Author Archive

Top ten most accessed LOC articles in Q1 2014

This month sees the following articles in Lab on a Chip that are in the top ten most accessed January – March:-

Continuous focusing of microparticles using inertial lift force and vorticity via multi-orifice microfluidic channels 
Jae-Sung Park, Suk-Heung Song and Hyo-Il Jung 
Lab Chip, 2009,9, 939-948 
DOI: 10.1039/B813952K  
  
Paper-based microfluidic point-of-care diagnostic devices 
Ali Kemal Yetisen, Muhammad Safwan Akram and Christopher R. Lowe    
Lab Chip, 2013,13, 2210-2251
DOI: 10.1039/C3LC50169H  
 
Rare cell isolation and analysis in microfluidics 
Yuchao Chen, Peng Li, Po-Hsun Huang, Yuliang Xie, John D. Mai, Lin Wang, Nam-Trung Nguyen and Tony Jun Huang    
Lab Chip, 2014,14, 626-645
DOI: 10.1039/C3LC90136J  
  
Droplet microfluidics 
Shia-Yen Teh, Robert Lin, Lung-Hsin Hung and Abraham P. Lee    
Lab Chip, 2008,8, 198-220
DOI: 10.1039/B715524G  
  
Lab-in-a-pen: a diagnostics format familiar to patients for low-resource settings 
Max M. Gong, Brendan D. MacDonald, Trung Vu Nguyen, Kinh Van Nguyen and David Sinton    
Lab Chip, 2014,14, 957-963
DOI: 10.1039/C3LC51185E  
 
Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry 
Lisen Wang, Lisa A. Flanagan, Noo Li Jeon, Edwin Monuki and Abraham P. Lee    
Lab Chip, 2007,7, 1114-1120
DOI: 10.1039/B705386J  
 
Particle separation using virtual deterministic lateral displacement (vDLD) 
David J. Collins, Tuncay Alan and Adrian Neild    
Lab Chip, 2014,14, 1595-1603
DOI: 10.1039/C3LC51367J  
 
Light-assisted direct-write of 3D functional biomaterials 
Kolin C. Hribar, Pranav Soman, John Warner, Peter Chung and Shaochen Chen    
Lab Chip, 2014,14, 268-275 
DOI: 10.1039/C3LC50634G 
 
Wettability patterning for high-rate, pumpless fluid transport on open, non-planar microfluidic platforms 
Aritra Ghosh, Ranjan Ganguly, Thomas M. Schutzius and Constantine M. Megaridis    
Lab Chip, 2014,14, 1538-1550
DOI: 10.1039/C3LC51406D 
 
Automated analysis of dynamic behavior of single cells in picoliter droplets 
Mohammad Ali Khorshidi, Prem Kumar Periyannan Rajeswari, Carolina Wählby, Haakan N. Joensson and Helene Andersson Svahn    
Lab Chip, 2014,14, 931-937
DOI: 10.1039/C3LC51136G  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions

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Imaging adherent cell in microfluidic channel hidden by flowing RBCs as occluding objects by holographic method 

 
 
  
Microdevice arrays of high aspect ratio Poly(DiMethylSiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties 

 
   
Event-Triggered Logical Flow Control for Comprehensive Process Integration of Multi-Step Assays on Centrifugal Microfluidic Platforms 

 
 
  
Phaseguide assisted liquid lamination for magnetic particle-based assays 

 
   
Preparation of Monodisperse Microbubbles using an Integrated Embedded Capillary T-Junction with Electrohydrodynamic Focusing 

 
 
  
Hydrogel Bioprinted Microchannel Networks for Vascularization of Tissue Engineering Constructs 

 
 
   
A high-efficiency microfluidic device for size-selective trapping and sorting 

 
 
  
In-fiber integrated optofluidic device based on optical fiber with an inner core 

 
 
  
Automated single cell microbioreactor for monitoring intracellular dynamics and cell growth in free solution 

