Following the recent highlight of topical reviews in OBC, here is our latest ‘Hot Perspective’:
- read about the most advanced developments on Trichlorosilane mediated asymmetric reductions of the C=N bond in this review article by Simon Jones and Christopher J. A. Warner.
Concise but thorough, the review will take you through efficient and economical ways to access chiral amines via the trichlorosilane mediated organocatalytic reduction of ketimines, and provide a direct quantitative comparison to transition-metal mediated process.
Trichlorosilane mediated asymmetric reductions of the C=N bond
Simon Jones and Christopher J. A. Warner
Org. Biomol. Chem., 2012, 10, 2189-2200
DOI: 10.1039/C2OB06854K, Perspective
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