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Introducing Biomaterials Science Editorial Board Member Patrick S. Stayton

05 Dec 2012

Prof. Patrick S. Stayton, Editorial Board member

Patrick Stayton currently serves as the Washington Research Foundation Professor in the Department of Bioengineering at the University of Washington. He is the founding Director of the Institute for Molecular Engineering and Sciences, and the Center for Intracellular Delivery of Biologics. He received his B.S. in Biology (summa cum laude) from Illinois State University in 1984, his Ph.D. in Biochemistry from the University of Illinois in 1989, and was a Postdoctoral Research Associate at the Beckman Institute for Advanced Science and Technology, also at the University of Illinois.

Dr. Stayton’s eclectic research group works at the interface of fundamental molecular science and applied molecular bioengineering. His laboratory has fundamental projects aimed at elucidating the basic principles underlying biomolecular recognition, and connected projects applying these principles to medical applications in the drug delivery, medical diagnostics, and regenerative medicine fields. He has published over 200 scientific papers. Dr. Stayton has a strong interest in translating the group’s research, has been awarded several patents, and is a co-founder of the startup companies PhaseRx Inc. based on his group’s biologic drug delivery work, and Nexgenia based on their diagnostic work.

Dr. Stayton has been elected as a Fellow of the American Institute for Medical and Biological Engineering, and has been the recipient of the Clemson Award from the Society For Biomaterials and the CRS-Cygnus Recognition Award from the Controlled Release Society. He served as Co-Chair of the Gordon Conference on Drug Carriers in Medicine and Biology in 2010. He has also been awarded the 2009 Faculty Research Innovation Award, UW College of Engineering, and the Distinguished Teacher and Mentor Award from the Department of Bioengineering.

Biomaterials Science is now accepting submissions. All articles will be free to access until the end of 2014. Please contact the editorial office if you have any questions about the journal.

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Biomaterials Science Issue 1 now online!

22 Nov 2012

Less than a year after the launch announcement, the first issue of Biomaterials Science is now available online. Showcasing the latest biomaterials research, Issue 1 contains articles on the following:

Enzyme responsive materials, Rein V. Ulijn et al.: This review summarises recent advances in enzyme responsive material development, highlighting design strategies and future challenges in the field.

Bone repair using bioceramics, María Vallet-Regí et al.: Understanding natural ossification mechanisms is essential for designing scaffolds for bone tissue engineering. Mesoporous bioactive ceramics formed scaffolds by rapid prototyping and are excellent candidates for bone regeneration.

Zn and Sr substitution in tricalcium phosphate on osteoclast differentiation and resorption, Susmita Bose et al.: Tunable osteoclast cell differentiation and resorption of β-TCP bone substitute was achieved by Zn and/or Sr doping—a much needed property for successful bone remodelling.

A bio-inspired neural environment to control neurons, Morgan R. Alexander et al.: Chemical and micro-topographical gradients are used as a high-throughput means to assess neural cell interaction. Surface conditioning by radial glial cells enhances neuron attachment and alignment.

All articles published in Biomaterials Science are free to access online to all individuals who sign up for an RSC Publishing personal account, and all the existing RSC customers with an IP address registered.

Like what you read? Submit your work to Biomaterials Science now. Your articles will benefit from wide exposure with free access upon registration to all content published during 2013 and 2014 giving maximum visibility to your work.

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Hot paper: Bio-ink for printing living cells on demand

13 Nov 2012

A bio-ink to print living cells onto a surface using a commercial printer has been developed by Dr Marc in het Panhuis and colleagues at the University of Wollongong, Australia. Bioprinting can be used for tissue engineering and analytical applications. The bio-ink consists of a gel – gellan gum – that’s used in food additives. The gel makes sure that the cells in the bio-ink remain suspended with no sign of aggregation, which was the problem with previous inks. Aggregation means an uneven distribution of cells being printed out onto a surface.

Bio-ink for printing living cells on demand

Biomater. Sci., 2012, Advance Article. DOI: 10.1039/c2bm00114d

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Nasal gel alternative to insulin injection: Biomaterials Science article in Chemistry World

12 Nov 2012

The formulation affects the controlled delivery of insulin, demonstrated by a reduction in blood glucose over 24 hours. © Shutterstock

An international team of scientists has developed a novel insulin delivery system for nasal administration. The study aims to provide an alternative to regular injections through the delivery of insulin via the nasal membrane in the form of a hydrogel. This route offers a relatively high bioavailability, avoidance of the first-pass effect (in which a drug’s concentration is reduced before it reaches the systemic circulation) and painless administration.

Considerable research effort has been dedicated to developing alternative non-invasive insulin delivery systems, including oral and transcutaneous administration. The major limitations of nasal delivery are the rapid mucociliary clearance of a drug to the nasopharynx, resulting in a short time span for its absorption, and the low permeability of the nasal membrane to peptides such as insulin because of tight junctions between epithelial cells.

Read the full article by Michael Parkin in Chemistry World.

A once-a-day dosage form for the delivery of insulin through the nasal route: in vitro assessment and in vivo evaluation
H. Nazar , P. Caliceti , B. Carpenter , A. I. El-Mallah , D. G. Fatouros , M. Roldo , S. M. van der Merwe and J. Tsibouklis
Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C2BM00132B

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Ink containing living cells to print tissue: Biomaterials Science article in Chemistry World

07 Nov 2012

Scientists in Australia are a step closer to printing living cells for tissue engineering with the development of a new bio-ink that allows the cells to stay alive until they are printed and not clog up the printer nozzle.

