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SERS based magnetic immunoassay for cancer biomarker HE4

02 Sep 2015

Schematic diagram of magnetic immunoassay based on SERS

Women with gynaecological malignancies are at high risk of developing ovarian cancer (OC). OC does not show any symptoms in the early stages, resulting in a delay in detection and definite diagnosis is obtained in the later stages. At present, ultrasonic imaging and assay of biomarkers (e.g. Human epididymis protein 4, HE4 ) are used for the diagnosis of OC. But the ultrasonic imaging can not discriminate between benign and malignant tumours and the immunoassays are time consuming, require sophisticated equipment and skilled professionals. Therefore, there is an urgent need for the development of a sensitive method for trace assay of biomarkers such as HE4. Jianlin Yao and colleagues from the Soochow University have developed a new approach based on surface enhanced Raman spectroscopy (SERS) and a magnetic immunoassay technique for rapid detection and separation of HE4 with high sensitivity and selectivity. ‘ The immuno nanoparticles studied could be developed as reagent kits in the clinical diagnosis of cancer’, opines Jianlin Yao. To learn more about the study, read the full article for free* by following the link given below.

Ultra-sensitive magnetic immunoassay of HE4 based on surface enhanced Raman spectroscopy
Ming Ge, Chao Wei, Minmin Xu, Congwei Fang, Yaxian Yuan, Renao Gu and Jianlin Yao
Anal. Methods, 2015, 7, 6489-6495
DOI: 10.1039/C5AY00977D

About the webwriter

Sushil Benke is a graduate student under the supervision of Dr. H. N. Gopi in the Department of Chemistry at Indian Institute of Science Education and Research (IISER), Pune. His research focuses on the development of novel antimicrobial peptidomimetics.

*Access is free through a registered RSC account.

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HOT articles in Analytical Methods

20 Apr 2015

Take a look at our recent HOT Analytical Methods articles, these are now free to access for the next few weeks!

A novel exonuclease III-aided amplification assay based on graphene platform for sensitive detection of adenosine triphosphate
Changchun Wen, Yong Huang, Jianniao Tian, Kun Hu, Li Pan and Shulin Zhao
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C5AY00354G

Monitoring the Clandestine Synthesis of Methamphetamine in Real-Time with Ambient Sampling, Portable Mass Spectrometry
Adam E. O’Leary, Seth E. Hall, Kyle E. Vircks and Christopher C. Mulligan
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C5AY00511F
Graphical abstract
Analytical Chemistry Research at Primarily Undergraduate Institutions: Training Tomorrow’s Investigators
Michelle L. Kovarik
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C5AY00510H

Identification of metabolites of AHTN in rat urine and feces by liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Yi Yang, Yin Zhang, Jing Zhang and Bing Shao
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY03063J

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Hot articles in Analytical Methods

27 Mar 2015

Take a look at our recent HOT Analytical Methods articles, these are now free to access for the next few weeks!

Graphical Abstract

A fast and highly sensitive method for the detection of canine distemper virus by naked eye
Caroline R. Basso, Claudia C. Tozato, João Pessoa A. Junior and Valber A. Pedrosa
Anal. Methods, 2015, 7, 2264-2267
DOI: 10.1039/C4AY02644F

Simple one-step preconcentration and cleanup with micellar system for high performance liquid chromatography determination of pyrethroids in traditional Chinese medicine
Ligang Chen and Wenjuan Xing
Anal. Methods, 2015, 7, 1691-1700
DOI: 10.1039/C4AY02553A

Ammonium salting out extraction with analyte preconcentration for sub-part per billion quantitative analysis in surface, ground and drinking water by flow injection tandem mass spectrometry
Sergio C. Nanita, Laura G. Kaldon and David L. Bailey
Anal. Methods, 2015, 7, 2300-2312
DOI: 10.1039/C4AY02620A

