faculty Scholar and Associate Professor of Mechanical Engineering and by courtesy of Radiology (Precision Health and Integrated Diagnostics) at Stanford University. She received her Ph.D. from Harvard University in Engineering Sciences under the supervision of Prof. George Whitesides. Her lab at Stanford works on the fundamental understanding of fluid mechanics and mass transport in micro-nano systems, and the application of this knowledge towards problems in biology, rapid diagnostics for health and environmental sustainability. The current areas of focus include the flow physics of confined micro-droplets using experimental and machine learning methods, interfacial mass transport and self-assembly, and ultrahigh throughput opto-microfluidic systems for disease diagnostics, water and energy sustainability, and single-cell wound healing studies. She was a Stanford Biodesign Faculty Fellow in 2018. Dr. Tang’s work has been recognized by multiple awards including the NSF CAREER Award, 3M Nontenured Faculty Award, the ACS Petroleum Fund New Investigator Award, and invited lecture at the Nobel Symposium on Microfluidics in Sweden.

Sindy has been a committed member of the Lab on a Chip 2022 Commissioning Panel

Find out more on the Tang Lab website and follow @TangSindy on Twitter

Here are a selection of Sindy’s Lab on a Chip papers below:


Yi-Chin Toh

Associate Professor, School of Mechanical, Medical and Process Engineering,  

Queensland University of Technology, Australia

Yi-Chin Toh is a Future Fellow and Associate Professor at the Queensland University of Technology. She obtained her B.Eng in Chemical Engineering and Ph.D in Bioengineering from the National University of Singapore in 2001 and 2008 respectively. She did her post-doctoral training at the Massachusetts Institute of Technology in 2008 under Professor Joel Voldman’s guidance. Before joining QUT, she led an independent research group as an Assistant Professor at the Department of Biomedical Engineering, National University of Singapore.

Her research interest is in engineering multi-scale tissue models to mimic complex biological interactions during human development and diseases, as well as translating them into scalable platforms for disease modeling and drug testing applications. Dr Toh is a recipient of the Australia Research Council Future Fellowship, National University of Singapore Research Scholarship, A*STAR Graduate Scholarship and A*STAR International Fellowship.

Yi-Chin has been a committed member of the Lab on a Chip 2022 Commissioning Panel

Find out more on the MicroTE Lab website and follow @MicroTElab on Twitter

Here are a selection of Yi-Chin’s Lab on a Chip papers below:


Please join us in welcoming our new Advisory Board members and we look forward to continuing to work with them on Lab on a Chip!

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EMBL Conference: Microfluidics 2022

Lab on a Chip is delighted to be sponsoring the EMBL Microfluidics Conference (11-13 July), bringing together top researchers and emerging research leaders to spark scientific exchange and create community. Topics spanning from fundamental physics & chemistry to device design and nascent biological applications will be presented, which should be of interest to everyone from experts in microfluidic design to users of the next-generation of microfluidic tools, and from academic scholars and trainees to industry colleagues.

Session Topics

  • Probing biology
  • Next-generation device design and emerging applications
  • Disease diagnostics, analytical chemistry and chemical synthesis
  • Single-cell and single-molecule analyses

Featured amongst the speaker list is Associate Editor Yoon-Kyoung Cho, & Commissioning Panel member Yi-Chin Toh!


Find out more about the conference:

Date: 11 – 13 Jul 2022

Location: EMBL Heidelberg and Virtual

Deadline(s):

Abstract submission: 19 Apr 2022

Registration (On-site): 9 May 2022

Registration (Virtual): 4 Jul 2022

 

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Lab on a Chip & MicroTAS 2021: Our prize winners!

The hybrid µTAS 2021 meeting was held from 10-14th October, chaired by Amy Herr & Joel Voldman. We’d like to thank all those who entered the awards this year, and to the judging panels who helped us select the winners. All three prizes received excellent submissions and we’re delighted to announce the winners below.


Lab on a Chip/Dolomite Pioneers of Miniaturization Lectureship

Professor Keisuke Goda (University of Tokyo, Japan), has been awarded the 16th Pioneers of Miniaturization Lectureship, sponsored by Dolomite and Lab on a Chip. The Pioneers of Miniaturization Lectureship rewards early to mid-career scientists who have made extraordinary or outstanding contributions to the understanding or development of miniaturised systems.
Like previous years, Professor Goda will receive a monetary award, certificate and plaque, and gave a stunning talk during the µTAS 2021 conference: “a love story of imaging and microfluidics”.


Art in Science Competition
In collaboration with Greg Cooksey from the National Institute of Standards & Technology (NIST), we were pleased to present the Art in Science award:

“Living Impression Sunrise” by Yang Du (Fudan University, China)

An fluorescent image of tumor pre-metastatic perivascular niche. 3D microvessels networks formed by self-assembly of Human Umbilical Vein Endothelial Cells interacted with tumor organoids in this microfluidic chip. The title of this image is inspired by Claude Monet’s Impression Sunrise.


Widmer Poster Prize
The Widmer Poster Prize was awarded this year to Sohyung Lee (UCLA, USA), for her poster and video presentation on “Scalable fabrication of 3D structured microparticles using induced phase separation”. Sohyung put a huge amount of time and effort into her presentation, and the judges were very impressed.


Congratulations to all the winners at this year’s hybrid µTAS conference. We look forward to seeing you at µTAS 2022 (Hangzhou, China)!

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New thematic collection open for submissions – AI in Microfluidics

Read the growing collection here – rsc.li/AIinMicrofluidics

We are delighted to announce a new thematic collection in Lab on a Chip on AI in Microfluidics, with Professors Keisuke Goda, Hang Lu, Peng Fei & Jochen Guck as Thought Leaders.

 

 

The last decade has seen unprecedented growth in computational power and cloud storage breakthroughs in artificial intelligence (AI). AI-produced outcomes have been proven comparable or even superior to the performance of human experts in drug design, material discovery, and medical diagnosis. In these applications, lab on a chip technology, in particular microfluidics, plays an important role as a platform for both the construction and implementation of AI in a large-scale, high-throughput, automated, multiplexed, and cost-effective manner. The goal of this thematic collection is to highlight new advances in this growing field with an emphasis on the interface between technological advancements and impactful applications.

This on-going collection is collated by Thought Leaders Keisuke Goda, Hang Lu, Peng Fei & Jochen Guck, and the Lab on a Chip Editorial Office. Are you interested in submitting? We welcome submissions of original research articles and reviews, which (after peer review) will be published and added to the online collection. Papers in this collection will receive extensive promotion throughout the submission period and also will be disseminated widely as a ‘flagship’ collection for the journal. If you are interested in submitting to the series, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org

This collection is open for submissions now

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