Organic chemistry Symposium – Tohoku University


We’ve just completed a great first day of the Japan Organic Chemistry Symposia.

Hosted by Professor Masahiro Terada at Tohoku University, the symposium featured speakers from the host university, Nihon University and Hokkaido University, along with international members of our journals’ Editorial Boards.

Tohoku University students outside the auditorium

First up was Professor Hidetoshi Tokuyama from Tohoku University, presenting on his syntheses of dihydrooxepine-containing epidithiodiketopiperazine natural products, then Erik Sorensen from Princeton University and the Editorial Board of Organic Chemistry Frontiers talked about some of his latest research in C-H functionalization.

Professor Tokuyama presenting

After lunch the packed audience saw talks from Professor Hiroyuki Isobe from Tohoku University on his latest research on cycloarylenes, and then Huw Davies from Emory University and the ChemSocRev Editorial Board talked about the NSF CCI Center for Selective C-H Functionalization, a really innovative collaboration between researchers in the US.

The packed audience in Sendai

Mid-afternoon saw some great Invited lectures by early career faculty: Professors Nozomi Saito and Shintaro Ishida from Tohoku University, Tsuyoshi Mita from Hokkaido University and Atsushi Kobayashi from Nihon University.

Hosts, speakers and the Royal Society of Chemistry team

The day was rounded off with plenary lectures from Professor Masaya Sawamura from Hokkaido University on hydrogen bonding with nonpolar sp3 C-H bonds in enantioselective cooperative metal catalysis, and Professor Margaret Brimble from University of Auckland and the Organic & Biomolecular Chemistry Editorial Board on some of her latest syntheses of benzannulated spiroketal natural products.

We’d like to thank Professor Terada and his colleagues for making it such a great symposium!

Speaker abstracts and biographies

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Japan Organic Chemistry Symposia – June 2015

This week the Royal Society of Chemistry is visiting three institutes in Japan for our 2015 Organic Chemistry Symposia. We’ll be at Tohoku University on Monday 1st June, University of Tokyo on Wednesday 3rd and Kyoto University on Friday 5th.

Each symposium will feature speakers from Japanese universities along with three international speakers who will travel to each institute.

The symposia are presented by our journals Organic & Biomolecular Chemistry and Organic Chemistry Frontiers, and supported by ChemComm, Chemical Society Reviews and Chemical Science. We’re very grateful to our hosts -Professor Masahiro Terada in Sendai, Professor Masayuki Inoue in Tokyo and Professor Keiji Maruoka in Kyoto – for their support for these events.

We hope to see you at one of the symposia!

More details about the symposia, including schedules and biographies:
Sendai
| Tokyo | Kyoto

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Meet the team at ESOC 2015

Next month I will be attending the 19th European Symposium on Organic Chemistry (ESOC 2015) held in Lisbon, Portugal, 12 – 16 July, and if you too are in attendance, I’d love to meet you there!

Dr Marie Cote, Oganic & Biomolecular Chemistry Deputy Editor

Please let us know if you will also be in attendance and would like to arrange a meeting – simply email us at the OBC editorial office.

OBC, ChemComm, Chemical Science and MedChemComm are delighted to be media partners of the conference, and there’s lots to look forward to again on this 19th edition of the symposium:

  • Prof. Peter Chen (ETH Zurich, Switzerland) will be presenting the Patai Rappoport Lecture 2015,
  • Prof. Christina Moberg (KTH School of Chemical Science and Engineering, Sweden) is the recipient of the 2014 EuCheMs Lecture Award, and
  • Prof. Nuno Maulide (University of Vienna, Austria) will present the Young Researcher Award Lecture

Plenary lectures at the symposium will be given by :

  • Prof. Carlos A. M. Afonso (University of Lisbon, Portugal)
  • Prof. Ernest Giralt (Institute for Research in Biomedicine, Spain)
  • Prof. Guy Lloyd-Jones (University of Edinburgh, UK)
  • Prof. Ilan Marek (Technion – Israel Institute of Technology, Israel)
  • Prof. Peter H. Seeberger (Max Planck Institute of Colloids and Interfaces, Germany)
  • Prof. Timothy M. Swager (MIT, USA)
  • Prof. F. Dean Toste (UC Berkeley, USA)
  • Prof. Dirk Trauner (University of Munich, Germany)
  • Prof. Helma Wennemers (ETH Zurich, Switzerland)

Access the full scientific programme

    Will you be presenting a poster?

