Author Archive

We are very pleased to announce that Professor Won Jong Kim has joined Biomaterials Science as an Associate Editor

Profile picture of Won Jong KimWon Jong Kim has been appointed as a new Associate Editor for Biomaterials Science. Won Jong Kim is a Mueunjae chaired professor at the Department of Chemistry, Pohang University of Science and Technology (POSTECH). His research is mainly focused on synthesizing polymeric drug/gene carriers, DNA nanomedicines, developing new chemistries for the polymeric carriers and nanobiomaterials including exploring their potential towards efficient delivery. His current works also include control of gas molecules such as nitric oxide (NO) and its application for the treatment of malignant cancer, autoimmune disease, and brain disease. He has received multiple awards including the Korean Chemical Society (KCS)-Wiley Chemist Award, the Wiley-Polymer Society of Korea (PSK) Scientist Award, the KCS-Award for the Advancement of Science and the PSK-Mid-career Researcher Academy Award. Read more on his group webpage.

 

Won Jong has given his insight and thoughts on the future of the biomaterials field:

“Biomaterials can significantly augment cellular functionality and current imaging techniques, which would likely lead to practical and more advanced biomedical applications. To this end, future biomaterials research should be multi/interdisciplinary by playing essential roles to bridge the gap between each discipline, including nanotechnology, cell engineering, and medical imaging.”

“The journal, Biomaterials Science, will introduce innovative approaches that combine multiple disciplines, thus expanding opportunities for future biomaterials to be explored by researchers working on different fields.”

 

Editor’s choice: Won Jong’s favourite Biomaterials Science articles

Here are a couple of publications that Won Jong has chosen as his favourite recent articles in Biomaterials Science.

 

Graphical abstract image depicting immunotherapy delivery to cellsA low-intensity focused ultrasound-assisted nanocomposite for advanced triple cancer therapy: local chemotherapy, therapeutic extracellular vesicles and combined immunotherapy
Mixiao Tan, Yuli Chen, Yuan Guo, Chao Yang, Mingzhu Liu, Dan Guo, Zhigang Wang, Yang Cao and Haitao Ran
Biomaterials Science, 2020, 8, 6703-6717

 

 

Graphical abstract image depicting in cartoon form phototherapy and in combination with immunotherapyBiomaterial-assisted photoimmunotherapy for cancer
Muchao Chen and Qian Chen
Biomaterials Science, 2020, 8, 5846-5858

 

 

 

 

All these articles are currently FREE to read until 5th April 2021!

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We are very pleased to announce Professor Jianjun Cheng as the new Editor-in-Chief for Biomaterials Science

Profile photo of Professor Jianjun ChengJianjun Cheng has been appointed as the new Editor-in-Chief for Biomaterials Science, taking over from Professor Jennifer Elisseeff, after serving as an Associate Editor for Biomaterials Science for over seven. Jianjun Cheng is the Hans Thurnauer Professor of Materials Science and Engineering and Professor of Chemistry and Bioengineering at the University of Illinois at Urbana-Champaign, USA. He is a Fellow of the National Academy of Inventors, Fellow of the American Association for the Advancement of Science, Fellow of the American Institute for Medical and Biological Engineering, and Fellow of the American Chemical Society Division of Polymer Chemistry. His research focuses on developing polymeric and nanomaterials for biomedical applications, such as functional polypeptides, nanomedicines for drug and gene delivery, cell labelling for in vivo targeting and controlled release bionanomaterials. Read more on his group webpage.

 

Learn more about Jianjun by reading some of his research articles below!

 

Graphical abstract depicting selective cancer cell labeling and bioorthogonal click reaction followed by injection into a tumour bearing illustrated mouseCancer cell-targeted cisplatin prodrug delivery in vivo via metabolic labeling and bioorthogonal click reaction
Xun Liu, Fan Wu, Kaimin Cai, Ziyin Zhao, Zhimin Zhang, Wongbing Chen, Yong Liu, Jianjun Cheng and Lichen Yin
Biomaterials Science, 2021, DOI: 10.1039/D0BM01709D

 

 

 

Graphical abstract depicting the architecture change of glatiramer acetate (GA) to star shaped GA and a plot of EAE score v day post-immunisation for these compounds plus a controlInduction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in an animal model of multiple sclerosis
Ziyuan Song, Yee Ming Khaw, Lazaro Pacheco, Kuan-Ying Tseng, Zhengzhong Tan, Kaimin Cai, Ettigounder Ponnusamy, Jianjun Cheng and Makoto Inoue
Biomaterials Science, 2020, 8, 5271-5281

 

 

Graphical abstract depicting a azido-galactose modified HCC membrane followed by attachment of a DBCO labelled agentAzido-galactose outperforms azido-mannose for metabolic labeling and targeting of hepatocellular carcinomaHua Wang, Yang Liu, Ming Xu and Jianjun Cheng
Biomaterials Science, 2019, 7, 4166-4173

 

 

Graphical abstract depicting the interaction of a cancer cell with the immune systemRecent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy
Yeling Mai, Ruibo Wang, Wei Jiang, Yang Bo, Tengfei Zhang, Julin Yu, Ming Cheng, Yunzi Wu, Jianjun Cheng and Wang Ma
Biomaterials Science, 2019, 7, 2640-2651

 

 

 

 

All these articles are currently FREE to read until 15th March 2021!

