Fiona McKenzie, Executive Editor – Page 3

Author Archive

Neurodegeneration: Metallostasis and Proteostasis

12 Sep 2011

Now Published in the RSC Drug Discovery Series

Neurodegeneration: Metallostasis and Proteostasis

Edited by Danilo Milardi and Enrico Rizzarelli

Substantial evidence has accumulated indicating that diverse neurological disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease and small molecules with the potential to control metal homeostasis are expected to provide the framework for the design of novel proteostasis regulators.

This exemplary new book provides an up-to-date perspective on the latest developments in this fast moving field. Traditional views are compared with new emerging ideas in the neuroscience of metal ions. The book will be essential reading for neuroscientists and medicinal chemists working in both industry and academia.

http://www.rsc.org/shop/books/2011/9781849730501.asp

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Membrane Engineering for the Treatment of Gases

12 Sep 2011

Now Published

Membrane Engineering for the Treatment of Gases

Edited By Enrico Drioli and Giuseppe Barbieri

This two-volume set presents the state-of-the-art in membrane engineering for the separation of gases. It addresses future developments in carbon capture and utilization, H2 production and purification and O2/N2 separation. Topics covered include: applications of membrane gas separation in the petrochemical industry, implementation of membrane processes for post-combustion capture, commercial applications of membranes in gas separations, simulation of membrane systems for CO2 capture, design and development of membrane reactors for industrial applications, Pd-based membranes in hydrogen production and purification, novel hybrid membrane/pressure swing adsorption process for gas separation, molecular dynamics as a new tool for membrane design and the physical aging of membranes for gas separations.

Volume One focuses predominantly on gas-separation problems relating to membranes and Volume Two on gas-separation problems combined with membrane reactors. Both volumes will be essential reading for all those involved in chemical, petrochemical , environmental and energy engineering.

http://www.rsc.org/shop/books/2011/9781849732444.asp

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Environmental Cardiology

10 Dec 2010

Now Published in the Issues in Toxicology Series

Environmental Cardiology: Pollution and Heart Disease

Edited by Aruni Bhatnagar, University of Louisville, USA

The first landmark publication to provide a comprehensive multidisciplinary review on the emerging field of environmental cardiology and current research linking pollutant exposure to heart disease. The book begins with an introductory chapter on the environmental basis of cardiovascular disease and the role of the environment in evolution. It provides a new classification for the different categories of the human environment and provides and in-depth analysis of the role of the natural, social and personal environments in modifying and transmitting the risk for heart disease. Subsequent chapters discuss how exposure to particular air pollutants, vehicular exhaust, manufactured nanoparticles and pollutants such as metals, arsenic and environmental aldehydes affect the risk of developing cardiovascular disease. Both experimental and epidemiological evidence are discussed as well as the impact of exposure to air pollution on hypertension, atherogenesis, ischemic heart disease and heart failure.

The book is essential reading for cardiologists, epidemiologists, urban planners and pollution control specialists.

http://www.rsc.org/shop/books/2010/9781849730051.asp

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Stem Cell-Based Tissue Repair

10 Dec 2010

Now Published

Stem Cell-Based Tissue Repair

Edited by Raphael Gorodetsky, Hadassah Hebrew-University, Israel and Richard Schäfer, Harvard University, USA

Regenerative medicine is a relatively new field of medical science with vast potential in different clinical applications. This exemplary new book presents a wide range of approaches on stem cell-based regenerative medicine. The first part introduces the reader to the history and different aspects of basic and applied stem cell research. It presents different sources of progenitor or stem cells whilst comparing their abilities. The difficulties in the practical derivation and application of stem cells from different sources are also discussed. A more comprehensive overview of stem cell-based and matrix association in the attempt to regenerate organs from stem cells engineering is presented in parts two and three. The advantages and problems associated with the interactions of stem cells with different scaffold matrices, the differentiation potential of stem cells and the major difficulties associated with the application of stem cells for clinical practice are discussed. Issues relating to stem cell-based tissue regeneration and the possible immunomodulation and homing of stem cells and the issues relating to the ability to establish good manufacturing practice.

The book will be a valuable reference resource for students and researchers involved in cell biology, tissue engineering and regenerative medicine.

http://www.rsc.org/shop/books/2010/9781849730013.asp

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New Frontiers in Chemical Biology

03 Dec 2010

Now Published in the RSC Drug Discovery Series

New Frontiers in Chemical Biology: Enabling Drug Discovery

Edited by Mark E. Bunnage, Executive Director, Worldwide Medicinal Chemistry, Pfizer Inc., UK

New Frontiers in Chemical Biology: Enabling Drug Discovery highlights a number of key areas of chemical biology that are of direct relevance to the field of drug discovery. The book illustrates the powerful role that chemical genetic and chemical proteomic approaches can play in interrogating biological mechanisms and developing a deeper understanding of how small molecules interact in more complex biological systems. The modulation of stem cell behaviour through small molecules is also discussed and the emerging field of epigenetics is highlighted through a review of the chemical biology of histones. An overview of chemologic approaches includes highlights from the areas of synthetic vaccines and oligonucleotide therapeutics, and additional chapters focus in more depth on Antibody Drug Conjugates and DNA-encoded chemical libraries.

