Analytical Methods Blog

Highlights of Issue 2

08 Feb 2012

Featured in the latest issue: a Critical Review on magnetic resonance techniques and a number of HOT articles, which will be free to access until the end of February. Don’t forget to take a look at the issue in full via the journal homepage.

Critical Review: Low field magnetic resonance techniques in the development of nanomaterials for biomedical applications
Carla J. Meledandri and Dermot F. Brougham
Anal. Methods, 2012, 4, 331-341
DOI: 10.1039/C2AY05420E

Communication: Engineering a unimolecular multifunctional DNA probe for analysis of Hg²⁺ and Ag⁺
Xiaoxiao He, Zhihe Qing, Kemin Wang, Zhen Zou, Hui Shi and Jin Huang
Anal. Methods, 2012, 4, 345-347
DOI: 10.1039/C2AY05823E

Communication: Simultaneous determination of two important dopamine metabolites at physiological pH by voltammetry
S. Brillians Revin and S. Abraham John
Anal. Methods, 2012, 4, 348-352
DOI: 10.1039/C2AY05664J

Communication: A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry
Cai Tie and Xin-Xiang Zhang
Anal. Methods, 2012, 4, 357-359
DOI: 10.1039/C2AY05741G

Communication: A graphene oxide–rhodamine 6G nanocomposite as turn-on fluorescence probe for selective detection of DNA
Xue Wang, Shuhua Zhong, Yu He and Gongwu Song
Anal. Methods, 2012, 4, 360-362
DOI: 10.1039/C2AY05827H

Arsenic species and selected metals in human urine: validation of HPLC/ICPMS and ICPMS procedures for a long-term population-based epidemiological study
Jürgen Scheer, Silvia Findenig, Walter Goessler, Kevin A. Francesconi, Barbara Howard, Jason G. Umans, Jonathan Pollak, Maria Tellez-Plaza, Ellen K. Silbergeld, Eliseo Guallar and Ana Navas-Acien
Anal. Methods, 2012, 4, 406-413
DOI: 10.1039/C2AY05638K

Monitoring intracellular nitric oxide production using microchip electrophoresis and laser-induced fluorescence detection
Emilie R. Mainz, Dulan B. Gunasekara, Giuseppe Caruso, Derek T. Jensen, Matthew K. Hulvey, Jose Alberto Fracassi da Silva, Eve C. Metto, Anne H. Culbertson, Christopher T. Culbertson and Susan M. Lunte
Anal. Methods, 2012, 4, 414-420
DOI: 10.1039/C2AY05542B

Multivariate calibration of near-infrared spectra by using influential variables
Xueguang Shao, Min Zhang and Wensheng Cai
Anal. Methods, 2012, 4, 467-473
DOI: 10.1039/C2AY05609G

Mass spectrometric imaging as a high-spatial resolution tool for functional genomics: Tissue-specific gene expression of TT7 inferred from heterogeneous distribution of metabolites in Arabidopsis flowers
Andrew R. Korte, Zhihong Song, Basil J. Nikolau and Young Jin Lee
Anal. Methods, 2012, 4, 474-481
DOI: 10.1039/C2AY05618F

A simple and sensitive colorimetric method for detection of mercury ions based on anti-aggregation of gold nanoparticles
Tingting Lou, Ling Chen, Chunrong Zhang, Qi Kang, Huiyan You, Dazhong Shen and Lingxin Chen
Anal. Methods, 2012, 4, 488-491
DOI: 10.1039/C2AY05764F

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Analytical Methods Issue 2 online

07 Feb 2012

By Vibhuti Patel, Deputy Editor.

Front cover image, Analytioal Methods, Volume 4, Issue 2

Front cover: Cizdziel et al., Anal. Methods, 2012, 4, 564-569

Take a look at the latest issue of Analytical Methods, now available online.

The stunning front cover highlights work from James Cizdziel of the University of Mississippi, and colleagues.

They evaluate the use of multiple botanical reference materials as LA-ICP-MS standards for quantifying the spatial distribution of elements in desert leaves.

Determination of elements in situ in green leaves by laser ablation ICP-MS using pressed reference materials for calibration
James Cizdziel, Kaixuan Bu and Piotr Nowinski
Anal. Methods, 2012, 4, 564-569
DOI: 10.1039/C1AY05577A

The inside front cover features a sensitive and selective analytical method utilising LC-ESI-MS/MS for the semi-quantitative determination of biogenic amines and amino acids in porcine decomposition fluid.

