Analytical Methods Issue 10 now online!

Wei et al., Anal. Methods, 2013, 5, 2440-2443

The latest issue of Analytical Methods is now available online. We have three beautiful covers featuring the most recent advances in the field of applied analytical chemistry.

Our outside front cover showcases the work of Xing-Jiu Huang and colleagues at the Chinese Academy of Sciences. The researchers introduce a new method to identify and quantify chlorobenzene micropollutants that are present in the natural environment. These pollutants have poor electrochemical activity and have been difficult to identify with electrochemical sensors. In this work, a novel ionic liquid–carbon nanotube composite sensor based on electrochemical impendance technique is proposed as an efficient sensor for micropollutants with poor electrochemical activity.

Ionic liquid–carbon nanotube composites as scaffolds in the determination of tetrachlorobenzene: electrochemical impedance technique
Yan Wei, Zhong-Gang Liu, Xing Chen, Jin-Huai Liu and   Xing-Jiu Huang
Anal. Methods, 2013, 5, 2440-2443 
DOI: 10.1039/C3AY00022B

Wolf and Reagen, Alnal. Methods, 2013, 5, 2444-2454

The wonderful inside front cover of this issue features the paper of Susan Wolf and William Reagen from the Environmental Laboratory 3M Centre, St. Paul, USA. In the study, the authors report a novel analytical method for analysis of perfluorinated compounds in water. In particular, they optimise and validate a technique based on pre-sampling isotope dilution-direct injection-liquid chromatography tandem mass spectrometry (DI-LC/MS/MS).

Method and validation for the analysis of perfluorinated compounds in water by pre-sampling isotope dilution-direct injection-LC/MS/MS
Susan T. Wolf and   William K. Reagen  
Anal. Methods, 2013, 5, 2444-2454
DOI: 10.1039/C3AY26347A

Zhang et al., Anal. Methods, 2013, 5, 2455-2460

Finally, the outside back cover of Issue 10 shows the research study of Zongxiu Nie and co-workers at the Chinese Academy of Sciences. In their work, the researchers present the rapid and direct detection of polyhydroxylated alkaloids in mulberry using leaf spray mass spectrometry and propose the leaf spray method for the rapid screening of lead compounds from natural plants during drug development.

Rapid detection of polyhydroxylated alkaloids in mulberry using leaf spray mass spectrometry
Ning Zhang, Yafeng Li, Yueming Zhou, Jian Hou, Qing He, Xiang-Guo Hu, Yue-Mei Jia, Chu-Yi Yu and   Zongxiu Nie 
Anal. Methods, 2013, 5, 2455-2460
DOI: 10.1039/C3AY00018D

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Top ten most accessed articles in March

This month sees the following articles in Analytical Methods that are in the top ten most accessed:-

Grafting of doxycycline imprinted polymers on silica surface for selective solid-phase extraction in beef samples 
Tao-jing Chen, Jing-chan Zhao, Zhi-an Guoa and Bai-xin Zhang 
Anal. Methods, 2012,4, 4237-4243 
DOI: 10.1039/C2AY26084K  

Peptide–quantum dot bioconjugates for label-free trypsin detection based on the exciton energy transfer 
Fen-Fen Zheng, Jian-Feng Wu and Guang-Chao Zhao  
Anal. Methods, 2012,4, 3932-3936 
DOI: 10.1039/C2AY25923K  

Photocatalytic reduction of CO2: a brief review on product analysis and systematic methods 
Jindui Hong, Wei Zhang, Jia Ren and Rong Xu  
Anal. Methods, 2013,5, 1086-1097 
DOI: 10.1039/C2AY26270C  

Simultaneous determination of dihydroxybenzene isomers using disposable screen-printed electrode modified by multiwalled carbon nanotubes and gold nanoparticles 
Da-Wei Li, Yuan-Ting Li, Wei Song and Yi-Tao Long   
Anal. Methods, 2010,2, 837-843 
DOI: 10.1039/C0AY00076K  

Facile and sensitive paper-based chemiluminescence DNA biosensor using carbon dots dotted nanoporous gold signal amplification label 
Yanhu Wang, Shoumei Wang, Shenguang Ge, Shaowei Wang, Mei Yan, Dejin Zang and Jinghua Yua   
Anal. Methods, 2013,5, 1328-1336 
DOI: 10.1039/C2AY26485D  

Electrochemical impedance spectroscopy: an overview of bioanalytical applications 
Edward P. Randviir and Craig E. Banks  
Anal. Methods, 2013,5, 1098-1115 
DOI: 10.1039/C3AY26476A  