    ChemComm, OBC and MedChemComm will each be awarding a Poster Prize at ESOC 2015

    I look forward to meeting many of you in Lisbon!

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Introducing OBC Associate Editor Prof. Christian Hackenberger

Professor Christian Hackenberger has joined Organic & Biomolecular Chemistry as an Associate Editor. We are delighted to welcome him to the team and look forward to working with him over the coming years.

Christian completed his graduate studies with Prof. Sam Gellman (Univeristy Wisconsin-Madison) and his doctoral work with Prof. Carsten Bolm at the Rhine-Westphalia Institute of Technology Aachen. After his postdoctoral stay in the group of Prof. Barbara Imperiali at MIT he started his own lab at the Freie Universität Berlin as a FCI-Liebig-Scholar and Emmy Noether Fellow in 2005. In 2012, he accepted a position as the Leibniz–Humboldt Professor for Chemical Biology to the Leibniz Institut for Molecular Pharmacology and the Humboldt Universität zu Berlin.

Christian’s research interests focus around studying the biology, function and pharmacological potency of naturally and unnaturally modified peptides and proteins and include:

  • Development of ligation and modification strategies for the synthesis of functional proteins
  • Bioorthogonal Staudinger phosphite and phosphonite reactions
  • Labeling strategies for antibody ‐ and nanobody conjugates
  • Intracellular delivery and targeting
  • Protein and peptide PEGylation
  • Functional investigation of the Alzheimer‐relevant Tau protein
  • Engineering of protein‐based multivalent scaffolds
  • Metabolic oligosaccharide engineering

On starting his new role as Associate Editor for  Organic & Biomolecular Chemistry Christian said:

I am delighted to act as an associate editor to OBC. Without a question I am very happy about the nomination from the editorial board, especially because I published my very first independent paper back in 2006 in OBC. This new job is both a privilege and an honor to serve the community and work with the editorial team of the Royal Society of Chemistry

Submit a manuscript for Christian to handle
Visit Christian’s homepage

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Organic chemistry’s complexity conundrum

Organic synthesis is often heralded as more art than science. An organic chemist’s eye for complexity, breaking down structures into simpler forms, is honed and nurtured over decades. But, is it possible to take this seemingly intangible skill and quantify it, putting a simple number on how complex a chemical structure actually is?

Process chemists Martin Eastgate and Jun Li, at Bristol-Myers Squibb (B-MS) in the US have developed a tool to do just that, generating a unique index they have termed a molecule’s current complexity, which also accounts for changes over time due to the impact of new technologies.


Read the full Chemistry World story»

Read the original Organic & Biomolecular Chemistry article – it’s free to access until 2nd July:
Current complexity: a tool for assessing the complexity of organic molecules

Jun Lia and Martin D. Eastgate
Org. Biomol. Chem., 2015, DOI: 10.1039/C5OB00709G

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Agri Innovation 2015

Join us on 22 April at the Society of Chemical Industry in London for Agri Innovation 2015: Emerging Technologies in Crop Research

This one-day meeting aims to provide an update on several areas of crop research, including identifying target proteins for crop protection ingredients, the synthesis of new crop protection agents and understanding the mechanisms of resistance and immunity in plants and insects. If you are working in organic synthesis, chemical biology or biochemistry in relation to crop science, this meeting will provide an opportunity to catch up on the latest developments. Speakers from academia and industry from across Europe will come together to present and discuss the latest developments in this area.