A chronopotentiometric flow injection system for aptasensing of E. coli O157
Jiahong Lei, Jiawang Ding and Wei Qin
Anal. Methods, 2015, 7, 825-829
DOI: 10.1039/C4AY02662D

Combining a Portable, Tandem Mass Spectrometer with Automated Library Searching – An Important Step Towards Streamlined, On-Site Identification of Forensic Evidence
Adam E. O’Leary, Herbert Oberacher, Seth E. Hall and Christopher C. Mulligan
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02778G

Portable Diffuse Reflectance Infrared Fourier Transform (DRIFT) Technique for the Non-invasive Identification of Canvas Ground: IR Spectra Reference Collection
M. Manfredi, E. Barberis, A. Rava, E. Robotti, F. Gosetti and E. Marengo
Anal. Methods, 2015, 7, 2313-2322
DOI: 10.1039/C4AY02006E

Graphical Abstract The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries.
Adam Le Gresley, Emma Simpson, Alex J. Sinclair, Neil Williams, Gary R. Burnett, Dave J. Bradshaw and Robert A. Lucas
Anal. Methods, 2015, 7, 2323-2332
DOI: 10.1039/C4AY02681K

Amino Acid Composition of Human Scalp Hair as a Biometric Classifier and Investigative Lead
Ayat H. B. Rashaid, Peter B. Harrington and Glen P. Jackson
Anal. Methods, 2015, 7, 1707-1718
DOI: 10.1039/C4AY02588A

Rapid and sensitive detection of Salmonella typhimurium using aptamer conjugated carbon dots as fluorescence probe
Renjie Wang, Yi Xu, Tao Zhang and Yan Jiang
Anal. Methods, 2015, 7, 1701-1706
DOI: 10.1039/C4AY02880E

Rapid assay of neopterin and biopterin in urine by wooden-tip electrospray ionization mass spectrometry
Anal. Methods, 2015, 7, 2913-2916
DOI: 10.1039/C5AY00004A
Bi-cheng Yang, Fa-ying Liu, Jiu-bai Guo, Lei Wan, Juan Wu, Feng Wang, Huai Liu and Ou-ping Huang

Improved Monitoring of P. aeruginosa on Agar Plates
T. A. Webster, H. J. Sismaet, A. F. Sattler and E. D. Goluch
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02794A

Binding interaction between prazosin and a1A-adrenoceptor: Investigation on the thermodynamic behaviours and the binding mechanism by high performance affinity chromatography
Jing Wang, Qian Li, Lingjian Yang, Yajun Zhang, Jie Yu, Xinfeng Zhao, Jianbin Zheng, Youyi Zhang and Xiaohui Zheng
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY03046J

Characteristics Region Extraction of Time Series Three-dimensional Fluorescence Spectroscopy
Shaohui Yu, Xue Xiao, Nanjing Zhao and Jisheng Yang
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02984D

Analysis of fatty acids and triacylglycerides by Pd nanoparticle-assisted laser desorption/ionization mass spectrometry
Yuliya E. Silina, Claudia Fink-Straube, Heiko Hayen and Dietrich A. Volmer
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C5AY00705D

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HOT articles in Analytical Methods

11 Dec 2014

Take a look at our recent HOT Analytical Methods articles, these are now free to access for the next few weeks!

Simultaneous separation and sensitive detection of four ß2-agonists in biological specimen by CE-UV with field-enhanced sample injection method
Cheng Chen, Lingchen Meng, Meixian Li and Zhiwei Zhu
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02385D

Microwave-assisted synthesis of resveratrol imprinted polymers with enhanced selectivity
Lachlan J. Schwarz, Mahesh K. Potdar, Basil Danylec, Reinhard I. Boysen and Milton T. W. Hearn
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02518K

Graphical Abstract

High throughput analysis of four Sudan dyes using direct analysis in real time-mass spectrometry
Ze Li, Yi-Wei Zhang, Yi-Ding Zhang, Yu Bai and Hu-Wei Liu
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02409E

