HOT: a quick, cheap method for fabricating microwells for cell cultures

A new method to fabricate microwells for lab-on-a-chip scale high-throughput screening is demonstrated in this HOT article.  Whereas previous manufacturing processes can be long, costly and require a lot of equipment, this technique is relatively simple and cheap.

By using a laser to pattern a polyester film coated with silicone glue, Ali Khademhosseini, Harvard-MIT, and colleagues have successfully demonstrated the fabrication of hundreds of microwells in a matter of minutes.  The diameter of the microwells can be controlled by adjusting laser speed and power, and the well depth can be increased by stacking layers of film.

Download the article to read more – it’s free to access for the next 4 weeks:

Microfabricated polyester conical microwells for cell culture applications
Šeila Selimović, Francesco Piraino, Hojae Bae, Marco Rasponi, Alberto Redaelli and Ali Khademhosseini
Lab Chip, 2011, Advance Article
DOI: 10.1039/C1LC20213H

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