Detection of apoptosis: A review of conventional and novel techniques 
Michelle M. Martinez, Randall D. Reif and Dimitri Pappas 
Anal. Methods, 2010,2, 996-1004 
DOI: 10.1039/C0AY00247J  

A novel camera phone-based platform for quantitative fluorescence sensing 
Stephen O’Driscoll, Brian D. MacCraith and Conor S. Burkea   
Anal. Methods, 2013,5, 1904-1908 
DOI: 10.1039/C3AY40116B  

Rhodamine and BODIPY chemodosimeters and chemosensors for the detection of Hg2+, based on fluorescence enhancement effects 
M. J. Culzoni, A. Muñoz de la Peña, A. Machuca, H. C. Goicoechea and R. Babiano  
Anal. Methods, 2013,5, 30-49 
DOI: 10.1039/C2AY25769F  

Non-enzymatic glucose sensor based on three dimensional nickel oxide for enhanced sensitivity 
Chunyan Guo, Yinmei Wang, Yongqing Zhao and Cailing Xu  
Anal. Methods, 2013,5, 1644-1647 
DOI: 10.1039/C3AY00067B  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analytical Methods? Then why not submit to us today or alternatively email us your suggestions.

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Analytical Methods Issue 9 now online!

Welcome to the latest issue of Analytical Methods!

We have a great new cover and a couple of HOT papers free for you to enjoy for the next four weeks. The outside front cover of this issue showcases the work of Monica Yang from Merck & Co., Inc. USA and colleagues at Eksigent, USA.

In their paper, the researchers present a liquid chromatography instrument for fast HPLC analysis, which provides good separation efficiency and system reproducibility. This system can be used efficiently for pharmaceutical analysis. Indeed, more than a dozen pharmaceutical components and related process impurities were resolved in 10 minutes on the micro LC instrument.

Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis
Monica (Mei) Yang, Xiaoyi Gong, Wes Schafer, Don Arnoldc and   Christopher J. Welch  
Anal. Methods, 2013,5, 2178-2181
DOI: 10.1039/C3AY26435A

Take a look at our HOT papers below, they will be free for you to read until May 21st.

Analytical techniques for single-liposome characterization
Chaoxiang Chen, Shaobin Zhu, Tianxun Huang, Shuo Wanga and   Xiaomei Yan
Anal. Methods, 2013,5, 2150-2157
DOI: 10.1039/C3AY40219C

Electrochemical sensing and biosensing based on square wave voltammetry
Aicheng Chen and   Badal Shah  
Anal. Methods, 2013,5, 2158-2173
DOI: 10.1039/C3AY40155C

DNA-stabilized silver nanoclusters with guanine-enhanced fluorescence as a novel indicator for enzymatic detection of cholesterol
Min Duan, Yunlin Peng, Liangliang Zhang, Xiangyu Wang, Jia Ge, Jianhui Jiang and   Ruqin Yu 
Anal. Methods, 2013,5, 2182-2187
DOI: 10.1039/C3AY40118A

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Recent Advances in Single-Liposome Characterization

Polly-Anna Ashford is a guest web writer for Analytical Methods. She is currently a PhD student at the University of East Anglia, UK.

Lipid bilayer structure of the liposome

Lipid bilayer structure of the liposome

The small size and lipid bilayer structure of liposomes make them an excellent carrier for use in drug delivery and gene therapy. Determining the chemical and physical properties of a liposome is key to evaluating its potential for different applications.

A range of techniques have been used to measure factors such as size, surface charge and encapsulation efficiency of these spherical structures. In this minireview, Xiaomei Yan and colleagues at Xiamen University, China, explore recent advances in techniques for single-liposome characterization. They evaluate the latest adaptations of traditional microscopy techniques and investigate the advantages and limitations of using flow cytometry for characterisation. Recently developed commercial techniques such as scanning ion occlusion sensing (SIOS) and nanoparticle tracking analysis (NTA) also offer more advanced methods of single-liposome analysis.

To access the full article, please click on the link below. This paper will be free to read until May 14th.