This paper is from Simon Lewis and colleagues from Curtin University, Perth, Australia, and was highlighted as a HOT article when it first appeared online.

Inside front cover image, Analytical Methods, Volume 4, Issue 2

Inside front cover: Swann et al., Anal. Methods, 2012, 4, 363-370

Determination of amino acids and amines in mammalian decomposition fluid by direct injection liquid chromatography-electrospray ionisation-tandem mass spectrometry
Lisa M. Swann, Francesco Busetti and Simon W. Lewis
Anal. Methods, 2012, 4, 363-370
DOI: 10.1039/C1AY05447C

Both articles will be free to access for 6 weeks.

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Using blood, not urine, to diagnose kidney stones

02 Feb 2012

By Vibhuti Patel, Deputy Editor.

A method to diagnose urinary lithiasis at an early stage has been devised by Wei Hang and colleagues in Xiamen, China. The method can also distinguish between the different types of stone, which is important when considering treatment options.

Currently, distinguishing between types can only be done after the stones have been removed from a patient, making it difficult to prescribe a treatment.

Urinary lithiasis, stones in the lower urinary tract, has become more common, with about 100,000 new cases each year. It causes substantial pain and leads to renal failure. The stones are caused by a build up of organic materials and inorganic crystals.

The team’s diagnostic method uses elemental analysis on blood serum samples to detect the levels of barium, gallium, antimony and sodium; variations from the norm are linked to the appearance of stones. The test subjects could then be subdivided into calcareous and non-calcareous stone patients by metallomic profiling, and the team found that selenium levels play a major role in this classification.

Diagnosis of kidney stones by elemental analysis of blood samples

Gao et al., Anal. Methods, 2012

Compared with urine samples, blood serum samples show smaller variability under normal physiological conditions so are a better choice for elemental screening, say the researchers.

Early diagnosis of urinary lithiasis via elementary profile of serum samples
Yao Gao, Ning Yang, Xiaomei Yan, Wei Hang, Jinchun Xing, Jiaxin Zheng, Eryi Zhu and Benli Huang
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY05705K

You may also be interested in:

Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer
Lin Lin, Quan Yu, Xiaomei Yan, Wei Hang, Jiaxin Zheng, Jinchun Xing and Benli Huang
Analyst, 2010, 135, 2970-2978
DOI: 10.1039/C0AN00265H

Critical Review: Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations
Alessandra Sussulini and Johanna Sabine Becker
Metallomics, 2011, 3, 1271-1279
DOI: 10.1039/C1MT00116G

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New avenues for platelet study: unlocking the P2X1 receptor

01 Feb 2012

By Vibhuti Patel, Deputy Editor.

Anderson et al., Anal. Methods, 2012, 4, 101-105

Dana Spence and colleagues at Michigan State University have developed a way to study the P2X1 receptor on platelets, providing new possibilities for the research of these important cells.

The primary function of platelets in the bloodstream involves maintaining hemostasis and preventing blood loss through the clotting process.

Platelets are found in the bloodstream and function to maintain hemostasis and prevent blood loss via clotting. Adenine receptors on the surface of the platelet are important in this process, most notably the ADP-sensitive receptors P2Y1/P2Y12, and the ATP-sensitive P2X1 receptor.

Roles for P2Y-type receptors in platelet activation are well established, but the role of the P2X1 receptor is less clear as it has proven difficult to study. P2X1 is rapidly desensitised during in vitro experiments, particularly when the platelets have been separated from plasma and washed.

Professor Dana Spence, Michigan State University, USA

Here, Professor Spence – who is on the Advisory Board of Analytical Methods‘ sister journal, Analyst – and his team use the reported P2X1 inhibitor NF449 to sensitise washed platelets, enabling them to be properly studied.

In a press release from MSU, Professor Spence says, “This receptor, P2X1, has long been viewed as not important in platelets; our studies show that is not necessarily true. The receptor is very active; you just need to be careful in working with it.”

He hopes that this now opens up investigation of the P2X1 receptor as a potential drug target for the treatment of conditions such as diabetes and hypertension.

Read the paper in full:

Measuring P2X1 receptor activity in washed platelets in the absence of exogenous apyrase
Kari B. Anderson , Welivitiya Karunarathne and Dana M. Spence
Anal. Methods, 2012, 4, 101-105
DOI: 10.1039/C1AY05530E

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Developments and applications of electrophoresis

12 Jan 2012

By Mary Badcock, Deputy Editor.

