OBC 10th anniversary art gallery

A selection of images suggested for the cover of OBC’s 10th anniversary themed issue

With the 10th anniversary themed issue of OBC now online we thought we would share with you a couple of the other cover suggestions that were put forward by authors for this issue.

Below is the rather striking suggestion from Brimble et al. The tree and leaves represent nature, and its dew, superimposed with their spiroacetal-triazoles, drops into a pool of tablets representing the development of new therapeutic agents.

 

Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds
Jui Thiang Brian Kueh, Ka Wai Choi and Margaret A. Brimble
DOI: 10.1039/C2OB06802H

This second suggestion comes from Luh et al., featuring a decameric ladderphane in recognition of the 10 years that OBC has been published.

Double stranded polymeric ladderphanes with 16-π-electron antiaromatic metallocycle linkers
Hsin-Hua Huang , Chih-Gang Chao, Shern-Long Lee, Hung-Jen Wu, Chun-hsien Chen and Tien-Yau Luh
DOI: 10.1039/C2OB25114K

Now you’ve seen the art, why not see the science? View the entire issue, featuring 68 articles from the breadth of OBC‘s scope by leaders in the field!

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Organic & Biomolecular Chemistry 10th anniversary themed issue now online: 68 great articles!

The 10th anniversary issue of OBC has arrived! This celebratory issue contains a massive 68 articles of great science from investigators at the forefront of current research. View the entire issue here….

This nice front cover is courtesy of Eric H. Fort and Lawrence T. Scott who report the high reactivity of dimesitylbisanthene toward bay region air oxidation, leading to a bay region quinine. Fort and Scott say that “this finding signals a warning about the potential oxygen-sensitivity of hydrogenterminated carbon nanotubes; a single oxidation of this sort on the cylindrical rim of a growing carbon nanotube would preclude further elongation of the tube by the Diels–Alder cycloaddition/rearomatization protocol and would thereby terminate the growth.”

Facile air-oxidation of large aromatic hydrocarbon bay regions to bay region quinones: predicted oxygen-sensitivity of hydrogen-terminated carbon nanotubes
Eric H. Fort and Lawrence T. Scott

Also geared towards celebrating our 10th anniversary is this inside cover from Naoki Komatsu et al., which highlights their paper reporting on the optical enrichment of single-walled carbon nanotubes (SWNTs) with (n,m) other than those so far reported, together with their simultaneous separation according to their diameters by preferential extraction of commercial SWNTs with 2,6-pyridylene-bridged chiral diporphyrin nanotweezers.

Preferential extraction of left- or right-handed single-walled carbon nanotubes by use of chiral diporphyrin nanotweezers
Gang Liu, Tatsuki Yasumitsu, Li Zhao, Xiaobin Peng, Feng Wang, Ajoy K. Bauri, Shuji Aonuma, Takahide Kimura and Naoki Komatsu

In an issue packed with work from some of the best researches around there was always going to be a lot of HOT articles included, too many to list here. So, for the complete list of the HOT articles from this issue please have a look at our recent blog highlighting them.

Finally, the entire Organic & Biomolecular Chemistry team we would like to thank all of our Associate Editors, Editorial and Advisory Board members, authors and referees, without whom none of this past decade would have been possible, and we hope to work with you all to make the next 10 years even more successful.

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HOT articles from 10th anniversary themed issue of Organic & Biomolecular Chemistry

A collection of the HOT articles in OBC’s upcoming 10th anniversary themed issue

After much anticipation the themed issue marking the 10th anniversary of Organic & Biomolecular Chemistry will be published this week, and it’s a bumper issue full of work from many at the forefront of current research who have continued contribute to the success of OBC over the past decade.

Ahead of the issue’s publication we have prepared a FREE collection of all the HOT articles that can be found within its covers, and considering all the talent that has contributed it is quite a big collection. These will all be free to access until the end of July.

Click here for the full list

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Meet the team at BOSS XIII

I will shortly be attending the 13th Belgian Organic Synthesis Symposium (BOSS XIII) in Leuven, 15-20 July, and if you too are in attendance, I’ d love to meet you there!

Please let us know if you will also be in attendance and would like to arrange a meeting – simply email us at the OBC editorial office.