The book will be a valuable resource for scientists both in industry and academia who are looking to raise their awareness of chemical biology and how it may enable future drug discovery.

http://www.rsc.org/shop/books/2010/9781849731256.asp

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Building Integrated Photovoltaic Thermal Systems

02 Nov 2010

Now Published in the RSC Energy Series

Building Integrated Photovoltaic Thermal Systems for Sustainable Developments

Authors: Basant Agrawal and G. N. Tiwari

Solar photovoltaics is one of the most promising renewable energy technologies, producing electricity on site directly from solar radiation. The BIPVT system is a technology which merges PV and thermal systems simultaneously providing both electric and thermal energy. Benefits of the BIPVT system include increased electrical performance, faster payback than traditional systems, negligible impact on the environment and the product is less expensive to install. In this exemplary new book the authors describe recent developments in PV technologies, various BIPVT systems and their applications, energy and exergy analysis, carbon dioxide migration, credit earned, life cycle cost analysis and conversion efficiency. It will be essential reading for students, scientists and engineers involved in energy studies, architecture and building design.

http://www.rsc.org/publishing/ebooks/2010/9781849730907.asp

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In Silico Toxicology

02 Nov 2010

Now Published in the Issues in Toxicology Series

In Silico Toxicology: Principles and Applications

Editors: Mark T. D. Cronin and Judith C. Madden

In Silico methods to predict toxicity are becoming increasingly important, particularly in light of European legislation such as REACH. The objective of this exemplary new book is to enable the reader to develop new and use existing, in silico methods to predict the toxicity and fate of chemicals. The book develops the theme in a logical sequence leading the reader through the retrieval and assessment of quality, of toxicological data and information, the calculation of descriptors and properties, the basis of statistical techniques for QSARs, the interpretation and validation of models for regulatory use, the mechanistic basis to modelling, as well as chemical grouping approaches and application of models for risk assessment. With contributions from recognised leaders and real-world case studies the book will be essential reading for toxicologists and modellers using in silico approaches to perform risk assessment for regulatory purposes.

http://www.rsc.org/shop/books/2010/9781849730044.asp

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Innovations in Fuel Cell Technologies

20 Oct 2010

Now Published in the RSC Energy and Environment Series

Innovations in Fuel Cell Technologies

Editors: Drs. Robert Steinberger-Wilckens and Werner Lehnert, Forschungszentrum Jülich. Germany

The potential in fuel cell technologies is tremendous and their commerical success is necessary in tailoring the worldwide energy supply systems towards efficiencies and emission levels that allow a long-term stable and sustainable development for the world economy and the environment. This exemplary new book provides a state-of-the-art review on new fields of research that have high potential and interest for the fuel cell community. The main technology problems are discussed and current gaps to market success identified. The innovations covered in the book deliver new answers to pertinent problems and/or offer new opportunities, be it in operating conditions, application area, extension of lifetime, new fuels, exciting new diagnosis or analysis methods.

http://www.rsc.org/shop/books/2010/9781849730334.asp

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Accounts in Drug Discovery

05 Oct 2010

Now Published in the RSC Drug Discovery Series

Accounts in Drug Discovery: Case Studies in Medicinal Chemistry

Editors: Drs. Joel C. Barrish, Percy H. Carter, Peter T.W. Cheng and Robert Zahler

An exemplary new volume that covers a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high-throughput screening ‘hits’ to rational structure-based design. The chapters include ‘follow-ons’ and ‘next generation’ compounds. The case studies survey the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology including proof-of-concept in the clinic for novel biological targets. Case studies include recently approved and marketed drugs, but also chronicle ‘near misses’, i.e. exemplary compounds that may have proceeded into the clinic but for various reasons did not result in a successful registration.

http://www.rsc.org/shop/books/2010/9781849731263.asp

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Vibrationally Mediated Photodissociation

03 Sep 2010

Vibrationally Mediated Photodissociation (VMP) deals with the influence of vibrational excitation of the ground electronic state of a molecule on its dissociation following excitation of this state to a higher electronic state. The author, Salman (Zamik) Rosenwaks from Ben-Gurion University of the Negev, Israel, presents the methodology via state-of-the-art examples. The level of presentation is appropriate for senior undergraduate and graduate students of chemistry and physics. It is intended to serve as an introduction to VMP for beginners and as a literature guide to those acquainted with the subject but not necessarily working on VMP.

http://www.rsc.org/shop/books/2009/9780854041558.asp

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Author Archive

Neurodegeneration: Metallostasis and Proteostasis

Membrane Engineering for the Treatment of Gases

Environmental Cardiology

Stem Cell-Based Tissue Repair

New Frontiers in Chemical Biology

Building Integrated Photovoltaic Thermal Systems

In Silico Toxicology

Innovations in Fuel Cell Technologies

Accounts in Drug Discovery

Vibrationally Mediated Photodissociation

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