The meeting is jointly run by the Royal Society of Chemistry, the Society of Chemical Industry Agrisciences Group and AGRI-net, the agriscience chemical biology network. For more details and to register, please visit the website.

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HOT Organic & Biomolecular Chemistry articles

The following Organic & Biomolecular Chemistry articles have all been recommened by the reviewers of the articles as being particularly interesting or particularly significant research. These have all been made free to access until 20th April 2015. The order they appear in the list holds no special meaning or ranking.

Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media
Wen-Peng Mai, Bin Sun, Li-Qin You, Liang-Ru Yang, Pu Mao, Jin-Wei Yuan, Yong-Mei Xiao and Ling-Bo Qu
DOI: 10.1039/C4OB02524E

10.1039/C4OB02524E


Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins
Clare S. Mahon, Martin A. Fascione, Chadamas Sakonsinsiri, Tom E. McAllister, W. Bruce Turnbull and David A. Fulton
DOI: 10.1039/C4OB02587C

10.1039/C4OB02587C


Oxidative asymmetric umpolung alkylation of Evans’ β-ketoimides using dialkylzinc nucleophiles
Tom A. Targel, Jayprakash N. Kumar, O. Svetlana Shneider, Sukanta Bar, Natalia Fridman, Shimon Maximenko and Alex M. Szpilman
DOI: 10.1039/C4OB02601B

10.1039/C4OB02601B


Cyclopropanation using flow-generated diazo compounds
Nuria M. Roda, Duc N. Tran, Claudio Battilocchio, Ricardo Labes, Richard J. Ingham, Joel M. Hawkins and Steven V. Ley
DOI: 10.1039/C5OB00019J, Communication

10.1039/C5OB00019J


Supramolecular control of transition metal complexes in water by a hydrophobic cavity: a bio-inspired strategy
Olivia Bistri and Olivia Reinaud
DOI: 10.1039/C4OB02511C

10.1039/C4OB02511C


Cyclopenta[b]naphthalene cyanoacrylate dyes: synthesis and evaluation as fluorescent molecular rotors
Laura S. Kocsis, Kristyna M. Elbel, Billie A. Hardigree, Kay M. Brummond, Mark A. Haidekker and Emmanuel A. Theodorakis
DOI: 10.1039/C4OB02563F

10.1039/C4OB02563F


Chiral nanostructuring of multivalent macrocycles in solution and on surfaces
Marco Caricato, Arnaud Delforge, Davide Bonifazi, Daniele Dondi, Andrea Mazzanti and Dario Pasini
DOI: 10.1039/C4OB02643H

10.1039/C4OB02643H


Physicochemical studies on the copper(II) binding by glycated collagen telopeptides
Meder Kamalov, Paul W. R. Harris, Christian G. Hartinger, Gordon M. Miskelly, Garth J. S. Cooper and Margaret A. Brimble
DOI: 10.1039/C4OB02536A
Regiodivergent Lewis base-promoted O- to C-carboxyl transfer of furanyl carbonates
Craig D. Campbell, Caroline Joannesse, Louis C. Morrill, Douglas Philp and Andrew D. Smith
DOI: 10.1039/C4OB02629B

10.1039/C4OB02536A


Total syntheses of five uvacalols: structural validation of uvacalol A, uvacalol B and uvacalol C and disproval of the structures of uvacalol E and uvacalol G
Adiyala Vidyasagar and Kana M. Sureshan
10.1039/C4OB0266310.1039/C4OB02663B B


Direct biosynthetic cyclization of a distorted paracyclophane highlighted by double isotopic labelling of L-tyrosine
Alexandre Ear, Séverine Amand, Florent Blanchard, Alain Blond, Lionel Dubost, Didier Buisson and Bastien Nay
DOI: 10.1039/C5OB00114E

10.1039/C5OB00114E


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HOT Organic & Biomolecular Chemistry articles

The following Organic & Biomolecular Chemistry articles have all been recommened by the reviewers of the articles as being particularly interesting or particularly significant research. These have all been made free to access until 16th March 2015. The order they appear in the list holds no special meaning or ranking.