Dr Marie Cote, Oganic & Biomolecular Chemistry Deputy Editor

OBC is delighted to be a media partner of the conference, and there’s a lot to look forward to again on this 13th edition of the symposium:

  • Prof. Ben Feringa (University of Groningen, The Netherlands) is the  Tetrahedron Chair 2012 awardee, and will give lectures all throughout the opening day on ‘Exploring chiral space in asymmetric catalysis’.
  • Prof. Illan Marek (Technion – Israel Institute of Technology) is the recipient of the 2012 Janssen Pharmaceutica Prize for Creativity in Organic Synthesis

Plenary lectures at the symposium will be given by :

  • Prof. Matthias Beller (University of Rostock, Germany)
  • Prof. Dale L. Boger (The Scripps research institute, La Jolla, USA)
  • Prof. Jan-Erling Backvall (Stockholm University, Sweden)
  • Prof. Karl Gademann (University of Basel, Switzerland)
  • Prof. Frank Glorius (University of Muenster, Germany)
  • Prof. Veronique Gouverneur (University of Oxford, UK)
  • Prof. Shu Kobayashi (University of Tokyo, Japan)
  • Professor Michael Krishe (University of Texas, Austin, USA)
  • Dr Emmanuel Lacote (ICSN – CNRS, France)
  • Prof. Istvan Marko (UCL, Belgium)
  • Prof. Gary A. Molander (University of Pennsylvania, USA)
  • Prof. Klaus Mueller (F. Hoffmann-La Roche, Switzerland)
  • Prof. Tobias Ritter (Harvard University, USA)
  • Prof. Scott Snyder (Columbia University, USA)
  • Prof. Paul A. Wender (Stanford University, USA)
  • Prof. Ming Hua Xu (Shanghai Institute of Materia Medica, PR China)

I look forward to meeting you in Leuven!

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Organic: Natural products with anti-inflammatory, sedative, and antispasmodic activities synthesised

Scientists in Switzerland have carried out the asymmetric synthesis of the 12-membered lactone alkaloids (+)-vertine and (+)-lythrine (structurally related and possessing a range of bioactivities), which has so far proved a challenge.

Peter Kundig and his group employed a range of strategies and novel tactics to overcome the synthetic challenge, and the strain in the two diastereomeric 12-membered lactone alkaloids was ultimately overcome via Z-selective alkene metathesis.

Asymmetric synthesis of (+)-vertine and (+)-lythrine
Peter Kundig, Laetitia Chausset-Boissarie, Roman Arvai, Graham Cumming and Laure Guénée
DOI: 10.1039/C2OB25880C

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OBC issue 29 online now: radicals, ladderane lipids and Porphyrin–DNA conjugates

Storming the castle on the cover of this week’s issue of OBC is the communication from Dustin H. Nouri and Dean J. Tantillo (winner of the 2012 NPR Lectureship) that presents quantum chemical calculations of a possible decomposition process for ladderane lipids. Nouri and Tantillo propose that hydrogen atom abstraction next to the ladderane core can lead to the opening of the cyclobutane rings that make up the ladderane substructure, and protonation leads directly to fragmentation.

Attack of radicals and protons on ladderane lipids: quantum chemical calculations and biological implications
Dustin H. Nouri and Dean J. Tantillo
DOI: 10.1039/C2OB25717C

This interesting inside cover (left) highlights the work of Gevorg Sargsyan and Milan Balaz, who report the synthesis, self-assembly, stability, and spectroscopic studies of short alternating non-self-complementary DNA sequences 5′-(dGdA)4 and 5′-(dAdG)4 with non-charged tetraarylporphyrins covalently linked to the 5′ position of deoxyadenosine or deoxyguanosine via a phosphate or amide linker.

Porphyrin–DNA conjugates: porphyrin induced adenine–guanine homoduplex stabilization and interduplex assemblies
Gevorg Sargsyan and Milan Balaz
DOI: 10.1039/C2OB25710F

These cover articles are free to accesss for 6 weeks. Also in this issue is this HOT article, which is free to access for 4 weeks:

Locking high energy 1D chain of dichloromethane molecules containing abnormally short Cl⋯Cl contacts of 2.524 Å inside organic crystals
Feng Zhou, Haoliang Fu, Wei Qiang Ong, Ruijuan Ye, Weixing Yuan, Yu-Jing Lu, Yan-Ping Huo, Kun Zhang, Haibin Su and Huaqiang Zeng

Read the complete issue here….

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HOT: Abnormally short Cl⋯Cl contacts inside organic crystals

This HOT Communication from Huaqiang Zeng and co-workers describes a 1D helical channel, composed of short foldamers with sticky ends that self-assemble in the solid state, that acts as a CH2Cl2 channel. What is interesting is that the Cl⋯Cl intermolecular distances within the channel are extraordinarily short. Zeng et al. perform computational modelling and calculate that this unusually short distance destabilises the host–guest complex by 14.94 kcal mol-1.