 

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STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening

Total hip arthroplasty (THA) is required in orthopaedic surgery mostly for treating end stage joint disease. A good number of patients (9.1%) require revision surgeries due to aseptic loosening, which means osteolysis around the prostheses caused by the generation of wear particles. Now, there are two established mechanisms to understand wear induced osteolysis: wear particles produce inflammatory cytokines and activated osteoclasts; and wear particles disturb the differentiation, survival and function of osteoblasts and osteoclasts. However, the mechanism of interaction between osteoblasts and osteoclasts and the influence of wear particles is not clearly understood.

The schematic illustration of TiAl6V4 nanoparticle induced activation of the STAT3/IL-6 pathway resulting in the activation of osteoclast and osteolysis, which can be inhibited by CP690,550

Researchers from China sought to analyze the role of interleukin-6 (IL-6) dependent inflammatory response in osteoblasts treated with TiAl6V4 nanoparticles (TiPs) and also the protective action of IL-6/STST3 (an important transcription factor) inhibition. TiPs obtained from the prosthesis of a patient with aseptic loosening were characterized for shape, size distribution, chemical composition, etc.

As measured by real time-PCR, the expression of IL-6, IL-11, LIF and OSM all increased when MC3T3-E1 cells were stimulated by TiPs in vitro as well as in the periosteum of mice. It was also found via western blotting that the protein levels of activated STAT3 were upregulated following treatment of cells with TiPs in a time and dose dependent fashion. This corroborated the immunofluorescence staining results both in vitro and in vivo, thereby confirming that TiPs activate STAT3 expression in osteoblasts. By using CP690,550 as an inhibitor of STAT3 activation, it was found that upregulation of IL-6- and IL-6-dependent inflammatory cytokine expression was reduced.

Next, using real-time PCR, it was shown that mRNA expression of RANKL, an indicator of osteoclastogenesis increased 13 fold in osteoblasts stimulated by TiPs. Using micro-CT with 3-dimensional reconstruction and quantitative analysis of bone parameters, it was confirmed that inhibition of the STAT3/ IL-6 pathway by inhibitor CP690,550 resulted in suppression of TiP induced osteolysis.

All these results taken together suggest that TiPs induced activation of STAT3 which led to osteolysis by promoting inflammation in osteoblasts and activating osteoclasts and that the inhibition of STAT3 activation by CP690,550 (tofacitinib) significantly reduced the activation of osteoclasts and protected against osteolysis via the STAT3/IL-6 signalling pathway. This suggests use of tofacitinib as a potential therapy for aseptic loosening.

To find out more please read:

STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening

Biomaterials Science, 2020, DOI: 10.1039/D0BM01256D

 

About the web writer:

Saswat Choudhury is a graduate student at the Indian Institute of Science Bangalore pursuing research on biomaterials and tissue engineering. He studies bioabsorbable polymers, design and characterization for biomedical applications. Besides research, he is also interested in science communication. You can find him on Twitter @saswatchoudhur1

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Open for Nominations: 2021 Biomaterials Science Lectureship

 

Do you know an early-career researcher who deserves recognition for their contribution to the biomaterials field?

Now is your chance to put them forward for the accolade they deserve!

Biomaterials Science is pleased to announce that nominations are now being accepted for its 2021 Lectureship award. This annual award was established in 2014 to honour an early-stage career scientist who has made a significant contribution to the biomaterials field.

The recipient of the award will be asked to present a lecture at European Society for Biomaterials Annual Meeting in Porto in September 2021, where they will also be presented with the award. The Biomaterials Science Editorial Office will provide £1000 financial support to the recipient for travel and accommodation costs.

The recipient will also be asked to contribute a research article to the journal and will have their work showcased free of charge on the front cover of the issue in which their article is published. The article would be subject to the normal peer review standards of the journal.

 

Previous winners

2020 – Kanyi Pu, Nanyang Technological University, Singapore

2019 – April Kloxin, University of Delaware, USA

2018 – Zhen Gu, University of North Carolina at Chapel Hill & North Carolina State University, USA

2017 – Zhuang Liu, Soochow University, China

2016 – Fan Yang, Stanford University, USA

2015 – Joel Collier, Duke University, USA

2014 – Suzie Pun, University of Washington, USA

 

Eligibility

To be eligible for the lectureship, candidates should meet the following criteria:

  • Be an independent researcher, having completed PhD and postdoctoral studies
  • Be actively pursuing research within the biomaterials field, and have made a significant contribution to the field
  • Be at an early stage of their independent career (this should be within 12 years of attaining their doctorate or equivalent degree, but appropriate consideration will be given to those who have taken a career break or followed an alternative study path)

Although the Biomaterials Science Lectureship doesn’t explicitly reward support of or contributions to the journal, candidates with a history of publishing or reviewing for the journal would be more likely to be considered favourably.