Electrophoresis is a very useful separation method employed in a great variety of applications, including the separation and analysis of biological samples (e.g. DNA and proteins) and environmental samples (e.g. pesticide or pollutant analysis). Electrophoresis comes in various different forms (capillary or gel electrophoresis for example) making it a very versatile and adaptable technique.

Analytical Methods presents an excellent forum for advances and applications of this technique, and below is a sample of the high-quality work we have published in this area. These articles are free to access until the 13th February 2012 so make the most of this and take a look!

And don’t forget to stay informed of all our latest content by signing up to our e-alert or following us on Twitter: @methodsrsc and @analystrsc.

EndoV/DNA ligase mutation scanning assay using microchip capillary electrophoresis and dual-color laser-induced fluorescence detection, Akira Kotani, Małgorzata A. Witek, John K. Osiri, Hong Wang, Rondedrick Sinville, Hanna Pincas, Francis Barany and Steven A. Soper, Anal. Methods, 2012, 4, 58-64

Thermally responsive polymer as a sieving matrix of proteins in capillary gel electrophoresis, Chun Yang, Chunyan Chang, Jun Wang, Qishu Qu, Xiaoya Hu and Yang Wang, Anal. Methods, 2011, 3, 2717-2720

Assay design considerations for use of affinity aptamer amplification in ultra-sensitive protein assays using capillary electrophoresis, Kris P. F. Janssen, Karel Knez, Jeroen Pollet, Scott J. Roberts, Jan Schrooten and Jeroen Lammertyn, Anal. Methods, 2011, 3, 2156-2159

Recent advances of enantioseparations in capillary electrophoresis and capillary electrochromatography, Huang Lu and Guonan Chen, Anal. Methods, 2011, 3, 488-508

Rapid speciation analysis of mercury by short column capillary electrophoresis on-line coupled with inductively coupled plasma mass spectrometry, Bao-Hui Li, Anal. Methods, 2011, 3, 116-121

Rapid prototyping of polymeric electrophoresis microchips with integrated copper electrodes for contactless conductivity detection, Wendell Karlos Tomazelli Coltro, José Alberto Fracassi da Silva and Emanuel Carrilho, Anal. Methods, 2011, 3, 168-172

Speciation of organotin compounds in environmental samples with semi-permanent coated capillaries by capillary electrophoresis coupled with inductively coupled plasma mass spectrometry, Jing Sun, Bin He, Yongguang Yin, Lu Li and Guibin Jiang, Anal. Methods, 2010, 2, 2025-2031

Determination of paraquat and diquat preconcentrated with N doped TiO₂nanotubes solid phase extraction cartridge prior to capillary electrophoresis, Qingxiang Zhou, Jinli Mao, Junping Xiao and Guohong Xie, Anal. Methods, 2010, 2, 1063-1068

Ionic liquids in the assay of proteins, Xuwei Chen, Jiawei Liu and Jianhua Wang, Anal. Methods, 2010, 2, 1222-1226

Ionic mobility of the solvated proton and acid–base titration in a four-compartment capillary electrophoresis system, Renata Mayumi Saito, José Geraldo Alves Brito-Neto, Fernando Silva Lopes, Lucas Blanes, Eric Tavares da Costa, Denis Tadeu Rajh Vidal, Guilherme Minoru Hotta and Claudimir Lucio do Lago, Anal. Methods, 2010, 2, 164-170

Application of dispersive liquid–liquid microextraction combined with sweeping micellar electrokinetic chromatography for trace analysis of six carbamate pesticides in apples, Shuaihua Zhang, Chao Li, Shuangju Song, Tao Feng, Chun Wang and Zhi Wang, Anal. Methods, 2010, 2, 54-62

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L S Theobald Lectureship

11 Jan 2012

By Aliya Anwar.

The Analytical Methods Committee (AMC) are announcing the open nominations for the 2012 L S Theobald Lectureship. Information on the nominating process can be found here.

The LS Theobald Lectureship is awarded to someone who has made a significant contribution to analytical chemistry in an area relevant to the work of the Analytical Methods Committee. (The AMC is a sub-committee of the RSC Analytical Division) and its sub-committees. It is not a requirement that the recipient should be a member of the RSC or have contributed directly to the work of the AMC or its sub-committees.