This will be free to access for the next 4 weeks so why not have a look at modelling details.

Locking high energy 1D chain of dichloromethane molecules containing abnormally short Cl⋯Cl contacts of 2.524 Å inside organic crystals
Feng Zhou, Haoliang Fu, Wei Qiang Ong, Ruijuan Ye, Weixing Yuan, Yu-Jing Lu, Yan-Ping Huo, Kun Zhang, Haibin Su and Huaqiang Zeng
DOI: 10.1039/C2OB25888A

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Submit a poster for Lipids and Membrane Biophysics: Faraday Discussion 161

There’s still just time to submit a poster for Lipids and Membrane Biophysics: Faraday Discussion 161  – by the deadline date 13 July.

This Faraday Discussion will consider recent developments in the study of biomembrane structure, ordering and dynamics, with particular emphasis on the roles of lipids in these phenomena. Registration is quick and simple via our online booking system, so act today and benefit from early bird savings.

Why choose to come to a Faraday Discussion? They have a unique format – all papers are circulated in advance and all discussion contributions are recorded for publication in the abstract book after the event. You can also have your own poster space at the meeting, so submit yours now  before the deadline of 13 July.

Come and discuss new experimental and theoretical findings and novel methodologies, as we focus on exploring the relevance of concepts from amphiphile self-assembly and soft matter physics to understanding biomembranes.

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ICPOC21: poster abstracts

There is still just time to submit your poster abstract to the 21st IUPAC International Conference on Physical Organic Chemistry (ICPOC 21) but don’t delay as the deadline is 13 July.

Register early for the best prices.

Why join ICPOC21?

Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

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Top ten most accessed articles in May

This month sees the following articles in Organic & Biomolecular Chemistry that are in the top ten most accessed:

PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes
Pei Liu, Ying-Ming Pan, Yan-Li Xu and Heng-Shan Wang
Org. Biomol. Chem., 2012, 10, 4696-4698
DOI: 10.1039/C2OB25487E

A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin–hemicyanine hybrid
Zhenghao Yang, Zhipeng Liu, Yuncong Chen, Xiaoqing Wang, Weijiang He and Yi Lu
Org. Biomol. Chem., 2012, 10, 5073-5076
DOI: 10.1039/C2OB25516B

Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids
Fangxi Xu, Dan Huang, Xufeng Lin and Yanguang Wang
Org. Biomol. Chem., 2012, 10, 4467-4470
DOI: 10.1039/C2OB25663K

One-pot synthesis of 1,2,3-triazoles from boronic acids in water using Cu(II)–ß-cyclodextrin complex as a nanocatalyst
Babak Kaboudin, Yaghoub Abedi and Tsutomu Yokomatsu
Org. Biomol. Chem., 2012, 10, 4543-4548
DOI: 10.1039/C2OB25061F

The ligand and base-free Pd-catalyzed oxidative Heck reaction of arylboronic acids and olefins
Peng Sun, Yan Zhu, Hailong Yang, Hong Yan, Linhua Lu, Xiang Zhang and Jincheng Mao
Org. Biomol. Chem., 2012, 10, 4512-4515
DOI: 10.1039/C2OB25462J

Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones
David J. Aitken, Angela M. Bernard, Francesca Capitta, Angelo Frongia, Régis Guillot, Jean Ollivier, Pier Paolo Piras, Francesco Secci and Marco Spiga
Org. Biomol. Chem., 2012, 10, 5045-5048
DOI: 10.1039/C2OB25813G

First total synthesis of (+)-indicanone
Yujiro Hayashi, Kumiko Ogawa, Fuyuhiko Inagaki and Chisato Mukai
Org. Biomol. Chem., 2012, 10, 4747-4751
DOI: 10.1039/C2OB25500F

Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct
Martin Golkowski, Carlo Pergola, Oliver Werz and Thomas Ziegler
Org. Biomol. Chem., 2012, 10, 4496-4499
DOI: 10.1039/C2OB25440A

Synthesis of diversely 1,3,5-trisubstituted pyrazoles via 5-exo-dig cyclization
Dmitry A. Borkin, Mirela Puscau, Alena Carlson, Agnes Solan, Kraig A. Wheeler, Béla Török and Roman Dembinski
Org. Biomol. Chem., 2012, 10, 4505-4508
DOI: 10.1039/C2OB25580D

Thiol–yne coupling: revisiting old concepts as a breakthrough for up-to-date applications
Alessandro Massi and Daniele Nanni
Org. Biomol. Chem., 2012, 10, 3791-3807
DOI: 10.1039/C2OB25217A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Organic & Biomolecular Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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