Lab on a Chip is delighted to announce a 2010 Impact Factor of 6.26, demonstrating the community support for Lab on a Chip as their journal of choice for miniaturisation at the micro and nanoscale, for both fundamental and applications-based research.
Our thanks to all of our Editorial and Advisory Board members, authors and referees.
View the RSC Publishing blog for important news on the overall RSC Impact Factor performance.
Another LOC article has been highlighted in Chemistry World! This article from Mu Chiao and colleagues describes the fabrication of a device that could be implanted behind the eye to release drugs on demand to treat retinal damage caused by diabetes.
Diabetic retinopathy can lead to blindness. A current treatment is laser therapy, which is destructive and results in side effects, such as diminished side and night vision, and unwanted laser burns. Another therapy is to administer antiproliferative drugs, such as docetaxel (normally a cancer drug), but the compounds clear from the blood quickly, so high doses are needed to produce the desired effect, which increases toxicity to other tissues.
Mu Chiao and colleagues from the University of British Columbia in Vancouver have made a device to be implanted behind the eye that releases drugs when triggered by an external magnet. This means that the device doesn’t need a battery and lower doses can be used. Implantable devices have been made before but drug release is done by diffusion and the release rates can’t be controlled, which is a problem if the dosage rate needs to be adjusted when a patient’s condition changes.
To find out more read Elinor Richard’s Chemistry World article or download the article itself here:
On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device
Fatemeh Nazly Pirmoradi, John K. Jackson, Helen M. Burt and Mu Chiao
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20134D
The two striking images on the cover of Issue 14 are from Chan Beum Park and Tony Jun Huang.
Artificial photosynthesis on a chip: microfluidic cofactor regeneration and photoenzymatic synthesis under visible light
Joon Seok Lee, Sahng Ha Lee, Jae Hong Kim and Chan Beum Park
Lab Chip, 2011, 11, 2309-2311
DOI: 10.1039/C1LC20303G
Three-dimensional continuous particle focusing in a microfluidic channel via standing surface acoustic waves (SSAW)
Jinjie Shi, Shahrzad Yazdi, Sz-Chin Steven Lin, Xiaoyun Ding, I-Kao Chiang, Kendra Sharp and Tony Jun Huang
Lab Chip, 2011, 11, 2319-2324
DOI: 10.1039/C1LC20042A
This month sees the following articles in Lab on a Chip that are in the top ten most accessed:-
Quantitative and sensitive detection of rare mutations using droplet-based microfluidics
Deniz Pekin, Yousr Skhiri, Jean-Christophe Baret, Delphine Le Corre, Linas Mazutis, Chaouki Ben Salem, Florian Millot, Abdeslam El Harrak, J. Brian Hutchison, Jonathan W. Larson, Darren R. Link, Pierre Laurent-Puig, Andrew D. Griffiths and Valérie Taly
Lab Chip, 2011, 11, 2156-2166
DOI: 10.1039/C1LC20128J
Paper-based piezoresistive MEMS sensors
Xinyu Liu, Martin Mwangi, XiuJun Li, Michael O’Brien and George M. Whitesides
Lab Chip, 2011, 11, 2189-2196
DOI: 10.1039/C1LC20161A
Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR
Qun Zhong, Smiti Bhattacharya, Steven Kotsopoulos, Jeff Olson, Valérie Taly, Andrew D. Griffiths, Darren R. Link and Jonathan W. Larson
Lab Chip, 2011, 11, 2167-2174
DOI: 10.1039/C1LC20126C
Micromolding of solvent resistant microfluidic devices
Theodorus J. A. Renckens, Dainius Janeliunas, Hilbert van Vliet, Jan H. van Esch, Guido Mul and Michiel T. Kreutzer
Lab Chip, 2011, 11, 2035-2038
DOI: 10.1039/C0LC00550A
Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation
Ali Asgar S. Bhagat, Han Wei Hou, Leon D. Li, Chwee Teck Lim and Jongyoon Han
Lab Chip, 2011, 11, 1870-1878
DOI: 10.1039/C0LC00633E
Systematic investigation of droplet generation at T-junctions
Thomas Schneider, Daniel R. Burnham, Jaylen VanOrden and Daniel T. Chiu
Lab Chip, 2011, 11, 2055-2059
DOI: 10.1039/C1LC20259F
Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)
Ivan K. Dimov, Lourdes Basabe-Desmonts, Jose L. Garcia-Cordero, Benjamin M. Ross, Antonio J. Ricco and Luke P. Lee
Lab Chip, 2011, 11, 845-850
DOI: 10.1039/C0LC00403K
Mixing enhancement for high viscous fluids in a microfluidic chamber
Shasha Wang, Xiaoyang Huang and Chun Yang
Lab Chip, 2011, 11, 2081-2087
DOI: 10.1039/C0LC00695E
Miniature magnetic resonance system for point-of-care diagnostics
David Issadore, Changwook Min, Monty Liong, Jaehoon Chung, Ralph Weissleder and Hakho Lee
Lab Chip, 2011, 11, 2282-2287
DOI: 10.1039/C1LC20177H
On-chip background noise reduction for cell-based assays in droplets
Pascaline Mary, Angela Chen, Irwin Chen, Adam R. Abate and David A. Weitz
Lab Chip, 2011, 11, 2066-2070
DOI: 10.1039/C1LC20159J
Why not take a look at the articles today and blog your thoughts and comments below.
Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.
A new method to fabricate microwells for lab-on-a-chip scale high-throughput screening is demonstrated in this HOT article. Whereas previous manufacturing processes can be long, costly and require a lot of equipment, this technique is relatively simple and cheap.
By using a laser to pattern a polyester film coated with silicone glue, Ali Khademhosseini, Harvard-MIT, and colleagues have successfully demonstrated the fabrication of hundreds of microwells in a matter of minutes. The diameter of the microwells can be controlled by adjusting laser speed and power, and the well depth can be increased by stacking layers of film.
Download the article to read more – it’s free to access for the next 4 weeks:
Microfabricated polyester conical microwells for cell culture applications
Šeila Selimović, Francesco Piraino, Hojae Bae, Marco Rasponi, Alberto Redaelli and Ali Khademhosseini
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20213H
The 2nd Korea – EU Workshop on Microfluidic Technology for Chemical, Biological and Medical Applications will be held later this year at KIST Europe.
The purpose of this international workshop is to bring together researchers, technologists, entrepreneurs and funding bodies to interact in the multidisciplinary field of “Lab on Chip”, specifically aimed at biological and medical applications. All speakers are by invitation only. Ample opportunity for informal talks will also be provided, as delegates will stay at a centralised venue, and contributed posters can be presented. This workshop will focus on the following leading areas of “Lab on Chip” for bio applications:
http://www.kist-europe.com/Conferences/LOC.html
Hybrid opto-electric manipulation in microfluidics—opportunities and challenges
Aloke Kumar, Stuart J. Williams, Han-Sheng Chuang, Nicolas G. Green and Steven T. Wereley
Lab Chip, 2011, 11, 2135-2148
DOI: 10.1039/C1LC20208A
The equally eye-catching image on the inside front cover is from Valérie Taly and Andrew D. Griffiths (ISIS, Strasbourg) et al., accompanying work on a droplet-based microfluidics method for digital PCR and a method for multiplexing quantitative digital PCR beyond the conventional limitations of color-encoded probes.
Deniz Pekin, Yousr Skhiri, Jean-Christophe Baret, Delphine Le Corre, Linas Mazutis, Chaouki Ben Salem, Florian Millot, Abdeslam El Harrak, J. Brian Hutchison, Jonathan W. Larson, Darren R. Link, Pierre Laurent-Puig, Andrew D. Griffiths and Valérie Taly
Lab Chip, 2011, 11, 2156-2166
DOI: 10.1039/C1LC20128J
Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR
Qun Zhong, Smiti Bhattacharya, Steven Kotsopoulos, Jeff Olson, Valérie Taly, Andrew D. Griffiths, Darren R. Link and Jonathan W. Larson
Lab Chip, 2011, 11, 2167-2174
DOI: 10.1039/C1LC20126C
Continuous electrowetting via electrochemical diodes
Christopher W. Nelson, Corey M. Lynch and Nathan B. Crane
Lab Chip, 2011, 11, 2149-2152
DOI: 10.1039/C1LC20196D
In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients
Yoojin Shin, Jessie S. Jeon, Sewoon Han, Gi-Seok Jung, Sehyun Shin, Sang-Hoon Lee, Ryo Sudo, Roger D. Kamm and Seok Chung
Lab Chip, 2011, 11, 2175-2181
DOI: 10.1039/C1LC20039A
Dynamic control of 3D chemical profiles with a single 2D microfluidic platform
YongTae Kim, Sagar D. Joshi, Lance A. Davidson, Philip R. LeDuc and William C. Messner
Lab Chip, 2011, 11, 2182-2188
DOI: 10.1039/C1LC20077A
As with all our HOT papers, these are free to access for 4 weeks
Robert Langer has been named as the 2012 recipient of the ACS Priestley Medal. Robert Langer, MIT, is being recognised for his ‘cutting-edge research that helped create the controlled-release drug industry and the field of tissue engineering’.
Congratulations to Professor Langer on this prestigious award!
You can view his latest LOC paper online here
Stimuli-responsive microwells for formation and retrieval of cell aggregates
Halil Tekin, Michael Anaya, Mark D. Brigham, Claire Nauman, Robert Langer and Ali Khademhosseini
Lab Chip, 2010, 10, 2411-2418
DOI: 10.1039/C004732E
Or his recent mini-review for Chemical Science:
Biocompatibility and drug delivery systems
Daniel S. Kohane and Robert Langer
Chem. Sci., 2010, 1, 441-446
DOI: 10.1039/C0SC00203H
The recent LOC article from Henry Zeringue (University of Pittsburgh) and team has been highlighted on ScienceDaily. The article describes the creation of a model of the ring-shaped networks of neurons in the brain, to help understand the mechanisms behind persistent activity – which is involved in memory and motor planning.
Congratulations to Henry Zeringue and team!
You can read Carl Saxton’s Chemistry World article online here or go straight to the Lab on a Chip paper:
Ring-shaped neuronal networks: a platform to study persistent activity
Ashwin Vishwanathan, Guo-Qiang Bi and Henry C. Zeringue,
Lab Chip, 2011, 11, 1081
DOI: 10.1039/c0lc00450b
