Now Published in the RSC Drug Discovery Series
Accounts in Drug Discovery: Case Studies in Medicinal Chemistry
Editors: Drs. Joel C. Barrish, Percy H. Carter, Peter T.W. Cheng and Robert Zahler
An exemplary new volume that covers a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high-throughput screening ‘hits’ to rational structure-based design. The chapters include ‘follow-ons’ and ‘next generation’ compounds. The case studies survey the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology including proof-of-concept in the clinic for novel biological targets. Case studies include recently approved and marketed drugs, but also chronicle ‘near misses’, i.e. exemplary compounds that may have proceeded into the clinic but for various reasons did not result in a successful registration.
http://www.rsc.org/shop/books/2010/9781849731263.asp