E. coli cells expressing the Baeyer–Villiger monooxygenase ‘MO14’ (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor
Benjamin D. Summers, Muhiadin Omar, Thomas O. Ronson, Jared Cartwright, Michael Lloyd and Gideon Grogan
DOI: 10.1039/C4OB01441C, Paper
From themed collection In Celebration of Richard Taylor’s 65th Birthday

C4OB01441C GA


Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity
Samuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rüdiger Woscholski and Piers R. J. Gaffney
DOI: 10.1039/C4OB02258K, Paper

C4OB02258K GA


A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones
Marc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant and Luke R. Odell
DOI: 10.1039/C4OB02417F, Paper

C4OB02417F GA


Near-instant surface-selective fluorogenic protein quantification using sulfonated triarylmethane dyes and fluorogen activating proteins
Qi Yan, Brigitte F. Schmidt, Lydia A. Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan K. Andreko and Marcel P. Bruchez
DOI: 10.1039/C4OB02309A, Paper

C4OB02309A GA


Bacterial patterning controlled by light exposure
Willem A. Velema, Jan Pieter van der Berg, Wiktor Szymanski, Arnold J. M. Driessen and Ben L. Feringa
DOI: 10.1039/C4OB02483D, Communication

C4OB02483D GA


Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones
Pei-Pei Yeh, David S. B. Daniels, Charlene Fallan, Eoin Gould, Carmen Simal, James E. Taylor, Alexandra M. Z. Slawin and Andrew D. Smith
DOI: 10.1039/C4OB02408G, Paper

C4OB02408G GA


Energy transfer between amphiphilic porphyrin polymer shells and upconverting nanoparticle cores in water-dispersible nano-assemblies
T. Wu, S. Kaur and N. R. Branda
DOI: 10.1039/C4OB02401J, Paper

C4OB02401J GA


Copper-catalyzed oxidative alkenylation of thioethers via Csp3–H functionalization
Hao Cao, Dong Liu, Chao Liu, Xinquan Hu and Aiwen Lei
DOI: 10.1039/C4OB02564D, Communication

C4OB02564D GA


Volatiles from nineteen recently genome sequenced actinomycetes
Christian A. Citron, Lena Barra, Joachim Wink and Jeroen S. Dickschat
DOI: 10.1039/C4OB02609H, Paper

C4OB02609H GA


Functional chromatographic technique for natural product isolation
Eric C. Lau, Damian J. Mason, Nicole Eichhorst, Pearce Engelder, Celestina Mesa, E. M. Kithsiri Wijeratne, G. M. Kamal B. Gunaherath, A. A. Leslie Gunatilaka, James J. La Clair and Eli Chapman
DOI: 10.1039/C4OB02292K, Communication

C4OB02292K GA

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OBC call for papers: Multivalent Biomolecular Recognition themed issue

Organic & Biomolecular Chemistry is delighted to announce a call for paper for its latest themed issue on: Multivalent Biomolecular Recognition

Guest Editors: Prof.  Mihail Barboiu (Institut Européen des Membranes, France),  Prof. Olof Ramström (KTH – Royal Institute of Technology, Sweden) and Prof. Stéphane Vincent (University of Namur, Belgium)

Submission Deadline: 15th July 2015

From the guest-editors:

The understanding and control of multivalent biomolecular interactions has become one of the key frontiers of chemistry and biology. This issue will cover important findings and advances in the field, in order to:
1. Develop functional sugar decorated nanoplatforms (nanoparticles, nanostructured surfaces, vesicles, microarrays, etc.).
2. Understand the biomolecular mechanisms by exploring their synergistic adaptive interactions with biomolecules, in order to accurately control the chemical/biological responses.

