SERS based magnetic immunoassay for cancer biomarker HE4

Schematic diagram of magnetic immunoassay based on SERS

Women with gynaecological malignancies are at high risk of developing ovarian cancer (OC). OC does not show any symptoms in the early stages, resulting in a delay in detection and definite diagnosis is obtained in the later stages. At present, ultrasonic imaging and assay of biomarkers (e.g. Human epididymis protein 4, HE4 ) are used for the diagnosis of OC. But the ultrasonic imaging can not discriminate between benign and malignant tumours and the immunoassays are time consuming, require sophisticated equipment and skilled professionals. Therefore, there is an urgent need for the development of a sensitive method for trace assay of biomarkers such as HE4. Jianlin Yao and colleagues from the Soochow University have developed a new approach based on surface enhanced Raman spectroscopy (SERS) and a magnetic immunoassay technique for rapid detection and separation of HE4 with high sensitivity and selectivity. ‘ The immuno nanoparticles studied could be developed as reagent kits in the clinical diagnosis of cancer’, opines Jianlin Yao. To learn more about the study, read the full article for free* by following the link given below.

Ultra-sensitive magnetic immunoassay of HE4 based on surface enhanced Raman spectroscopy
Ming Ge, Chao Wei, Minmin Xu, Congwei Fang, Yaxian Yuan, Renao Gu and Jianlin Yao
Anal. Methods, 2015, 7, 6489-6495
DOI: 10.1039/C5AY00977D

About the webwriter
Sushil Benke is a graduate student under the supervision of Dr. H. N. Gopi in the Department of Chemistry at Indian Institute of Science Education and Research (IISER), Pune. His research focuses on the development of novel antimicrobial peptidomimetics.

*Access is free through a registered RSC account.

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