Structural dependency of collagen fibers on ion types revealed by in situ second harmonic generation (SHG) imaging method
Xuye Lang and Julia G. Lyubovitsky
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02242D

Development and Validation of a Quantitative Method for Determination of Retigabine and its N-Acetyl Metabolite; Overcoming Challenges Associated with Circulating Labile N-Glucuronide Metabolites
Hermes Licea Perez, Sharon L. Boram and Christopher A. Evans
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02599G

HYPHENATION OF SINGLE-DROP MICROEXTRACTION WITH LASER-INDUCED BREAKDOWN SPECTROMETRY FOR TRACE ANALYSIS IN LIQUID SAMPLES: A VIABILITY STUDY
M. A. Aguirre, H. Nikolova, M. Hidalgo and A. Canals
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02218A

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HOT articles in Analytical Methods

01 Dec 2014

Take a look at our recent HOT Analytical Methods articles, these are now free to access for the next few weeks!

Screening and Structural Characterization of Potential a-Glucosidase Inhibitors from Radix Astragali Flavonoids Extract by Ultrafiltration LC-DAD-ESI-MSn
Wenyue Jiang, Hong Kan, Pengdong Li, Shu Liu and Zhongying Liu
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02081B
Graphical Abstract
Surface Plasmon Resonance Imaging (SPRi) for Multiplexed Evaluation of Bacterial Adhesion onto Surface Coatings
Pegah N. Abadian and Edgar D. Goluch
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02094D

A rapid DNA lateral flow test for the detection of transgenic maize by isothermal amplification of the 35S promoter
Claudia Kolm, Robert L. Mach, Rudolf Krska and Kurt Brunner
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY01997K

Double carboxyl silicane modified graphene oxide coated silica composite as sorbent for solid-phase extraction of quarternary alkaloids
Houmei Liu, Yong Guo, Xusheng Wang, Yikun Li, Xiaojing Liang and Xia Liu
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02172J

Proteomic identification of organic additives in the mortars of ancient Chinese wooden buildings
Huiyun Rao, Bo Li, Yimin Yang, Qinglin Ma and Changsui Wang
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY01766H

Chromatographic characteristics of water-soluble vitamins with irradiation processing and its application
Ying Li, Changyin Lv, Qiang Sun, Ying Zhao and Yunjing Li
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY01312C
Graphical Abstract
A new colorimetric protocol for selective detection of phosphate based on the inhibition of peroxidase-like activity of magnetite nanoparticles
Chuanxia Chen, Lixia Lu, Yu Zheng, Dan Zhao, Fan Yang and Xiurong Yang
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02461C

Sequential Detection of Fe3+ and As3+ Ions by Naked Eye through Aggregation and Dis-Aggregation of Biogenic Gold Nanoparticles
Somasundaram Kaviya and Edamana Prasad
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02342K

Synthesis and evaluation of a silica-bonded concanavalin A material for lectin affinity enrichment of N-linked glycoproteins and glycopeptides
Yujie Liu, Dongmei Fu, Yuansheng Xiao, Zhimou Guo, Long Yu and Xinmiao Liang
Anal. Methods, 2015, Advance Article
DOI: 10.1039/C4AY02286F

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HOT articles in Analytical Methods

03 Nov 2014

Take a look at our recent HOT Analytical Methods articles, these are now free to access for the next few weeks!