Analytical techniques for single-liposome characterization
Chaoxiang Chen, Shaobin Zhu, Tianxun Huang, Shuo Wanga and   Xiaomei Yan  
Anal. Methods, 2013,5, 2150-2157
DOI: 10.1039/C3AY40219C

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Top ten most accessed articles in February

This month sees the following articles in Analytical Methods that are in the top ten most accessed:-

Electrochemical impedance spectroscopy: an overview of bioanalytical applications
Edward P. Randviira and Craig E. Banks 
Anal. Methods, 2013,5, 1098-1115 
DOI: 10.1039/C3AY26476A  
     
Photocatalytic reduction of CO2: a brief review on product analysis and systematic methods 
Jindui Hong, Wei Zhang, Jia Rena and Rong Xu 
Anal. Methods, 2013,5, 1086-1097 
DOI: 10.1039/C2AY26270C   

Rhodamine and BODIPY chemodosimeters and chemosensors for the detection of Hg2+, based on fluorescence enhancement effects 
M. J. Culzoni, A. Muñoz de la Peña, A. Machuca, H. C. Goicoecheaa and R. Babiano 
Anal. Methods, 2013,5, 30-49 
DOI: 10.1039/C2AY25769F   

Sub-ppm quantification of Hg(ii) in aqueous media using both the naked eye and digital information from pictures of a colorimetric sensory polymer membrane taken with the digital camera of a conventional mobile phone 
Hamid El Kaoutit, Pedro Estévez, Félix C. García, Felipe Sernaa and José M. García 
Anal. Methods, 2013,5, 54-58 
DOI: 10.1039/C2AY26307F   

Application of an electronic tongue towards the analysis of brandies 
Xavier Cetó, Matias Llobet, Joan Marcob and Manel del Valle 
Anal. Methods, 2013,5, 1120-1129 
DOI: 10.1039/C2AY26066B   

Facile and sensitive paper-based chemiluminescence DNA biosensor using carbon dots dotted nanoporous gold signal amplification label 
Yanhu Wang, Shoumei Wang, Shenguang Ge, Shaowei Wang, Mei Yan, Dejin Zanga and Jinghua Yu 
Anal. Methods, 2013,5, 1328-1336 
DOI: 10.1039/C2AY26485D  

Colorimetric anticancer drug detection by gold nanoparticle-based DNA interstrand cross-linking 
Xiaoji Xie, Renren Deng, Feng Liu, Wei Xu, Sam Fong Yau Li and Xiaogang Liu 
Anal. Methods, 2013,5, 1116-1119 
DOI: 10.1039/C3AY26422J   

Non-invasive detection of biomechanical and biochemical responses of human lung cells to short time chemotherapy exposure using AFM and confocal Raman spectroscopy 
Lifu Xiao, Mingjie Tang, Qifei Lia and Anhong Zhou 
Anal. Methods, 2013,5, 874-879 
DOI: 10.1039/C2AY25951F  

Metal enhanced fluorescent biosensing assays for DNA through the coupling of silver nanoparticles 
Weibing Qiang, Hui Lia and Danke Xu 
Anal. Methods, 2013,5, 629-635 
DOI: 10.1039/C2AY26097B   

Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry 
Carlos A. Penno, Denis Arsenijevic, Thierry Da Cunha, Gerd A. Kullak-Ublick, Jean-Pierre Montanice and Alex Odermatt 
Anal. Methods, 2013,5, 1155-1164 
DOI: 10.1039/C3AY26520J  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analytical Methods? Then why not submit to us today or alternatively email us your suggestions.

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Webinar – The next generation of SEC/GPC analysis

Join Chemistry World and Waters for a free webcast on the next generation of SEC/GPC analysis

Tuesday, 30 April 2013, 4pm BST (11am EST)

Speakers:

Tanya Jenkins: Product Marketing Manager, Waters
Michael O’Leary: Principal Application Scientist, Waters


Join us for this free webinar in order to…
•    Identify the requirements for an advanced chromatographic system to meet the needs for determination of molecular weight distributions
•    Understand the benefits of a complete system approach to molecular weight characterization
•    See how the new paradigm in molecular size characterization will reduce test cycle time and consumption of operating chemicals while providing improved test precision with statistically enhanced data sets
•    See where the innovative separation approach can allow for a deeper understanding of polymeric properties and their variation

Register today at http://rsc.li/waters-acquity

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HPLC 2013 Symposium, Amsterdam, 16th-20th June 2013

The 39th International Symposium on High-Performance Liquid-Phase Separations and Related Techniques

Amsterdam RAI, June 16-20, 2013

Abstract deadline for poster presentations May 1, 2013

An international forum for scientific discussion of the methods of high performance liquid chromatography in its various forms, along with the complementary separation techniques such as electrophoresis, electro-chromatography, field-flow fractionation, supercritical fluid chromatography and hyphenated techniques, such as LC-MS and CZE-MS.

