Author Archive

Conference: Bubble Tech to Bio App – “LAB-ON-A-CHIP”

The 2nd Korea – EU Workshop on Microfluidic Technology for Chemical, Biological and Medical Applications will be held later this year at KIST Europe.

The purpose of this international workshop is to bring together researchers, technologists, entrepreneurs and funding bodies to interact in the multidisciplinary field of “Lab on Chip”, specifically aimed at biological and medical applications. All speakers are by invitation only. Ample opportunity for informal talks will also be provided, as delegates will stay at a centralised venue, and contributed posters can be presented. This workshop will focus on the following leading areas of “Lab on Chip” for bio applications:

http://www.kist-europe.com/Conferences/LOC.html

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Hybrid opto-electric manipulation, droplet based microfluidics and digital PCR on the cover of issue 13!

The striking image on the outside front cover of this issue is courtesy of Aloke Kumar (Oak Ridge National Laboratory).  The Critical Review which it highlights discusses the fundamentals, applications and future of hybrid opto-electric manipulation techniques for microfluidics

Hybrid opto-electric manipulation in microfluidics—opportunities and challenges
Aloke Kumar, Stuart J. Williams, Han-Sheng Chuang, Nicolas G. Green and Steven T. Wereley
Lab Chip, 2011, 11, 2135-2148
DOI: 10.1039/C1LC20208A

The equally eye-catching image on the inside front cover is from Valérie Taly and Andrew D. Griffiths (ISIS, Strasbourg) et al., accompanying work on a droplet-based microfluidics method for digital PCR and a method for multiplexing quantitative digital PCR beyond the conventional limitations of color-encoded probes.

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics
Deniz Pekin, Yousr Skhiri, Jean-Christophe Baret, Delphine Le Corre, Linas Mazutis, Chaouki Ben Salem, Florian Millot, Abdeslam El Harrak, J. Brian Hutchison, Jonathan W. Larson, Darren R. Link, Pierre Laurent-Puig, Andrew D. Griffiths and Valérie Taly
Lab Chip, 2011, 11, 2156-2166
DOI: 10.1039/C1LC20128J

Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR
Qun Zhong, Smiti Bhattacharya, Steven Kotsopoulos, Jeff Olson, Valérie Taly, Andrew D. Griffiths, Darren R. Link and Jonathan W. Larson
Lab Chip, 2011, 11, 2167-2174
DOI: 10.1039/C1LC20126C

View the issue

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HOT: continuous electrowetting, assaying sprouting angiogenesis and 3D patterns in a 2D platform

This Communication from Nathan B. Crane (University of South Florida) et al. describes new method of droplet transport, combining diode-like conduction and electrowetting on dielectric to achieve continuous electrowetting with a single electrode.

Continuous electrowetting via electrochemical diodes
Christopher W. Nelson, Corey M. Lynch and Nathan B. Crane
Lab Chip, 2011, 11, 2149-2152
DOI: 10.1039/C1LC20196D


In their paper Seok Chung (Korea University) et al. have developed a hydrogel incorporating a microfluidic platform which can mimic the 3D tissue microenvironment for the study of endothelial cell sprouting angiogenesis.  They are able to precisely control the gradient of soluble angiogenic factors, VEGF and ANG-1 and obtain a quantitative response to the assay.

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients
Yoojin Shin, Jessie S. Jeon, Sewoon Han, Gi-Seok Jung, Sehyun Shin, Sang-Hoon Lee, Ryo Sudo, Roger D. Kamm and Seok Chung
Lab Chip, 2011, 11, 2175-2181
DOI: 10.1039/C1LC20039A


William C. Messner (Carnegie Mellon University) and colleagues have also been working in 3D to achieve dynamic control of 3D chemical patterns in a single 2D microfluidic platform.  They are able to switch between ‘focused’ and ‘defocused’ 3D flow profiles, and to rapidly tune the patterns through feedback control of the inlet pressures.

Dynamic control of 3D chemical profiles with a single 2D microfluidic platform
YongTae Kim, Sagar D. Joshi, Lance A. Davidson, Philip R. LeDuc and William C. Messner
Lab Chip, 2011, 11, 2182-2188
DOI: 10.1039/C1LC20077A

As with all our HOT papers, these are free to access for 4 weeks

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LOC author selected for Priestley Medal

Robert Langer has been named as the 2012 recipient of the ACS Priestley Medal.  Robert Langer, MIT,  is being recognised for his ‘cutting-edge research that helped create the controlled-release drug industry and the field of tissue engineering’.

Congratulations to Professor Langer on this prestigious award!

You can view his latest LOC paper online here

Stimuli-responsive microwells for formation and retrieval of cell aggregates
Halil Tekin, Michael Anaya, Mark D. Brigham, Claire Nauman, Robert Langer and Ali Khademhosseini
Lab Chip, 2010, 10, 2411-2418
DOI: 10.1039/C004732E

Or his recent mini-review for Chemical Science:

Biocompatibility and drug delivery systems
Daniel S. Kohane and Robert Langer
Chem. Sci., 2010, 1, 441-446
DOI: 10.1039/C0SC00203H

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LOC article on brain cell networks in the press!