 

Selection

  • All eligible nominated candidates will be assessed by a shortlisting panel, made up of members of the Biomaterials Science Advisory Board and a previous lectureship winner.
  • The shortlisting panel will consider the nomination form and letter of recommendation, as well as the three recent research articles highlighted in the nomination form for consideration.
  • Shortlisted candidates will be further assessed by the Biomaterials Science Editorial Board, and a winner will be selected based on an anonymous poll.
  • Selection is not based simply on quantitative measures. Consideration will be given to all information provided in the letter of recommendation and nomination form, including research achievements and originality, contributions to the biomaterials community, innovation, collaborations and teamwork, publication history, and engagement with Biomaterials Science.

 

Nominations

Nominations must be made via email to biomaterialsscience-rsc@rsc.org, and include the following:

  • A brief letter of recommendation (1 page maximum length)
  • A complete nomination form (includes list of the candidate’s relevant publications or recent work, 3 research articles to be considered during the shortlisting process, candidate’s scientific CV, and full contact details)

Please note:

  • Nominations from students and self-nomination is not permitted.
  • The nominee must be aware that he/she has been nominated for this lectureship.
  • As part of the Royal Society of Chemistry, we have a responsibility to promote inclusivity and accessibility in order to improve diversity. Where possible, we encourage each nominator to consider nominating candidates of all genders, races, and backgrounds. Please see the RSC’s approach to Inclusion and Diversity.
  • Candidates outside of the stated eligibility criteria may still be considered.

 

Nominations deadline: 30th November 2020

                                                               

Download nomination form here

 

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Oversized composite braided biodegradable stents with post-dilatation for pediatric applications: mid-term results of a porcine study

Biodegradable stents (BDSs) have proven to be better compared to permanently implanted metallic stents for the treatment of endovascular diseases in children.  Currently, BDSs that are made out of polylactic acid (PLA) with degradation times of 2–3 years are not suitable for infants, where the ideal healing time for an artery is 3 to 6 months. Poly p-dioxanone (PPDO) is an ideal alternative owing to its availability, FDA approval in clinics and suitable degradation time of 6 months.  But, braided PPDO fiber stents still have lower stiffness than standard self-expanding metal ones.

Researchers from China have come up with a novel design strategy to reinforce the mechanical properties of PPDO fibers by using an elastomeric polycaprolactone (PCL) coating which can serve as a binder at to improve the compression performance. This self-expandable, fiber-based, composite braided biodegradable stent (CBBS) made of PPDO and PCL was then assessed for its physical properties, changes in mechanical properties during degradation, etc and compared with the control, cobalt–chromium-based alloy self-expanding stents (WALLSTENTs/WSs). CBBSs delivered in sheaths post dilation exhibited similar mechanical properties as WSs.

In vitro degradation studies showed that CBBSs post-dilation retained effective mechanical support and stent weight (almost 90%) for at least 16 weeks, which is adequate for arterial healing. These results corroborate with the hydrolysis mechanisms involved in degradation of PDDO, the main component and with in vivo histopathological evaluation.

Lastly, the stents were implanted in porcine models without resulting in any evidence of complications such as implant migration, thrombosis, dissection or aneurism. The mechanical performance of CBBS was also not worse than metallic stents in vivo. Angiographic analysis revealed vessel stenosis and an inflammatory response (intima proliferation) at 4 months due to hydrolysis induced degradation of the stent. But this inflammation was resolved at 12 months due to the complete degradation of CBBSs unlike the WSs. When different diameters of WSs were compared, the ones in oversized common iliac arteries exhibited higher luminal gain initially but there was stenosis and vascular injury compared to normal-sized abdominal aortas in the mid-term follow-up period

All the results combined demonstrate the advantages of these novel composite braided degradable stents over the standard metallic ones in terms of mechanical strength and appropriate degradation rate.

To find out more please read:

Oversized composite braided biodegradable stents with post-dilatation for pediatric applications: mid-term results of a porcine study

Jing Sun, Kun Sun,  Kai Bai, Sun Chen, Fan Zhao, Fujun Wang, Nanchao Honga and Hanbo Hu

Biomaterials Science, 2020, DOI: 10.1039/d0bm00567c

 

About the web writer:

Saswat Choudhury is a graduate student at the Indian Institute of Science Bangalore pursuing research on biomaterials and tissue engineering. He studies bioabsorbable polymers, design and characterization for biomedical applications. Besides research, he is also interested in science communication. You can find him on Twitter @saswatchoudhur1

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