Historical textile dyeing with Genista tinctoria L.: a comprehensive study by UPLC-MS/MS analysis
Lore G. Troalen,Ashley S. Phillips, David A. Peggie, Perdita E. Barranac and Alison N. Hulme
Anal. Methods, 2014, 6, 8915-8923
DOI: 10.1039/C4AY01509F

Separation of Carbon Quantum Dots on a C18 Column by a binary gradient elution via HPLC
Yan Lu,Jun Wang,Hongyan Yuanb and Dan Xiao
Anal. Methods, 2014, 6, 8124-8128
DOI: 10.1039/C4AY01052C

Graphical Abstract

Simultaneous Colorimetric Detection of Improvised Explosive Compounds using Microfluidic Paper-Based Analytical Devices
Kelley L. Peters,Inge Corbin,Lindsay M. Kaufman,Kyle Zreibe,Lucas Blanesb and Bruce R. McCord
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01677G

Microfluidic Devices for Label-Free and Non-Instrumented Quantitation of Unamplified Nucleic Acids by Flow Distance Measurement
Debolina Chatterjee, Danielle S. Mansfielda and Adam T. Woolley
Anal. Methods, 2014, 6, 8173-8179
DOI: 10.1039/C4AY01845A

The development of an autonomous sensing platform for the monitoring of ammonia in water using a simplified Berthelot method
Deirdre Cogan,John Cleary,Cormac Fay,Aoife Rickard,Kamil Jankowski,Thomas Phelan, Mark Bowkettb and Dermot Diamonda
Anal. Methods, 2014, 6, 7606-7614
DOI: 10.1039/C4AY01359J

Fatty acid profile reveals toxic response in adipose tissue of C57BL/6J mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Chuanqin Hu,Shuhai Lina and Zongwei Cai
Anal. Methods, 2014, 6, 8207-8211
DOI: 10.1039/C4AY01479K

Graphical Abstract

Direct determination of niobium at the low nanogram level in mineral waters and freshwaters
Montserrat Filella,David-Julien Magnenatb and Michaël Bensimonb
Anal. Methods, 2014, 6, 8090-8093
DOI: 10.1039/C4AY01860E

Paper-based electrochemical immunoassay for rapid, inexpensive cancer biomarker protein detection
C.K.Tang, A.Vazea and J.F.Rusling
Anal. Methods, 2014, 6, 8878-8881
DOI: 10.1039/C4AY01962H

Radioisotope-based XRF instrumentation for determination of lead in paint: an assessment of the current accuracy and reliability of portable analyzers used in New York State
Diana Guimarães,Tracie M. Cleaver,Steven F. Martin and Patrick J. Parsons
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00819G

Development of combined salt and air assisted liquid-liquid microextraction as a novel sample preparation technique
Rouhollah Heydari and Sanaz Zarabi
Anal. Methods, 2014, 6, 8469-8475
DOI: 10.1039/C4AY01723D

Separation of Asparagine, Valine and Tetraethylammonium ions Overlapping in an Ion Mobility Spectrometer by clustering with Methanol introduced as a Modifier in the Buffer Gas
R. Fernandez-Maestre,C. Wu and H. H. Hill, Jr
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01814A

Graphical Abstract

Development of a sensitive and specific enzyme-linked immunosorbent assay for the determination of fludioxonil residues in fruit juices
Josep V. Mercader,Antonio Abad-Fuentes, Consuelo Agulló, Antonio Abad-Somovill and Francesc A. Esteve-Turrillas
Anal. Methods, 2014, 6, 8924-8929
DOI: 10.1039/C4AY01756K

Induction of formation and conformational conversion of DNA G-quadruplex by fangchinoline
Wei Tan, Han Chen, Jiang Zhou, Ming Xub and Gu Yuan
Anal. Methods, 2014, 6, 8476-8481
DOI: 10.1039/C4AY01881H

Application of online microdialysis coupled with liquid chromatography–tandem mass spectrometry method in assessing neuroprotective effect of Coptidis Rhizoma on diabetic rats
Qianqian Wang, Jing Zhang, Zifeng Pi, Zhong Zheng, Junpeng Xing, Fengrui Song, Shu Liu and Zhiqiang Liu
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01809E

Highly Sensitive and Portable Mercury (II) Ions Sensor by Using Personal Glucose Meter
Xu Xue-tao, Liang Kai-yi and Zeng Jia-ying
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01502A

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Recent HOT articles in Analytical Methods

13 Aug 2014

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read for the next few weeks. We hope you enjoy reading them!