The recent LOC article from Henry Zeringue (University of Pittsburgh) and team has been highlighted on ScienceDaily. The article describes the creation of a model of the ring-shaped networks of neurons in the brain, to help understand the mechanisms behind persistent activity – which is involved in memory and motor planning.  

Congratulations to Henry Zeringue and team!

You can read Carl Saxton’s Chemistry World article online here or go straight to the Lab on a Chip paper:

Ring-shaped neuronal networks: a platform to study persistent activity
Ashwin Vishwanathan, Guo-Qiang Bi and Henry C. Zeringue,
Lab Chip, 2011, 11, 1081
DOI: 10.1039/c0lc00450b

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Issue 12 now available online – focussing on Dutch research

View the issue online here

This month’s issue is the next instalment in our series of 10th anniversary issues, this time focussing on the best new research from the Netherlands.  Sabeth Verpoorte introduces the issue in her Editorial, describing the progression from macro- to microfluidics in this small, but scientifically strong country.

The issue features work on floating electrodes from Albert van den Berg, artificial cilia from P. R. Onck and J. Westerweel, capillary Stokes drift from Dirk van den Ende, microbubble generation from José Gordillo, two-phase flow systems from Sabeth Verpoorte and micromolding from Michiel Kreutzer.

The issue also features HOT articles from Ryan Bailey, Masaya Hagiwara and Daniel Chiu:


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HOT: new driving force for high accuracy microrobot to manipulate single cells

Manipulating cells in microfluidic chips is often accomplished with a magnetically driven microtool (MMT), driven by a permanent magnet.  However MMTs driven by permanent magnets suffer from low positioning accuracy and response speed.  Here, Masaya Hagiwara (Nagoya University) and colleagues have devised a new way of driving MMTs – using a piezoelectric ceramic induce ultrasonic vibration and reduce the effective friction.  The result is a 1.1 mm positioning accuracy of the microrobot, which is 100 times higher than operating without vibration.

This HOT article is featured on the cover of Issue 12 and is free to access for 6 weeks:

On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations
Masaya Hagiwara, Tomohiro Kawahara, Yoko Yamanishi, Taisuke Masuda, Lin Feng and Fumihito Arai
Lab Chip, 2011, 11, 2049-2054
DOI: 10.1039/C1LC20164F

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HOT: detecting CRP over six orders of magnitude using silicon photonic microring resonators

In their recent paper Ryan Bailey and colleagues at the University of Illinois at Urbana-Champaign address the challenge of creating a biomarker assay capable of spanning a clinically relevant dynamic range.  The ability to accurately detect protein biomarkers over a wide dynamic range is extremely important to determine the stage a disease is at, as well as monitoring the effects of any treatments.

They have developed a a silicon photonic microring resonator-based platform that can quantify the cardiovascular risk biomarker C-reactive protein over a dynamic range of six orders of magnitude.  The 3 step assay increases the dynamic range beyond that possible for a single-step assay and also reduces false positive results.

Download the article for the details – the article is currently free to access:

Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads
Matthew S. Luchansky, Adam L. Washburn, Melinda S. McClellan and Ryan C. Bailey
Lab Chip, 2011, 11, 2042-2044
DOI: 10.1039/C1LC20231F

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Nanospray for nanodrugs

Over the last decade, the molecular complexity of drugs has increased significantly, leading to poor solubility, which means that the compounds can’t be used in the human body. To determine if new formulations have potential as successful drugs, solubility tests are run at an early stage of development. However, the amount of drug available for these tests is usually very small.

One way to get around this problem is by decreasing the compounds’ particle size. David Weitz from Harvard University, Cambridge, US, and colleagues, have done just that by developing a microfluidic device made from poly(dimethylsiloxane), incorporating two flow-focussing streams and a third for compressed air to form a spray, that can generate particle sizes below 100nm.

To find out more read Rebecca Brodie’s Chemistry World article or download the article itself here:

Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer
Julian Thiele, Maike Windbergs, Adam R. Abate, Martin Trebbin, Ho Cheung Shum, Stephan Förster and David A. Weitz
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20298G

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Animated abstracts for LOC!

Check out the shiny new animated abstracts from our authors!

Got a cool piece of animation for your paper? Why not submit it to us today at http://mc.manuscriptcentral.com/lc

Pneumatically tunable optofluidic 2 × 2 switch for reconfigurable optical circuit
Wuzhou Song and Demetri Psaltis
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20220K
Measuring the local pressure amplitude in microchannel acoustophoresis
Rune Barnkob, Per Augustsson, Thomas Laurell and Henrik Bruus
Lab Chip, 2010, 10, 563-570
DOI: 10.1039/B920376A
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