The closing date for nominations is 31 January 2012.

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HOT articles in Issue 1

06 Jan 2012

By Vibhuti Patel, Deputy Editor.

Here at Analytical Methods we like to make it as easy as possible for you to access the latest high-impact analytical science. So, from now on we’ll let you know which HOT articles feature in each new issue. Look out for updates, and for longer posts on some of the most exciting new research published.

In Issue 1, you can enjoy the following HOT papers, which will be free to access for 2 weeks from Monday 9 January:

Critical Review: Capacitively coupled contactless conductivity detection on microfluidic systems — ten years of development
Wendell Karlos Tomazelli Coltro, Renato Sousa Lima, Thiago Pinotti Segato, Emanuel Carrilho, Dosil Pereira de Jesus, Claudimir Lucio do Lago and José Alberto Fracassi da Silva
Anal. Methods, 2012, 4, 25-33
DOI: 10.1039/C1AY05364G

Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study
Anisha Wijeyesekera, Philip A. Clarke, Magda Bictash, Ian J. Brown, Mark Fidock, Thomas Ryckmans, Ivan K. S. Yap, Queenie Chan, Jeremiah Stamler, Paul Elliott, Elaine Holmes and Jeremy K. Nicholson
Anal. Methods, 2012, 4, 65-72
DOI: 10.1039/C1AY05427A

In situ monitoring of polymer redox states by resonance μRaman spectroscopy and its applications in polymer modified microfluidic channels
Hella Logtenberg, Laurens-Jan C. Jellema, Maria J. Lopez-Martinez, Jetsuda Areephong, Elisabeth Verpoorte, Ben L. Feringa and Wesley R. Browne
Anal. Methods, 2012, 4, 73-79
DOI: 10.1039/C1AY05475A

Characterizing the dual-wavelength dye indo-1 for calcium-ion sensing under pressure
Jordan Ryan and Paul Urayama
Anal. Methods, 2012, 4, 80-84
DOI: 10.1039/C1AY05486D

A simple system for the measurement of the distribution of activities of individual molecules of E. coli β-galactosidase
Douglas B. Craig
Anal. Methods, 2012, 4, 85-88
DOI: 10.1039/C2AY05627E

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Issue 1 of 2012 now online

06 Jan 2012

By Vibhuti Patel, Deputy Editor.

Analytical Methods, 2012, Issue 1 front cover

Analytical Methods, 2012, 4(1): 1-314

Happy New Year! Our first issue of 2012 is now online for you to read.

On the front cover is work from Daniel Attinger of Columbia University, New York, USA and his colleagues from other US institutions.

Their study proposes that images of stains from 100-nanolitre drops can be automatically identified as signatures of fluid composition and substrate chemistry, which has implications for areas such as biological testing.

They used classification algorithms to identify unknown stains, and demonstrated a high level of accuracy.

Identification of fluid and substrate chemistry based on automatic pattern recognition of stains
Namwon Kim, Zhenguo Li, Cedric Hurth, Frederic Zenhausern, Shih-Fu Chang and Daniel Attinger
Anal. Methods, 2012, 4, 50-57
DOI: 10.1039/C1AY05338H

On the inside front cover, Akira Kotani of the Tokyo University of Pharmacy and Life Sciences, Japan, performed alongside international collaborators from the USA and Korea.

They report the ability to detect sporadic mutations with high sensitivity using a mutation scanning assay, which employs thermostable endonuclease V (EndoV) and DNA ligase.

Their microchip method is shown to be considerably faster than conventional capillary gel electrophoresis.

EndoV/DNA ligase mutation scanning assay using microchip capillary electrophoresis and dual-color laser-induced fluorescence detection
Akira Kotani, Małgorzata A. Witek, John K. Osiri, Hong Wang, Rondedrick Sinville, Hanna Pincas, Francis Barany and Steven A. Soper
Anal. Methods, 2012, 4, 58-64
DOI: 10.1039/C1AY05366C

Both these articles will be free to access for 6 weeks: enjoy!

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Analytical Methods Blog

Highlights of Issue 2

Analytical Methods Issue 2 online

Using blood, not urine, to diagnose kidney stones

New avenues for platelet study: unlocking the P2X1 receptor

Top ten most accessed articles in December

Developments and applications of electrophoresis

Top ten most accessed articles in November

L S Theobald Lectureship

HOT articles in Issue 1

Issue 1 of 2012 now online

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