Chemical analysis of the Tibetan herbal medicine Carduus acanthoides by UPLC/DAD/qTOF-MS and simultaneous determination of nine major compounds
Ru Li, Sui-ku Liu, Wei Song, Yuan Wang, Yan-jiao Li, Xue Qiao, Hong Liang and Min Ye
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01138D, Paper

In situ characterization by Raman and X-ray fluorescence spectroscopy of post-Paleolithic blackish pictographs exposed to the open air in Los Chaparros shelter (Albalate del Arzobispo, Teruel, Spain)
Àfrica Pitarch, Juan Francisco Ruiz, Silvia Fdez-Ortiz de Vallejuelo, Antonio Hernanz, Maite Maguregui and Juan Manuel Madariaga
Anal. Methods, 2014,6, 6641-6650
DOI: 10.1039/C4AY00539B, Paper

Detection of residual biocides in antibody drug conjugates for ImmunoPET imaging
Colin D. Medley, Jason Gruenhagen, Peter Yehl and Nik P. Chetwyn
Anal. Methods, 2014,6, 6635-6640
DOI: 10.1039/C4AY01418A, Paper

Electrophysiological analysis of biopsy samples using elasticity as an inherent cell marker for cancer detection
Azhar Ilyas, Waseem Asghar, Shahina Ahmed, Yair Lotan, Jer-Tsong Hsieh, Young-tae Kim and Samir M. Iqbal
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00781F, Paper

Microchip nonaqueous capillary electrophoresis of saturated fatty acids using a new fluorescent dye
M. L. Cable, A. M. Stockton, M. F. Mora, K. P. Hand and P. A. Willis
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01243G, Communication

Mobile Water Kit (MWK): a smartphone compatible low-cost water monitoring system for rapid detection of total coliform and E. coli
Naga Siva Kumar Gunda, Selvaraj Naicker, Sujit Shinde, Sanjay Kimbahune, Sandhya Shrivastava and Sushanta Mitra
Anal. Methods, 2014,6, 6236-6246
DOI: 10.1039/C4AY01245C, Paper

Cotton fabric as an immobilization matrix for low-cost and quick colorimetric enzyme-linked immunosorbent assay (ELISA)
Saeedeh Bagherbaigi, Emma P. Córcoles and Dedy H. B. Wicaksono
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01071J, Paper

A new screening method for recombinant Saccharomyces cerevisiae strains based on their xylose fermentation ability measured by near infrared spectroscopy
Hiroyuki Morita, Tomohisa Hasunuma, Maria Vassileva, Akihiko Kondo and Roumiana Tsenkova
Anal. Methods, 2014,6, 6628-6634
DOI: 10.1039/C4AY00785A, Paper

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Recent HOT articles in Analytical Methods

16 Jul 2014

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read for the next few weeks. We hope you enjoy reading them!

Handheld and non-destructive methodologies for the compositional investigation of meteorite fragments
Vincenza Crupi, Alessandra Giunta, Barry Kellett, Francesca Longo, Giacomo Maisano, Domenico Majolino, Antonella Scherillo and Valentina Venuti
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00253A

Electrochemical detection of pathogenic bacteria by using a glucose dehydrogenase fused zinc finger protein
Jinhee Lee, Atsuro Tatsumi, Koichi Abe, Wataru Yoshida, Koji Sode and Kazunori Ikebukuro
Anal. Methods, 2014,6, 4991-4994
DOI: 10.1039/C4AY00977K

A signal on aptamer-based electrochemical sensing platform using a triple-helix molecular switch
Yudan Du, Yinfei Mao, Xiaoxiao He, Kemin Wang, Genping Yan, Jinquan Liu and Yonghong Wang
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00807C

