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A chemical time capsule

24 Sep 2014

Inspired by tree rings, scientists have designed a sensing device that records chemical information over time as spatial patterns.

The transformation of time-varying signals into spatially-varying signals is fundamental for recording temporal information. For trees, growth rings that form throughout their lifetime provide a historical record of their growth conditions. Now, a team led by Sindy Tang at Stanford University, US, have designed a time capsule to record information about the occurrence of chemical events.

To read the fill article please visit Chemistry World.

Time capsule: an autonomous sensor and recorder based on diffusion–reaction
Lukas C. Gerber, Liat Rosenfeld, Yunhan Chen and Sindy K. Y. Tang
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00640B, Communication

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New You Tube Videos

11 Sep 2014

Time Capsule: An autonomous sensor and recorder based on diffusion-reaction


Wide bandwidth power amplifier for frequency-selective insulator-based dielectrophoresis


Microfluidic Mixing of Nonpolar Liquids by Contact Charge Electrophoresis



Controlled stimulation-burst targeted release by smart decentered core-shell microcapsules in gravity and magnetic field


On-demand control of microfluidic flow via capillary-tuned solenoid microvalve suction


Catalytic oxygen production mediated by smart capsules to modulate elastic turbulence under laminar flow regime


Electrowetting on Dielectrics for Manipulating Oil Drops and Gas Bubbles in Aqueous-Shell Compound Drops



ElectroTaxis-on-a-Chip (ETC): an Integrated Quantitative High-throughput Screening Platform for Electrical Field-Directed Cell Migration


A reliable, programmable acoustofluidic pump powered by oscillating sharp-edge structures



DLD Pillar Shape Design for Efficient Separation of Spherical and Non-spherical Bioparticles

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New YouTube Videos

27 Aug 2014

Single-Neuron Axonal Pathfinding under Geometric Guidance: Low-Dose-Methylmercury Developmental Neurotoxicity Test

Finger-Powered Microfluidic Systems Using Multilayer Soft Lithography and Injection Molding Processes

Integrated Immunoisolation and Protein Analysis of Circulating Exosomes Using Microfluidic Technology

A microfluidic approach for investigating multicomponent systems thermodynamics at high pressures and temperatures

On the flow topology inside droplets moving in rectangular microchannels

A Microfluidic Linear Node Array for the Study of Protein-Ligand Interaction

Cavity-Induced Microstreaming for Simultaneous On-Chip Pumping and Size-Based Separation of Cells and Particles

Three-dimensional Flash Flow Microreactor for Scale-up Production of Monodisperse PEG-PLGA Nanoparticles

Visualizing oil displacement with foam in a microfluidic device with permeability contrasts

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Free access to HOT articles

24 Jul 2014

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Hepatic organoids for microfluidic drug screening
Sam H. Au, M. Dean Chamberlain, Shruthi Mahesh, Michael V. Sefton and Aaron R. Wheeler
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00531G, Paper

Graphical abstract: Hepatic organoids for microfluidic drug screening
Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels
Raphaël Trouillon and Martin A. M. Gijs
Lab Chip, 2014,14, 2929-2940
DOI: 10.1039/C4LC00493K, Paper

Graphical abstract: Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels

A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies
Samin Akbari and Tohid Pirbodaghi
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00082J, Communication

Graphical abstract: A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies
A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood
Ana I. Barbosa, Ana P. Castanheira, Alexander D. Edwards and Nuno M. Reis
Lab Chip, 2014,14, 2918-2928
DOI: 10.1039/C4LC00464G, Paper
Graphical abstract: A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood

Induced charge electroosmosis micropumps using arrays of Janus micropillars
Joel S. Paustian, Andrew J. Pascall, Neil M. Wilson and Todd M. Squires
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00141A, Paper

Graphical abstract: Induced charge electroosmosis micropumps using arrays of Janus micropillars
Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device
Dirk Steuerwald, Susanna M. Früh, Rudolf Griss, Robert D. Lovchik and Viola Vogel
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00385C, Paper

Graphical abstract: Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device
Femtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass
Koji Sugioka, Jian Xu, Dong Wu, Yasutaka Hanada, Zhongke Wang, Ya Cheng and Katsumi Midorikawa
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00548A, Critical Review

Graphical abstract: Femtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass
Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor
F. Abeille, F. Mittler, P. Obeid, M. Huet, F. Kermarrec, M. E. Dolega, F. Navarro, P. Pouteau, B. Icard, X. Gidrol, V. Agache and N. Picollet-D’hahan
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00570H, Paper

Graphical abstract: Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor
Multiplexed immunoassay based on micromotors and microscale tags
D. Vilela, J. Orozco, G. Cheng, S. Sattayasamitsathit, M. Galarnyk, C. Kan, J. Wang and A. Escarpa
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00596A, Paper

