Paull et al., Anal. Methods, 2012, Advance Article
This month we have a HOT article from Brett Paull, the Editor in Chief of Analytical Methods. Sialic acids have many biological roles. The importance of sialic acids to a glycoprotein’s half-life means that there is a strong need to determine the sialic acid content of a glycoprotein when examining its function and activity as a potential therapeutic. A team from Ireland and Australia, have developed a very rapid and analytically robust method that can quantitatively determine total free sialic acid, based upon monolithic reversed-phase chromatography. This method has been developed and specifically applied to process a range of very complex samples from the biopharmaceutical industry. This article will be free to read for 2 weeks.
Rapid and sensitive chromatographic determination of free sialic acid in complex bio-pharma fermentation media samples
Hassan Alwael, Damian Connolly and Brett Paull
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25299F
