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International Chemical Biology Society (ICBS) – 5th Annual Conference

29 Sep 2016

Organic & Biomolecular Chemistry (OBC) is pleased to support the 2016 annual meeting of the International Chemical Biology Society. The conference aims to provide a forum for chemical biologists to speak of their work and discuss important scientific problems and to promote exchange between emerging and established scientists.

This international conference has a balanced program of speakers from all disciplines in chemical biology ranging from infectious diseases to natural products to epigenetics and many more. This year the speakers include:

Laura Kiessling (University of Wisconsin-Madison) – Us Versus Them: Microbial Glycans as Cellular ID Cards
Kai Johnsson (École PolytechniqueFédérale de Lausanne) – Expanding Protein Function Through Synthetic Chemistry
Junying Yuan (Harvard Medical School) – Regulation of Inflammation and Cell Death by RIPK1
Ulrike Eggert (Molecular BioSystems Editorial Board, King’s College London) – A Chemical Approach to Understanding Cell Division
Tapas Kundu (Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore) – Small Molecule Modulators of Histone Acetyltransferases: Implications in Disease Biology
Emily Balskus (Harvard University) – Chemical Discovery in the Human Microbiota

… and many more. For more information and to register please visit the website .

Meet the team:

James Anson (Deputy Editor of OBC, Natural Product Reports, MedChemComm and Molecular BioSystems) will be attending the event. He would love to hear about your research and meet with our readers, authors and referees. Please do get in touch with James if you would like to arrange a meeting in advance.

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Directing Biosynthesis V

22 Aug 2016

Don’t miss the fifth edition of this highly successful international natural products and chemical biology conference at the University of Warwick. Keynote speakers include Wilfred van der Donk, Janet Smith, John Verderas, Joern Piel and many more.

Oral abstract submission is now open!

Closing date 9 October 2016: submit abstracts online here.

This conference will cover aspects of natural product synthesis and development with emphasis on…

Biosynthesis of cell walls – targets for antimicrobials
Pathway engineering
Enzymology and structural biology
Natural products discovery – a response to AMR
Chemical ecology

Posters and exhibitors also welcome. Contact events@rsc.org for more information.

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Balticum Organicum Syntheticum (BOS) conference 2016

27 Apr 2016

Balticum Organicum Syntheticum (BOS) conference 2016

3^rd – 6^th July 2016, Riga, Latvia

Organic & Biomolecular Chemistry and Natural Product Reports are pleased to support the 2016 BOS conference. The conference aims to provide a forum for organic synthetic chemists to speak of their work and discuss important scientific problems and to promote discussion between academic and industrial scientists about the possibilities of mutual cooperation.

This international conference has a balanced program of academic and industrial speakers presenting fundamental and practical aspects of organic synthesis. This year the speakers include:

Emily Balskus (Harvard University, USA) Chemical Discovery in the Microbial World
Inga Cikotiené (Vilnius University, Lithuania) From Curiosity to Development of New Synthetic Methods
Nuno Maulide (University of Vienna, Austria) Catalytic Rearrangements: Inspiration for Methods and Total Synthesis
Per-Ola Norrby (AstraZeneca, Sweden) Predictive Chemistry: Virtual Screening in Asymmetric Catalysis
Virgil Percec (University of Pennsylvania, USA) A Materials Genome Approach to Mimics of Biological Membranes and their Programmable Glycan Ligands
Stefan Schunk (Grünenthal GmbH, Germany) Cebranopadol, A Novel Analgesic – It’s Discovery from the MedChem Perspective
Ryan Shenvi (The Scripps Research Institute) Chemical Synthesis of Secondary Metabolites
John Sutherland (MRC Laboratory of Molecular Biology, Cambridge UK) Origins of Life Systems Chemistry
Māris Turks (Riga Technical University, Latvia) Sulfer Dioxide: Useful Reagent and Solvent in Organic Chemistry

For more information and to register please visit the website.

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RSC Organic Division Poster Symposium 2015

25 Sep 2015

RSC Organic Division Poster Symposium 2015, headline sponsored by F. Hoffmann-La Roche, Ltd.

Abstract submission is now open.

This poster symposium for final year organic chemistry PhD students will take place at The Royal Society of Chemistry at Burlington House, in London, Monday 30 November 2015.

The closing date for submissions is Wednesday 30 September 2015.
Get more information or submit an abstract now.