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Gregory A. Cooksey and Javier Atencia  
Lab Chip, 2014,14, 1665-1668
DOI: 10.1039/C4LC00173G, Technical Innovation

Graphical abstract: Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Timothy Kwa, Qing Zhou, Yandong Gao, Ali Rahimian, Lydia Kwon, Ying Liu and Alexander Revzin  
Lab Chip, 2014,14, 1695-1704
DOI: 10.1039/C4LC00037D, Paper

Graphical abstract: Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
David Erickson, Dakota O’Dell, Li Jiang, Vlad Oncescu, Abdurrahman Gumus, Seoho Lee, Matthew Mancuso and Saurabh Mehta  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00142G, Frontier

Graphical abstract: Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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The Microfluidic Puzzle: Chip-oriented Rapid Prototyping 
 
  
 
Fluoropolymer surface coatings to control droplets in microfluidic devices 
 
 
  
Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles 
   

Caterpillar Locomotion–inspired Valveless Pneumatic Micropump using Single Teardrop-shaped Elastomeric Membrane 
 
   
  
In-fiber integrated optofluidic device based on optical fiber with an inner core 
 
 
  
Solvent Immersion Imprint Lithography 
 
 
    
Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations 
 
   
 
Shaken and Stirred: Oscillatory Segmented Flow for Controlled Size-Evolution of Colloidal Nanomaterials 
 
 
  
Particles Optical Trapping and Binding in Optofluidic Stable Fabry–Pérot Resonator with Single-Sided Injection 

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections
Liesbet Van Heirstraeten, Peter Spang, Carmen Schwind, Klaus S. Drese, Marion Ritzi-Lehnert, Benjamin Nieto, Marta Camps, Bryan Landgraf, Francesc Guasch, Antoni Homs Corbera, Josep Samitier, Herman Goossens, Surbhi Malhotra-Kumar and Tina Roeser  
Lab Chip, 2014,14, 1519-1526
DOI: 10.1039/C3LC51339D, Paper

Graphical abstract: Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections

Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing
J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00050A, Paper

Graphical abstract: Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing

Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips
Laura Restrepo-Pérez, Lluís Soler, Cynthia S. Martínez-Cisneros, Samuel Sánchez and Oliver G. Schmidt  
Lab Chip, 2014,14, 1515-1518
DOI: 10.1039/C3LC51419F, Communication

Graphical abstract: Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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DVD diagnostics

A pregnancy test based on standard DVD technology has the potential to be turned into a diagnostic platform that screens for abnormal pregnancies or even testicular cancer.

The DVD assay design and signal reading principle

We all hate waiting for tests results, especially when it comes to medical tests where the uncertainty of not knowing what’s wrong can be a real worry. As a result, the development of diagnostic tests that can be performed wherever the patient is, whether that is at home, in a doctor’s surgery or in a medical centre in the developing world, obtaining almost instantaneous results is a current hot topic. Over the past few years, a wide range of point-of-care diagnostic platforms have been developed and the field holds tremendous potential, perhaps one day eliminating the need for laboratory-based diagnostic tests altogether.

To read the full article please visit Chemistry World.

DVD technology-based molecular diagnosis platform: quantitative pregnancy test on a disc
Xiaochun Li, Samuel Weng, Bixia Ge, Zhihui Yao and Hua-Zhong Yu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51411K, Paper

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A high-throughput device for size based separation of C. elegans developmental stages 


 
  
 Packaging Commercial CMOS Chips for Lab on a Chip Integration 


 
  
 
Microfluidic chip for plasma separation from undiluted human whole blood sample using low voltage contactless dielectrophoresis and capillary force 

 
   
 
Novel side electrode configuration integrated in fused silica microsystems for synchronous optical and electrical spectroscopy 

 
 
  
 Clog-free Cell Filtration Using Resettable Cell Traps 

 
 
  
 High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics 

 
   