Graphical abstract: Multiplexed immunoassay based on micromotors and microscale tags
Double emulsions from a capillary array injection microfluidic device
Luoran Shang, Yao Cheng, Jie Wang, Haibo Ding, Fei Rong, Yuanjin Zhao and Zhongze Gu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00698D, Communication

Graphical abstract: Double emulsions from a capillary array injection microfluidic device
SU-8 as a material for lab-on-a-chip-based mass spectrometry
Steve Arscott
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00617H, Tutorial Review

Graphical abstract: SU-8 as a material for lab-on-a-chip-based mass spectrometry
Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter
Lothar Schmid, David A. Weitz and Thomas Franke
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00588K, Paper

Graphical abstract: Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter
Physics and technological aspects of nanofluidics
Lyderic Bocquet and Patrick Tabeling
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00325J, Frontier

Graphical abstract: Physics and technological aspects of nanofluidics

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New YouTube videos

18 Jul 2014

Circle-to-circle amplification on a digital microfluidic chip for amplified single molecule detection



Rapid isolation and diagnosis of live bacteria from human joint fluids by using an integrated microfluidic system



Microfluidic on-demand droplet merging using surface acoustic waves


Induced charge electroosmosis micropumps using arrays of Janus micropillars


Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device


Marangoni Self-Propelled Capsules in a Maze: Pollutants ‘Sense and Act’ in Complex Channel Environments


Digital Biology and Chemistry


Split and flow: reconfigurable capillary connection for digital microfluidic


Single-step microfluidic fabrication of soft monodisperse polyelectrolyte microcapsules by interfacial complexation


A Novel Picoliter Droplet Array for Parallel Real-time Polymerase Chain Reaction Based on Double-inkjet Printing

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Organ–organ interactions could compound nanoparticle damage

04 Jul 2014

A microfluidic device that recreates interactions between the gastrointestinal (GI) tract and the liver to give a more realistic assessment of nanoparticle toxicity has detected liver tissue injury at lower nanoparticle concentrations than expected following experiments with liver tissue only.

Many studies look at the beneficial medical effects of nanoparticles, however, Mandy Esch explains that her work in Michael Shuler’s lab at Cornell University is checking for adverse effects.

To read the full article, please visit Chemistry World.

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol and Michael L. Shuler
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00371C, Paper

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New YouTube videos

26 Jun 2014

Dynamics of counterion-induced attraction between vimentin filaments followed in microfluidic drops

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial templates

AC Electric Field Induced Dipole-Based On-Chip 3D Cell Rotation

Testing Aß toxicity on primary CNS cultures using drug-screening microfluidic chips

A smartphone-based chip-scale microscope using ambient illumination

Biofunctionalized self-propelled micromotors as an alternative on-chip concentrating system

Simultaneous thermal and optical imaging of two-phase flow in a micro-model

A Label-Free Microfluidic Assay to quantitatively study antibiotic diffusion through lipid membranes

Deformability-based microfluidic cell pairing and fusion

Rapid, low-cost and instrument-free CD4+ cell counting for HIV diagnostics in resource-poor settings

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Free access to HOT articles

20 Jun 2014

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Donut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels
N. Zurgil, O. Ravid-Hermesh, Y. Shafran, S. Howitz, E. Afrimzon, M. Sobolev, J. He, E. Shinar, R. Goldman-Levi and M. Deutsch
Lab Chip, 2014,14, 2226-2239
DOI: 10.1039/C3LC51426A

Graphical abstract: Donut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels

Dual-pore glass chips for cell-attached single-channel recordings
Brandon R. Bruhn, Haiyan Liu, Stefan Schuhladen, Alan J. Hunt, Aghapi Mordovanakis and Michael Mayer
Lab Chip, 2014,14, 2410-2417
DOI: 10.1039/C4LC00370E

Graphical abstract: Dual-pore glass chips for cell-attached single-channel recordings

In situ fabrication of a temperature- and ethanol-responsive smart membrane in a microchip
Yi-Meng Sun, Wei Wang, Yun-Yan Wei, Nan-Nan Deng, Zhuang Liu, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu
Lab Chip, 2014,14, 2418-2427
DOI: 10.1039/C4LC00273C

Graphical abstract: In situ fabrication of a temperature- and ethanol-responsive smart membrane in a microchip

Multiphase optofluidics on an electro-microfluidic platform powered by electrowetting and dielectrophoresis
Shih-Kang Fan and Fu-Min Wang
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00317A

Graphical abstract: Multiphase optofluidics on an electro-microfluidic platform powered by electrowetting and dielectrophoresis

Deformability-based microfluidic cell pairing and fusion
Burak Dura, Yaoping Liu and Joel Voldman
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00303A

Graphical abstract: Deformability-based microfluidic cell pairing and fusion

Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal
Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor and Euisik Yoon
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00391H

Graphical abstract: Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal

Inertial microfluidic physics
Hamed Amini, Wonhee Lee and Dino Di Carlo
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00128A