This symposium offers final year PhD students a chance to showcase their research to their peers, leading academics and industrial chemists. It is open to all branches of organic chemistry – in its broadest interpretation – and has a tradition of being the most competitive and highly-regarded organic chemistry symposium for PhD students in the UK and Ireland.

There will be a first prize of £500, two runner-up prizes of £250, and a ‘selected by Industry’ prize – also of £500. Industrial delegates will select this winner based on the potential for application in an industrial context.

We would like to thank F. Hoffmann-La Roche, Ltd. and our industry sponsors for their generous support of this event.

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Celebrating Ian Paterson’s 60th Birthday

30 Apr 2014

In May 2014, Ian Paterson celebrates his sixtieth birthday. Eighty students have completed PhDs under his guidance. To mark this milestone, the RSC are collating the papers he has published in RSC journals and making them available to everybody. Ian was born in Dundee, and studied at St Andrew’s University. Two papers were published in the Journal of the Chemical Society as a result of his undergraduate research. He then moved to the University of Cambridge to work with Ian Fleming and to contribute further to RSC publications. A postdoctoral fellowship at Columbia University followed, working with Gilbert Stork, who had published fewer papers with the RSC than Ian. Ian then returned to the UK, first to UCL and then to Cambridge, where he has been for the last three decades.He has developed new methods for stereoselective transformations, particularly the boron-mediated aldol reaction, and used these in the syntheses of larger and larger molecules with increasing stereochemical complexity. The first report of his approach to discodermolide appeared in Chem Comm (1993) and, in due course, the synthesis was scaled up so that it could be used for clinical development. Studies on spongistatin, spirastrellolide, dictyostatin and other complex natural products have all been reported in RSC journals, as well as investigations of hybrids and semi-synthetic analogues. Ian has been elected to fellowships both of the Royal Society and the Royal Society of Edinburgh, and has won many RSC prizes including the Meldola Prize (1983), Hickinbottom Fellowship (1989), Bader Award (1996), Synthetic Organic Chemistry Award (2001), and the Tilden Prize (2009).Professor Jonathan Goodman
University of Cambridge, UK

All articles are free to access until 13th June 2014

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim and Philip Maltas
Org. Biomol. Chem., 2012,10, 5873-5886, DOI: 10.1039/C2OB25101A

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas, Olivier Loiseleur, Julien Genovino and Christian Moessner
Org. Biomol. Chem., 2012,10, 5861-5872, DOI: 10.1039/C2OB25100K

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues
A. Jonathan Singh, Mina Razzak, Paul Teesdale-Spittle, Thomas N. Gaitanos, Anja Wilmes, Ian Paterson, Jonathan M. Goodman, John H. Miller and Peter T. Northcote
Org. Biomol. Chem., 2011,9, 4456-4466, DOI: 10.1039/C0OB01127D

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
Ian Paterson, Guy J. Naylor, Takeshi Fujita, Esther Guzmán and Amy E. Wright
Chem. Commun., 2010,46, 261-263, DOI: 10.1039/B921237J

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Synthesis and stereochemical determination of the spirastrellolides
Ian Paterson and Stephen M. Dalby
Nat. Prod. Rep., 2009,26, 865-873, DOI: 10.1039/B906991G

Synthesis and stereochemical determination of the spirastrellolides

Total synthesis of (-)-spirangien A and its methylester
Ian Paterson, Alison D. Findlay and Christian Noti
Chem. Commun., 2008, 6408-6410, DOI: 10.1039/B816229H

Total synthesis of the marine macrolide (+)-neopeltolide
Ian Paterson and Natalie A. Miller
Chem. Commun., 2008, 4708-4710, DOI: 10.1039/B812914B

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide
Ian Paterson, Guy J. Naylor and Amy E. Wright
Chem. Commun., 2008, 4628-4630, DOI: 10.1039/B811575C

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
Gordon J. Florence, Nicola M. Gardner and Ian Paterson
Nat. Prod. Rep., 2008,25, 342-375, DOI: 10.1039/B705661N

Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Julien Genovino, Jong Ho Lim and Christian Moessner
Chem. Commun., 2007, 1852-1854, DOI: 10.1039/B700827A

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
Ian Paterson and Nicola M. Gardner
Chem. Commun., 2007, 49-51, DOI: 10.1039/B615122A

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas and Christian Moessner
Chem. Commun., 2006, 4186-4188, DOI: 10.1039/B612697A