‘The first bio-inks used in drop-on-demand cell printing were simple salt solutions,’ says Marc in het Panhuis, who was part of the research team at the University of Wollongong. ‘The cells in these inks settled and aggregated quickly, which impeded printing. Cell viability can also be compromised if the salt concentration is too high.’

Read the full article in Chemistry World.

Bio-ink for on-demand printing of living cells
Cameron J. Ferris, Kerry J. Gilmore, Stephen Beirne, Donald McCallum, Gordon G. Wallace and Marc in het Panhuis
Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C2BM00114D

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A cancer treatment that goes further

10 Oct 2012

A cancer treatment that uses titanium dioxide nanoparticles to kill tumour cells has been given a sound revamping by researchers in Japan. The new strategy improves the stability of the nanoparticles and the treatment may be able to penetrate more deeply into human tissues than ever before, targeting problematic tumours, through the use of ultrasound.

Atsushi Harada and colleagues at Osaka Prefecture University encapsulated the titanium dioxide nanoparticles inside micelles (an aggregate of surfactant molecules dispersed in a liquid colloid). The team grafted polyethylene glycol, a polymer with many medical uses, onto the micelles to stabilise them, improve their biocompatibility and to ensure that the micelles had negligible cytotoxicity. ‘Low cytotoxicity is the most important property of our micellar system’ Harada explains.

Titanium dioxide nanoparticle-entrapped micelles can selectively kill cells at only the ultrasound-irradiated area

Read the full article at Chemistry World.

Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy
Atsushi Harada, Masafumi Ono, Eiji Yuba and Kenji Kono
Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C2BM00066K

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Profile of the Institute for Integrated Cell-Material Sciences

05 Oct 2012

Now that we have published our first few articles, I thought this might be a good time to tell you a little more about the Institute for Integrated Cell-Material Sciences (WPI-iCeMS). Biomaterials Science is a collaborative venture between RSC Publishing and the iCeMS, which is based at Kyoto University, Japan.

The iCeMS is part of the Japanese government’s World Premier International Research Center (WPI) Initiative, launched in 2007 to forge a new model for scientific institutions, helping Japan lead the world in a broad range of leading-edge research. By merging materials science and cell biology, both fields of great strength at Kyoto University, the iCeMS is creating a new cross-discipline, supported by an advanced research environment and infrastructure that are unprecedented in Japan. The institute’s focus is on two main areas: stem cell science & technology and mesoscopic science & technology. The institute’s work draws from the life sciences, chemistry, materials science, as well as physics, constantly expanding the boundaries of technological innovation.

To find out more visit: www.icems.kyoto-u.ac.jp or www.facebook.com/Kyoto.Univ.iCeMS.

Biomaterials Science is now accepting submissions. All articles will be free to access until the end of 2014. Please contact the editorial office if you have any questions about the journal.

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Accepted Manuscript option is now available for Biomaterials Science

04 Oct 2012

Did you know that you can now choose for your Biomaterials Science manuscript to be published as an Accepted Manuscript.

An Accepted Manuscript is an unedited and unformatted version of an article that is published shortly after acceptance. This free service allows authors to make their results available to the community, in citable form, before publication of the edited article. It is available as a downloadable PDF file. It is then replaced by the fully edited and formatted Advance Article.

For more information please read our dedicated webpage.

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Biomaterials Science – new Advanced Articles

26 Sep 2012

Understanding the role of nano-topography on the surface of a bone-implant

This review by Walboomers and co-authors discusses the interaction of cells with the nano-topographical features of bone implants. The review also details the characterisation of implant surfaces and their manufacture.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00032f, Advance article)

Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy

The main cytotoxic agent in photodynamic therapy is believed to be the reactive oxygen species ¹O₂ which is used to treat cancerous diseases. In this paper, Harada and co-workers investigate the generation of reactive oxygen species using sonication of TiO₂ nanoparticles. They first synthesised TiO₂ nanoparticle-entrapped micelles with a core-shell structure. The nanoparticles were able to generate reactive oxygen species by sonication when inside the micelles. The frequently of sonication was appropriate for clinical situations, thus they has the potential to be used in sonodynamic therapy.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00066k, Advance article)

A progressive approach on inactivation of bacteria using silver–titania nanoparticles

The antibacterial properties of silver compounds have long been known. In this paper by Li, Luo and Bashir, Ag-decorated TiO₂ nanoparticles were prepared by a colloidal chemistry method. The nanoparticles were coincubated with model microbes, that are found in water, to investigate their biocidal effectiveness. The bactericidal mechanism was also investigated with a focus on the role of the microbial outer membrane.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00010e, Advance article)

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Biomaterials Science Blog

Archive for the ‘News’ Category

Introducing Biomaterials Science Editorial Board Member Patrick S. Stayton

Biomaterials Science Issue 1 now online!

Hot paper: Bio-ink for printing living cells on demand

Nasal gel alternative to insulin injection: Biomaterials Science article in Chemistry World

Ink containing living cells to print tissue: Biomaterials Science article in Chemistry World

More advance articles published

A cancer treatment that goes further

Profile of the Institute for Integrated Cell-Material Sciences

Accepted Manuscript option is now available for Biomaterials Science

Biomaterials Science – new Advanced Articles

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