The inspiration for this issue comes partly from our membership of the EU-funded Dynamic Interactive Nanosystems ITN Marie Curie DYNANO Network (see http://www.dynano.eu ). We hope that colleagues from the Network will participate but are also very welcoming to contributors who have not (yet) joined our association.

Research in OBC is published as communications (for urgent work – up to 5 pages in length) or full papers. There is also the opportunity to write a Perspective or Review article for the issue, and if you would be interested in this please let us know. All submissions will be subject to rigorous peer review to meet the usual high standards of OBC.

The deadline for submissions to the themed issue is 15th July 2015, although submissions before this date are of course welcomed.

Manuscripts can be submitted using the RSC’s online submissions service. Please clearly mark that the manuscript is submitted for the themed issue on ‘Multivalent Biomolecular Recognition’.

Please would you inform the editorial office by e-mail as soon as possible if you plan to submit to the issue and whether your contribution will be original research or a review-type article. We would like to have a list of authors who intend to contribute as soon as possible.

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Meet the OBC team – See where and when you can meet us in 2015

A selection of conferences the journal will be attending in 2015.

The Organic & Biomolecular Chemistry team will be attending a number of conferences in 2015 and we would be delighted to meet you there.

We’re also the team behind OBC’s sister journals MedChemComm, Natural Product Reports, and Molecular BioSystems, so we’ll happily discuss your interdisciplinary research work. In fact, many of our authors choose to publish their research across all of these titles.

Spring

National symposium on Chemical Biology 18-19 February 2015, Mysore, India.  Meet Deeksha Gupta.

Directing Biosynthesis IV 25 – 27th March 2015, Norwich, UK. Meet Marie Cote.

MedChemComm, 27-30 April 2015, Hyderabad, India.  Meet Deeksha Gupta.

Grassmere Heterocyclic meeting 7th – 11th May, 2015, Grassmere, UK.  Meet James Anson.

Summer

Royal Society of Chemistry Organic Chemistry Symposium Series 1st – 5th June 2015, Sendai, Tokyo, Kyoto, Japan.  Meet Rich Kelly

American Peptide Symposium 20th – 25th June 2015, Orlando, Florida.  Meet Rich Kelly.

ISMSC 28th June – 2nd July 2015, Strasbourg, France.  Meet Marie Cote.

7th International Conference on Green and Sustainable Chemistry, July 5 – 8th, Tokyo, Japan.  Meet Hiromitsu Urakami.

ESOC 2015 12th – 16th July 2015, Lisbon, Portugal.  Meet Marie Cote.

RSC Organic Synthesis 20th – 23rd July 2015, Cambridge, UK.  Meet James Anson.

9th CCS National Organic Chemistry conference, 31st July to 3rd August 2015, Changchun, China.  Meet Guanqun Song.

9th National Chemical Biology conference, August, Tianjin, China.  Meet Guanqun Song.

250th ACS National Meeting & Exposition 16th – 20th August 2015, Boston, USA.

25th International Society of Heterocyclic Chemistry Conference (August 23-28) in Santa Barbara, USA. Meet Jennifer Lee.

Autumn

18th RSC/SCI medicinal chemistry conference 13th – 16th September 2015, Cambridge, UK.  Meet James Anson.

26th Symposium on Physical Organic Chemistry, 24 – 26th September,  Ehime, Japan.  Meet Hiromitsu Urakami.

13th International Kyoto Conference on New Aspects of Organic Chemistry , 9th  – 13th November, Kyoto, Japan.  Meet Hiromitsu Urakami.

Tateshina Conference, 13th – 15th November, Tateshina, Japan.  Meet Hiromitsu Urakami.

BMOS-16 15th – 19th November 2015, Buzios, Brazil.  Meet Rich Kelly.

Winter

Pacifichem 15th – 20th December 2015, Hawaii, USA.  Meet Marie Cote.

Let us know if you are planning on attending any of these meetings, as we would be happy to meet you there!

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