In a collaboration between researchers at the University of Oxford, Nankai University and Tsinghua University, Luet-Lok Wong and colleagues determined the substrate-free crystal structure of a variant of CYP102A1 (P450BM3) with generic activity-enhancing properties (KT2).
The electronic properties and the catalytic behaviour of KT2 were investigated and the authors proposed that the rate accelerating properties arise from the substrate-free form being in a catalytically ready conformation, such that substrate-induced changes to the structure play a less significant role in promoting the first electron transfer than in the Wild Type.
This Hot Article will be included in a themed issue of the journal to celebrate 40 years of Dalton Transactions.
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Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450BM3) variant
Christopher J. C. Whitehouse, Wen Yang, Jake A. Yorke, Henry G. Tufton, Lydia C. I. Ogilvie, Stephen G. Bell, Weihong Zhou, Mark Bartlam, Zihe Rao and Luet-Lok Wong
Dalton Trans., 2011, Advance Article
DOI: 10.1039/C1DT10098J, Paper
In this HOT article, Ian Dance examines afresh the relationships between CO and H on nitrogenase cofactors following the recent finding that vanadium nitrogenase and modified molybdenum nitrogenase reduce CO to hydrocarbons. In order to assist the interpretation of kinetic infrared spectral data, vibrational frequencies and modes have been calculated for a variety of possible structures in which FeMo-co bears H atoms, or CO ligands, or both.
In this HOT article, Wu and Yamauchi et al., reported the synthesis of highly ordered mesoporous alumina thin films existing both as P63/mmc and Fm-3m mesostructures by using triblock copolymer Pluronic P123 as a structure-directing agent and their framework crystallization to γ-alumina phase at 1000 °C. During the crystallization process, large uniaxial shrinkage occurred along the direction perpendicular to the substrate with the retention of horizontal mesoscale periodicity, thereby forming vertically oriented nanopillars on the film surface.
This Dalton Transactions Hot article explores metalloligands inspired by the active site of enzymes.
This Dalton Transactions Hot article looks at the self assembly of polyhedral cages.