Graphical abstract: Inertial microfluidic physics

Nanocrystal synthesis in microfluidic reactors: where next?
Thomas W. Phillips, Ioannis G. Lignos, Richard M. Maceiczyk, Andrew J. deMello and John C. deMello
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00429A

Graphical abstract: Nanocrystal synthesis in microfluidic reactors: where next?
Diffusion-based microfluidic PCR for “one-pot” analysis of cells
Sai Ma, Despina Nelie Loufakis, Zhenning Cao, Yiwen Chang, Luke E. K. Achenie and Chang Lu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00498A

Graphical abstract: Diffusion-based microfluidic PCR for “one-pot” analysis of cells
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Free access to HOT Articles

29 May 2014

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Fluoropolymer surface coatings to control droplets in microfluidic devices
Carson T. Riche, Chuchu Zhang, Malancha Gupta and Noah Malmstadt
Lab Chip, 2014,14, 1834-1841
DOI: 10.1039/C4LC00087K
Graphical abstract: Fluoropolymer surface coatings to control droplets in microfluidic devices
Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties
Song Chen, Huijie Zhang, Xuetao Shi, Hongkai Wu and Nobutaka Hanagata
Lab Chip, 2014,14, 1842-1849
DOI: 10.1039/C4LC00015C

Graphical abstract: Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties
Magnetically controllable 3D microtissues based on magnetic microcryogels
Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00081A

Graphical abstract: Magnetically controllable 3D microtissues based on magnetic microcryogels

Straightforward 3D hydrodynamic focusing in femtosecond laser fabricated microfluidic channels
Petra Paiè, Francesca Bragheri, Rebeca Martinez Vazquez and Roberto Osellame
Lab Chip, 2014,14, 1826-1833
DOI: 10.1039/C4LC00133H

Graphical abstract: Straightforward 3D hydrodynamic focusing in femtosecond laser fabricated microfluidic channels

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations
Meltem Elitas, Rodrigo Martinez-Duarte, Neeraj Dhar, John D. McKinney and Philippe Renaud
Lab Chip, 2014,14, 1850-1857
DOI: 10.1039/C4LC00109E

Graphical abstract: Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Simple, low cost MHz-order acoustomicrofluidics using aluminium foil electrodes
Amgad R. Rezk, James R. Friend and Leslie Y. Yeo
Lab Chip, 2014,14, 1802-1805
DOI: 10.1039/C4LC00182F

Graphical abstract: Simple, low cost MHz-order acoustomicrofluidics using aluminium foil electrodes

Elevating sampling Joseph M. Labuz and Shuichi Takayama
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00125G

Graphical abstract: Elevating sampling

Microfluidic investigation of the deposition of asphaltenes in porous media
Chuntian Hu, James E. Morris and Ryan L. Hartman
Lab Chip, 2014,14, 2014-2022
DOI: 10.1039/C4LC00192C

Graphical abstract: Microfluidic investigation of the deposition of asphaltenes in porous media

Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles
D. J. Paterson, J. Reboud, R. Wilson, M. Tassieri and J. M. Cooper
Lab Chip, 2014,14, 1806-1810
DOI: 10.1039/C4LC00199K

Graphical abstract: Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles
Microfluidics for single-cell genetic analysis
A. M. Thompson, A. L. Paguirigan, J. E. Kreutz, J. P. Radich and D. T. Chiu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00175C

Graphical abstract: Microfluidics for single-cell genetic analysis

A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control
Shuo Lin, Wei Wang, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00039K

Graphical abstract: A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control

Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane
Hongyun So, Albert P. Pisano and Young Ho Seo
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51298C

Graphical abstract: Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane

Microfluidic chip for plasma separation from undiluted human whole blood samples using low voltage contactless dielectrophoresis and capillary force
Chia-Chern Chen, Po-Hsiu Lin and Chen-Kuei Chung
Lab Chip, 2014,14, 1996-2001
DOI: 10.1039/C4LC00196F

Graphical abstract: Microfluidic chip for plasma separation from undiluted human whole blood samples using low voltage contactless dielectrophoresis and capillary force

Influenza A virus-specific aptamers screened by using an integrated microfluidic system
Hsien-Chih Lai, Chih-Hung Wang, Tong-Miin Liou and Gwo-Bin Lee
Lab Chip, 2014,14, 2002-2013
DOI: 10.1039/C4LC00187G

Graphical abstract: Influenza A virus-specific aptamers screened by using an integrated microfluidic system

Energy: the microfluidic frontier
David Sinton
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00267A

Graphical abstract: Energy: the microfluidic frontier

Patent protection and licensing in microfluidics
Ali K. Yetisen and Lisa R. Volpatti
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00399C

Graphical abstract: Patent protection and licensing in microfluidics

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A chemical time capsule

New You Tube Videos

Top ten most accessed LOC articles in Q2 2014

New YouTube Videos

Free access to HOT articles

New YouTube videos

Organ–organ interactions could compound nanoparticle damage

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Free access to HOT Articles

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