Determination of spatial and temporal variability of pH and dissolved oxygen concentrations in a seasonally hypoxic semi-enclosed marine basin using continuous monitoring
Timothy Sullivan, Ciara Byrne, Luke Harman, John Davenport, Rob McAllen and Fiona Regan
Anal. Methods, 2014,6, 5489-5497
DOI: 10.1039/C3AY42162G

Electromembrane extraction followed by high performance liquid chromatography: an efficient method for extraction and determination of morphine, oxymorphone, and methylmorphine from urine samples
Yadollah Yamini, Ali Pourali, Shahram Seidi and Maryam Rezazadeh
Anal. Methods, 2014,6, 5554-5565
DOI: 10.1039/C4AY00480A

Determination of parabens in human urine by liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Shaoyou Lu, Shihan Gong, Shengtao Ma, Xiangying Zeng, Zhiqiang Yu, Guoying Sheng and Jiamo Fu
Anal. Methods, 2014,6, 5566-5572
DOI: 10.1039/C3AY42063A

Amplified detection of bleomycin based on an electrochemically driven recycling strategy
Shan Lu, Mei Yang, Xiaoxi Li, Xinjian Liu, Yongmei Yin and Ya Cao
Anal. Methods, 2014,6, 5573-5577
DOI: 10.1039/C4AY00989D

Preconcentration and determination of chromium species by cloud point extraction-flame atomic absorption spectrometry
Limin Zhang, Xuelei Li, Xiaoyan Wang, Wentao Wang, Xiangshu Wang and Huayun Han
Anal. Methods, 2014,6, 5578-5583
DOI: 10.1039/C4AY00922C

A review of sample preparation methods for quantitation of small-molecule analytes in brain tissue by liquid chromatography tandem mass spectrometry (LC-MS/MS)
Pei Li and Michael G. Bartlett
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00915K

Detection of Escherichia coli in potable water using personal glucose meters
Ravi Chavali, Naga Siva Kumar Gunda, Selvaraj Naicker and Sushanta K. Mitra
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01249F

A new screening method for recombinant Saccharomyces cerevisiae strains based on their xylose fermentation ability measured by near infrared spectroscopy
Hiroyuki Morita, Tomohisa Hasunuma, Maria Vassileva, Akihiko Kondo and Roumiana Tsenkova
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00785A

Kernel k-nearest neighbor classifier based on decision tree ensemble for SAR modeling analysis
Xin Huang, Qing-Song Xu, Dong-Sheng Cao, Yi-Ping Luo and Yi-Zeng Liang
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00836G

Cotton fabric as an immobilization matrix for low-cost and quick colorimetric enzyme-linked immunosorbent assay (ELISA)
Saeedeh Bagherbaigi, Emma P. Córcoles and Dedy H. B. Wicaksono
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY01071J

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Forbidden Fruit Now Edible: New Mass Spectrometry Approach for Food Pesticide Detection

09 Jun 2014

To ensure high crop yield, the addition of pesticides to crops may seem like a necessary evil. However, most applied chemicals have adverse side-effects to our health. Consequently, simple, effective, and accurate methods of pesticide detection is critical for safe food consumption. Unfortunately, most direct methods of pesticide detection that do not require sample preparation can only provide qualitative results. Furthermore, methods that are capable of quantitative analysis require complicated, time-consuming procedures of sample preparation prior to analysis. Anastasia Albert from the University of Muenster, Carsten Engelhard from the University of Siegen and other colleagues from Germany have evaluated ambient desorption/ionization high-resolution mass spectrometry (ADI-HR-MS) for quantitative pesticide detection in fruit, and have devised a streamlined procedure for effective analysis. Find out more about their discovery by accessing the link below:

ADI-HR Mass Spectrometry for Pesticide Detection in Fruit

Rapid and quantitative analysis of pesticides in fruits by QuEChERS pretreatment and low-temperature plasma desorption/ionization orbitrap mass spectrometry

Anastasia Albert, Andrea Kramer, Simon Scheeren and Carsten Engelhard

Anal. Methods, 2014, Advance Article

DOI: 10.1039/C4AY00103F

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HOT articles in Analytical Methods

29 May 2014

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read for the next few weeks. Enjoy the reading!

