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We can’t quite believe it but this year Organic & Biomolecular Chemistry is going to be 10 years old!
To celebrate this we will be publishing an issue later this year that features some of the best work by chemists from across the broad scope of the journal, many of whom have served on our Editorial or Advisory Boards over the years.
Leading up to the issue we’ll be bringing you some of our ‘Top 10s’ from the journal…watch this space!
Timothy Donohoe et al. from the University of Oxford review recent developments in the synthesis of furan, pyrrole and pyridine heterocycles via cross-metathesis methods in this Emerging Area article.
It’s free to access for 4 weeks, so take a look…
Olefin cross-metathesis for the synthesis of heteroaromatic compounds
Timothy J. Donohoe, John F. Bower and Louis K. M. Chan
DOI: 10.1039/C2OB06659A
This OBC Hot Article by Paul J. Stevenson and co-workers at Queens University (Belfast) and Celtic Catalysts Ltd (Dublin) highlights the chemoenzymatic synthesis of a Lewis basic phosphine–phosphine oxide organocatalyst from a cis-dihydrodiol metabolite of bromobenzene.
Of particular interest is the impressively facile Arbuzov [2,3]-sigmatropic rearrangement reaction that the team observed – a pivotal step for this synthesis.
Reference
Chemoenzymatic synthesis of a mixed phosphine–phosphine oxide catalyst and its application to asymmetric allylation of aldehydes and hydrogenation of alkenes
Derek R. Boyd, Mark Bell, Katherine S. Dunne, Brian Kelly, Paul J. Stevenson, John F. Malone and Christopher C. R. Allen
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C1OB06599H, Paper
Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction
Karen Ka-Yan Kung, Gai-Li Li, Lan Zou, Hiu-Chi Chong, Yun-Chung Leung, Ka-Hing Wong, Vanessa Kar-Yan Lo, Chi-Ming Che and Man-Kin Wong
DOI: 10.1039/C1OB06429K
Hydroxyapatite-supported Cu(I)-catalysed cyanation of styrenyl bromides with K4[Fe(CN)6]: an easy access to cinnamonitriles
Debasree Saha, Laksmikanta Adak, M. Mukherjee and Brindaban C. Ranu
DOI: 10.1039/C1OB06467C
View the rest of the issue including a review on squaraine dyes in photodynamic therapy
B. V. Subba Reddy et al. report the stereoselective synthesis of cis– and trans-fused bicyclic and tricyclic tetrahydropyran scaffolds. Their method involves DDQ oxidation to activate the benzylic C-H of various benzyl ethers and subsequent intramolecular Prins cyclization to give the dioxa-bicycles and oxatricycles.
Read the details for free for the next 4 weeks…..
Oxidative Prins and Prins/Friedel–Crafts cyclizations for the stereoselective synthesis of dioxabicycles and hexahydro-1H-benzo[f]isochromenes via the benzylic C–H activation
B. V. Subba Reddy, Prashant Borkar, J. S. Yadav, P. Purushotham Reddy, A. C. Kunwar, B. Sridhar and René Grée
DOI: 10.1039/C1OB06489D
In this OBC Hot Paper Huaqiang Zeng and coworkers at the National University of Singapore have studied a series of water-binding aquafoldamers, illustrating their potential use for recognizing larger water clusters of diverse topologies and as synthetic water channels.
Reference:
Synthesis, structural investigation and computational modelling of water-binding aquafoldamers
Huaiqing Zhao, Wei Qiang Ong, Xiao Fang, Feng Zhou, Meng Ni Hii, Sam Fong Yau Li, Haibin Su and Huaqiang Zeng
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C1OB06609A
Synthesis of heparin oligosaccharides and their interaction with eosinophil-derived neurotoxin
Shang-Cheng Hung, Xin-An Lu, Jinq-Chyi Lee, Margaret Dah-Tsyr Chang, Shun-lung Fang, Tan-chi Fan, Medel Manuel L. Zulueta and Yong-Qing Zhong
DOI: 10.1039/C1OB06415K
The DNA three-way junction as a mould for tripartite chromophore assembly
Markus Probst, Daniel Wenger, Sarah M. Biner and Robert Häner
DOI: 10.1039/C1OB06400B
The OBC team will be attending a number of conferences in 2012 and we would be delighted to meet you.
Dr Marie Cote, Deputy Editor
Dr Richard Kelly, Managing Editor
Please let us know if you are planning on attending any of these meetings, as it would be lovely to meet you there!
Following our latest OBC Hot Article by Prof. Bradley D. Smith (available here), Squaraines are in the spotlight again in this review article by Danaboyina Ramaiah et al..
The Perspective highlights the recent developments of squaraines as PDT sensitizers, including:
Timely and HOT, why not read this Perspective now – it will be FREE to access for the next 4 weeks
Squaraine dyes in PDT: from basic design to in vivo demonstration
Rekha R. Avirah, Dhanya T. Jayaram, Nagappanpillai Adarsh and Danaboyina Ramaiah
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C1OB06588B, Perspective
