Coupling of unactivated aldehydes and Anticancer activity of oleanolic acid derivatives on the cover of OBC issue 11

Welcome to OBC issue 11, 2012 

Oscar Navarro and colleagues at the University of Hawaii at Manoa have used well-defined (N-heterocyclic carbene)–Ag(I) complexes for the A3 reaction, thereby allowing for the coupling of unactivated aldehydes at room temperature with very short reaction times. This work is featured on OBC‘s outside front cover, showcasing a scheme of the reaction depicted in their article over a picture of the coast of Lanikai, in Hawaii.

Well-defined (N-heterocyclic carbene)–Ag(I) complexes as catalysts for A3 reactions
Ming-Tsz Chen, Brant Landers and Oscar Navarro 
DOI: 10.1039/C2OB06900H 

The inside front cover illustrates work by Barbara Bednarczyk–Cwynar et al. at Poznan University of Medical Sciences, Poland, who highlight the strong cytotoxic activity on KB, MCF-7 and HeLa cell lines of novel A-ring or/and C-ring modified methyl oleanolate derivatives.

Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines
Barbara Bednarczyk–Cwynar, Lucjusz Zaprutko, Piotr Ruszkowski and Bogusław Hładoń
DOI: 10.1039/C2OB06923G

Interested? Why not read both communications, they are FREE to access for the next 6 weeks.

 

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