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support
Ian Paterson, Dirk Gottschling and Dirk Menche
Chem. Commun., 2005, 3568-3570, DOI: 10.1039/B505746A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Karl R. Gibson and Debra J. Wallace
Org. Biomol. Chem., 2005,3, 2410-2419, DOI: 10.1039/B504148A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Renata M. Oballa, Debra J. Wallace and Roger D. Norcross
Org. Biomol. Chem., 2005,3, 2399-2409, DOI: 10.1039/B504146E

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Ian Paterson, David Y.-K. Chen, Mark J. Coster, José L. Aceña, Jordi Bach and Debra J. Wallace
Org. Biomol. Chem., 2005,3, 2431-2440, DOI: 10.1039/B504151A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, José L. Aceña, Jordi Bach, Linda E. Keown and Thomas Trieselmann
Org. Biomol. Chem., 2005,3, 2420-2430, DOI: 10.1039/B504149J

Phorboxazole B synthetic studies: construction of C(1–32) and C(33–46) subtargets
Ian Paterson, Alan Steven and Chris A. Luckhurst
Org. Biomol. Chem., 2004,2, 3026-3038, DOI: 10.1039/B407240E

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Ian Paterson, Robert Britton, Oscar Delgado and Amy E. Wright
Chem. Commun., 2004, 632-633, DOI: 10.1039/B316390C

Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation
Ian Paterson, Jose L. Aceña, Jordi Bach, David Y.-K. Chen and Mark J. Coster
Chem. Commun., 2003, 462-463, DOI: 10.1039/B212651F

Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S )-1-(benzyloxy)-2-methylpentan-3-one, and conformational aspects of extended polypropionates
Ian Paterson and Jeremy P. Scott
J. Chem. Soc., Perkin Trans. 1, 1999, 1003-1014, DOI: 10.1039/A809818B

Recent developments in asymmetric aldol methodology
Alison S. Franklin and Ian Paterson
Contemp. Org. Synth., 1994,1, 317-338, DOI: 10.1039/CO9940100317

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8d-lactone subunit
Ian Paterson and Stephen P. Wren
J. Chem. Soc., Chem. Commun., 1993, 1790-1792, DOI: 10.1039/C39930001790

The formation of allyl sulphides by phenylthio-migration: control by silicon
Ian Fleming, Ian Paterson and Andrew Pearce
J. Chem. Soc., Perkin Trans. 1, 1981, 256-262, DOI: 10.1039/P19810000256

Free radical addition to olefins. Part 23. Kinetics of the addition of chloroiodomethane to ethylene and vinyl fluoride
Ian Paterson, John M. Tedder and John C. Walton
J. Chem. Soc., Perkin Trans. 2, 1978, 884-887, DOI: 10.1039/P29780000884

Homosolvolysis
Hamish Low, Ian Paterson, John M. Tedder and John Walton
J. Chem. Soc., Chem. Commun., 1977, 171-172, DOI: 10.1039/C39770000171

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Hydrogel treatment targets tumours

27 Aug 2013

Hydrogels of cancer drug taxol injected directly into tumours have been shown to be more effective at inhibiting tumour growth than intravenous taxol injections of four times the dosage.

Taxol is used to treat many forms of cancer, including breast, lung and ovarian cancer. Its administration is typically every three weeks by intravenous injection and it can take several hours to achieve the required dose.

Hydrogels have great potential to reduce the dosing frequency of chemotherapy. They can hold exceptionally high drug loadings that are released in a controlled and sustained manner. However, synthesising such hydrogels is complex, ultimately resulting in low yields.

Zhimou Yang and fellow researchers at Nankai University in China have successfully simplified the synthesis of taxol hydrogels. Their hydrogel contains taxol conjugated to folic acid. The folic acid facilitates tumour targeting as many cancer cells have folic acid receptors so the hydrogels will sustainably release their taxol cargo through ester bond hydrolysis at the site of cancer cells.

Read the full article on Chemistry World.

Disulfide bond reduction-triggered molecular hydrogels of Folic acid-Taxol conjugates
Chengbiao Yang et al.
DOI: 10.1039/C3OB40969D

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RSC Organic Division Poster Symposium 2013, sponsored by F. Hoffmann-La Roche, Ltd.

24 Jul 2013

The poster symposium, for final year organic chemistry PhD students, will take place at The Chemistry Centre, Burlington House, London on Monday 2nd December 2013. The symposium offers final year PhD students a chance to showcase their research to their peers, leading academics and industrial chemists, and is open to all branches of organic chemistry.