Determination of boron in silicon without use of additional complexing agents
Matthias Balski, Franziska Emmerling, Heinrich Kipphardt and Ulrich Panne
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00410H, Paper

Rapid and quantitative analysis of pesticides in fruits by QuEChERS pretreatment and low-temperature plasma desorption/ionization orbitrap mass spectrometry
Anastasia Albert, Andrea Kramer, Simon Scheeren and Carsten Engelhard
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00103F, Paper

Time-gated fluorescence sensor for silver ions using Mn:CdS/ZnS quantum dots/DNA/gold nanoparticle complexes
Xiaoyan Leng, Dawei Huang, Chenggang Niu, Xiaoyu Wang, Guangming Zeng and Qiuya Niu
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42129E, Paper

Rapid measurement of total polyphenols content in cocoa beans by data fusion of NIR spectroscopy and electronic tongue
Xingyi Huang, Ernest Teye, Livingstone K. Sam-Amoah, Fangkai Han, Liya Yao and William Tchabo
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00223G, Paper

Protein/peptide purification by three-well OFFGEL electrophoresis with immobilized ultra narrow pH gradient gels
Elena Tobolkina, Fernando Cortés-Salazar, Liang Qiao and Hubert H. Girault
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00088A, Paper

A formaldehyde trace gas sensor based on a thermoelectrically cooled CW-DFB quantum cascade laser
Jingsong Li, Uwe Parchatka and Horst Fischer
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41964A, Paper

New insights on blue pigments used in 15th century paintings by synchrotron radiation-based micro-FTIR and XRD
Nati Salvadó, Salvador Butí, Miguel A. G. Aranda and Trinitat Pradell
Anal. Methods, 2014,6, 3610-3621
DOI: 10.1039/C4AY00424H, Paper

Real-time detection of chemical warfare agent simulants in forensic samples using active capillary plasma ionization with benchtop and field-deployable mass spectrometers
Morphy Dumlao, Pablo Martinez-Lozano Sinues, Maryia Nudnova and Renato Zenobi
Anal. Methods, 2014,6, 3604-3609
DOI: 10.1039/C4AY00303A, Paper

Determination of iodinated X-ray contrast agents in pharmaceutical formulations and artificial urine samples by differential pulse voltammetry
Piotr Markowski, Katarzyna Piwowar and Irena Baranowska
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00538D, Paper

Amplified fluorescence sensing of miRNA by combination of graphene oxide with duplex-specific nuclease
Shuang Guo, Fan Yang, Yulin Zhang, Yong Ning, Qunfeng Yao and Guo-Jun Zhang
Anal. Methods, 2014,6, 3598-3603
DOI: 10.1039/C4AY00345D, Paper

Which spectroscopic technique allows the best differentiation of coffee varieties: comparing principal component analysis using data derived from CD-, NMR- and IR-spectroscopies and LC-MS in the analysis of the chlorogenic acid fraction in green coffee beans
Sagar Deshpande, Rasha M. El-Abassy, Rakesh Jaiswal, Pinkie Eravuchira, Bernd von der Kammer, Arnulf Materny and Nikolai Kuhnert
Anal. Methods, 2014,6, 3268-3276
DOI: 10.1039/C3AY41970C, Paper

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Archive for the ‘Hot Article’ Category

SERS based magnetic immunoassay for cancer biomarker HE4

HOT articles in Analytical Methods

Hot articles in Analytical Methods

HOT articles in Analytical Methods

HOT articles in Analytical Methods

HOT articles in Analytical Methods

Recent HOT articles in Analytical Methods

Recent HOT articles in Analytical Methods

Forbidden Fruit Now Edible: New Mass Spectrometry Approach for Food Pesticide Detection

HOT articles in Analytical Methods

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