 Acoustic Actuated Fluorescence Activated Sorting of Microparticles 

 
   
 
Photo-thermal Effect for Localized Desorption of Primary Lymphocytes Arrayed on an Antibody/DNA-based Biochip 

 
 
  
 A biocompatible open-surface droplet manipulation platform for detection of multi-nucleotide polymorphism 


 
 
 Wettability patterning for high-rate, pumpless fluid transport on open, non-planar, microfluidic platforms 

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Gas-liquid-liquid three-phase flow pattern and pressure drop in a microfluidic chip: similarities with gas-liquid/liquid-liquid flows 


 
 
Dual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors 


 
  
Extracellular-controlled Breast Cancer Cell Formation and Growth Using Non-UV Patterned Hydrogels via Optically-induced Electrokinetics 


 
 
A Microfluidic Tubing Method and Its Application to Controlled Synthesis of Polymeric Nanoparticles 


 
 
Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns 


 
 
“Particle separation using virtual deterministic lateral displacement
(vDLD)”
 


 
 
Microfluidic Bead-Based Diodes with Targeted Circular Microchannels for Low Reynolds Number Applications 


 
 
In vitro generation of colonic epithelium from primary cells guided by microstructures 


 
 
Magnetically Controllable 3D Microtissues based on Magnetic microcryogels 


 
 
A droplet-based pH regulator in microfluidics 

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers
Wonju Jo, Dayeong Jeong, Junho Kim, Siwoo Cho, Su Chul Jang, Chungmin Han, Ji Yoon Kang, Yong Song Gho and Jaesung Park  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC50993A, Paper

Graphical abstract: Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers
A microfluidic photobioreactor array demonstrating high-throughput screening for microalgal oil production
Hyun Soo Kim, Taylor L. Weiss, Hem R. Thapa, Timothy P. Devarenne and Arum Han  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51396C, Paper

Graphical abstract: A microfluidic photobioreactor array demonstrating high-throughput screening for microalgal oil production
Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices
Anthony K. Au, Wonjae Lee and Albert Folch  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51360B, Paper

Graphical abstract: Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices
Recent advancements in optofluidics-based single-cell analysis: optical on-chip cellular manipulation, treatment, and property detection
Nien-Tsu Huang, Hua-li Zhang, Meng-Ting Chung, Jung Hwan Seo and Katsuo Kurabayashi  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51211H, Critical Review

Graphical abstract: Recent advancements in optofluidics-based single-cell analysis: optical on-chip cellular manipulation, treatment, and property detection
Electrokinetically driven reversible banding of colloidal particles near the wall
Necmettin Cevheri and Minami Yoda  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51341F, Communication

Graphical abstract: Electrokinetically driven reversible banding of colloidal particles near the wall
Micro-patterning of mammalian cells on suspended MEMS resonant sensors for long-term growth measurements
Elise A. Corbin, Brian R. Dorvel, Larry J. Millet, William P. King and Rashid Bashir  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51217G, Technical Innovation

Graphical abstract: Micro-patterning of mammalian cells on suspended MEMS resonant sensors for long-term growth measurements
*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Tiny islands set sperm spinning

A platform for simultaneously screening thousands of sperm cells could lead to more efficient identification of high performing sperm for fertility treatments.

Protein islands trap individual sperm cells for motility analysis

 Assisted reproductive technologies have revolutionised the fertility world, however, sperm must be carefully picked on the basis of specific characteristics, including motility, to increase the chance of a successful pregnancy. However, more than half of the sperm selected for intra-cytoplasmic sperm injection (ICSI) using current procedures are damaged.

To read the full article, please go to Chemistry World.

Make it Spin: Individual Trapping of Sperm for Analysis and Recovery Using Micro-Contact Printing
Jean-Philippe Frimat, Mathijs Bronkhorst, Bjorn de Wagenaar, Johan Bomer, Ferdi van der Heijden, Albert van den Berg and Loes Segerink  
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00050A, Paper

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