The symposium has a tradition of being the most competitive and highly regarded organic chemistry symposium for PhD students in the UK, with generous support provided by F. Hoffmann-La Roche, Ltd. There will be a first prize of £500, two runner-up prizes of £250, and a “selected by Industry Prize”. Industrial delegates will be asked to make this selection with a particular emphasis on the potential for application in an industrial context and the winner will also receive a prize of £500.

Closing date for submissions is Wednesday 2nd October. Further information and abstract submission, via the online submission form, can be found on the symposium webpage.

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Meet the team at ESOC 2013

26 Jun 2013

I will shortly be attending the 18th European Symposium on Organic Chemistry (ESOC 2013) held in Marseilles, France, 7-12 July, and if you too are in attendance, I’d love to meet you there!

Dr Marie Cote, Oganic & Biomolecular Chemistry Deputy Editor

Please let us know if you will also be in attendance and would like to arrange a meeting – simply email us at the OBC editorial office.

OBC is delighted to be a media partner of the conference, and there’s lots to look forward to again on this 18th edition of the symposium:

Prof. Ben Feringa (University of Groningen, The Netherlands) will be presented with the 2013 Lilly European Distinguished Award,
Prof. Nazario Martin (Universidad Complutense de Madrid, Spain) is the recipient of the 2012 EuCheMs Lecture Award, and
Dr Joel Turconi (Sanofi, France) will present the SANOFI Lecture

Plenary lectures at the symposium will be given by :

Prof. Alexandre Alexakis (University of Geneva, Swiss)
Prof. Fernando P. Cossio (University of the Basque Country, Spain)
Prof. Ben Davis (University of Oxford, UK)
Prof. Frank Glorius (University of Muenster, Germany)
Prof. David MacMillan (Princeton University, USA)
Prof. Eiichi Nakamura (University of Tokyo, Japan)
Prof. Michael Orfanopoulos (University of Crete, Greece)
Prof. Joost Reek (Van ‘t Hoff Institute for Molecular Sciences, The Netherlands)
Prof. Raffaele Riccio (Universita degli studi di Salerno, Italy)
Prof. Doug Stephan (University of Toronto, Canada)

Access the full scientific programme

I look forward to meeting many of you in Marseilles!

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Bursary opportunity for final year PhD students and postdocs to attend the Sao Paulo Advanced School Bioorganic Chemistry

16 Apr 2013

The RSC is delighted to announce a fantastic bursary opportunity for PhD students/post docs to attend the Advanced School Bioorganic Chemistry taking place in Araraquara, Brazil, 30 June – 05 July 2013. The school includes talks and discussion sessions from highly qualified scientists (including Professor Steven V. Ley from the University of Cambridge) and leaders in the field covering bioorganic chemistry, involving aspects of natural products, medicinal chemistry, synthesis and spectroscopic methods. The full programme can be viewed here: http://www.bioorgchemespca.iq.unesp.br/nodes/view/program

FAPESP (Sao Paulo Research Foundation) have invited the RSC to select 2 UK students to participate in the meeting. The bursary will cover international and domestic transportation, hotel accommodation, meals, registration fee and welcome reception. To apply please complete the form which is available download here and at the end of this post. Return to science@rsc.org by 19 April 2013 at 4pm.

Closing date for application is 4pm on 19 April 2013

For any queries please contact science@rsc.org

Application Form for the Advanced School Bioorganic Chemistry

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Biocatalysis: an article collection

05 Oct 2012

Beers, wines and cheeses are enjoyed around the world today and have been for millennia. In fact the practices of brewing and cheese-making pre-date recorded history so it is difficult to accurately determine when we first started using naturally occurring enzymes and microorganisms to create valuable (and in this case, tastier!) products.

Biocatalysts are of course used in far more diverse applications than the creation of food-stuffs, including in many organic syntheses and in the generation of fine chemicals. Due to their natural design, they can offer superior selectivity for particular products and have a far lower environmental impact than many traditional catalysts. Our knowledge and understanding of biocatalysts has increased dramatically in the last few decades, which has allowed us to develop biologically modified and biomimetic catalysts for a range of applications.

To keep you up to date with the latest advances in this rapidly expanding field we have collected together these high impact articles and made them free to access until the 31^st October!

Click here for the full list of free articles

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Organic & Biomolecular Chemistry Blog