For more information visit the website.

HPLC2013 Amsterdam

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Square Wave Voltammetry: Recent Applications

Recent applications of square wave voltammetry

In this Critical Review, Aicheng Chen and Badal Shah describe the latest developments in electrochemical biosensing based on square wave voltammetry (SWV).

Because of its high sensitivity and selectivity, SWV has been widely used for detection of disease-related biomarkers, environmental pollutants and food contaminants. The authors define the recent biosensors based on SWV as the next generation point of care diagnostic devices, and highlight the successful applications of SWV in food analysis, environmental monitoring and enzymes kinetics.

To read the full article, please access the link below. This paper will be free to read until April 25th. Have a read!

Electrochemical sensing and biosensing based on square wave voltammetry
Aicheng Chen and Badal Shah
Anal. Methods, 2013, Advance Article
DOI: 10.1039/C3AY40155C

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A Gold-Antibody Nanocomposite for Detection of Tumour Markers

Polly-Anna Ashford is a guest web writer for Analytical Methods. She is currently a PhD student at the University of East Anglia, UK.

Synthesis of gold-antibody nanocomposite and AFP immunoassay

Synthesis of gold-antibody nanocomposite and AFP immunoassay

The construction of successful biosensors is often hampered by the difficulty of immobilising biomolecules onto the desired surface in an orderly fashion. As a support medium, nanoparticles display a particularly large surface-to-volume ratio and their physical properties can be adjusted to match requirements.

Researchers led by Zhihui Dai from the Nanjing Normal University, China, have used a liquid-liquid interface technique to immobilise Ab1 antibodies onto gold nanoparticles, characterising the material using energy dispersive spectroscopy (EDS).

Detection of abnormal levels of alpha-fetoprotein (AFP) can indicate the presence of cancerous cells. In this work, a sandwich immunoassay was used to test the sensitivity of the Au-Ab1 nanocomposite towards AFP, demonstrating good selectivity, stability and reproducibility of the sensor. In clinical samples, the gold-based sensor performed well against the current enzyme-linked immunosorbant assay (ELISA) method of testing.

Do you want to know more about this research? Click on the link below, this article will be free to read until April 19th:

Gold–antibody nanocomposite thin film fabricated by a liquid–liquid interface technique and its application for the sensitive immunoassay of alpha-fetoprotein
Kun Wang ,  Tianxiang Wei ,  Wenwen Tu ,  Min Han and Zhihui Dai
Anal. Methods, 2013,5, 1909-1914
DOI: 10.1039/C3AY26541B

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Analytical Methods Issue 8 now online!

Analytical Methods CoverThe latest issue of Analytical Methods is now available online. Take a look at our great new cover and read all about the innovative research behind it.

Stephen O’Driscoll and colleagues at the Dublin City University, Ireland, describe how we can use a simple mobile phone for environmental and diagnostic monitoring.

In their work featured in our outside front cover, they describe a phone’s camera which enables detection of fluorescence from a number of sensor spots on a disposable optical sensor chip without the need for communication with a remote server. The new method combines the functionality of the camera with the phone’s data processing and allows analysis of detected fluorescence intensity. According to the authors, mobile phones could represent an attractive technology platform for the development of portable sensors.   

A novel camera phone-based platform for quantitative fluorescence sensing
Stephen O’Driscoll ,  Brian D. MacCraith and Conor S. Burke
Anal. Methods, 2013,5, 1904-1908
DOI: 10.1039/C3AY40116B

Along with our new cover, here are some HOT articles for you to enjoy. Have a read now!

Gold–antibody nanocomposite thin film fabricated by a liquid–liquid interface technique and its application for the sensitive immunoassay of alpha-fetoprotein
Kun Wang ,  Tianxiang Wei ,  Wenwen Tu ,  Min Han and Zhihui Dai
Anal. Methods, 2013,5, 1909-1914
DOI: 10.1039/C3AY26541B

Protocol for production of matrix-matched brain tissue standards for imaging by laser ablation-inductively coupled plasma-mass spectrometry
Dominic J. Hare ,  Jessica Lear ,  David Bishop ,  Alison Beavis and Philip A. Doble
Anal. Methods, 2013,5, 1915-1921
DOI: 10.1039/C3AY26248K

Characterization of grape seed residues from the ethanol-distillation industry
Ángela Peralbo-Molina ,  Feliciano Priego-Capote and María Dolores Luque de Castro
Anal. Methods, 2013,5, 1922-1929
DOI: 10.1039/C3AY00008G

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