OBC 10th anniversary – Organic & Biomolecular Chemistry Blog

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OBC 10th anniversary art gallery

17 Jul 2012

With the 10th anniversary themed issue of OBC now online we thought we would share with you a couple of the other cover suggestions that were put forward by authors for this issue.

Below is the rather striking suggestion from Brimble et al. The tree and leaves represent nature, and its dew, superimposed with their spiroacetal-triazoles, drops into a pool of tablets representing the development of new therapeutic agents.

Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds
Jui Thiang Brian Kueh, Ka Wai Choi and Margaret A. Brimble
DOI: 10.1039/C2OB06802H

This second suggestion comes from Luh et al., featuring a decameric ladderphane in recognition of the 10 years that OBC has been published.

Double stranded polymeric ladderphanes with 16-π-electron antiaromatic metallocycle linkers
Hsin-Hua Huang , Chih-Gang Chao, Shern-Long Lee, Hung-Jen Wu, Chun-hsien Chen and Tien-Yau Luh
DOI: 10.1039/C2OB25114K

Now you’ve seen the art, why not see the science? View the entire issue, featuring 68 articles from the breadth of OBC‘s scope by leaders in the field!

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Organic & Biomolecular Chemistry 10th anniversary themed issue now online: 68 great articles!

12 Jul 2012

The 10th anniversary issue of OBC has arrived! This celebratory issue contains a massive 68 articles of great science from investigators at the forefront of current research. View the entire issue here….

This nice front cover is courtesy of Eric H. Fort and Lawrence T. Scott who report the high reactivity of dimesitylbisanthene toward bay region air oxidation, leading to a bay region quinine. Fort and Scott say that “this finding signals a warning about the potential oxygen-sensitivity of hydrogenterminated carbon nanotubes; a single oxidation of this sort on the cylindrical rim of a growing carbon nanotube would preclude further elongation of the tube by the Diels–Alder cycloaddition/rearomatization protocol and would thereby terminate the growth.”

Facile air-oxidation of large aromatic hydrocarbon bay regions to bay region quinones: predicted oxygen-sensitivity of hydrogen-terminated carbon nanotubes
Eric H. Fort and Lawrence T. Scott

Also geared towards celebrating our 10th anniversary is this inside cover from Naoki Komatsu et al., which highlights their paper reporting on the optical enrichment of single-walled carbon nanotubes (SWNTs) with (n,m) other than those so far reported, together with their simultaneous separation according to their diameters by preferential extraction of commercial SWNTs with 2,6-pyridylene-bridged chiral diporphyrin nanotweezers.

Preferential extraction of left- or right-handed single-walled carbon nanotubes by use of chiral diporphyrin nanotweezers
Gang Liu, Tatsuki Yasumitsu, Li Zhao, Xiaobin Peng, Feng Wang, Ajoy K. Bauri, Shuji Aonuma, Takahide Kimura and Naoki Komatsu

In an issue packed with work from some of the best researches around there was always going to be a lot of HOT articles included, too many to list here. So, for the complete list of the HOT articles from this issue please have a look at our recent blog highlighting them.

Finally, the entire Organic & Biomolecular Chemistry team we would like to thank all of our Associate Editors, Editorial and Advisory Board members, authors and referees, without whom none of this past decade would have been possible, and we hope to work with you all to make the next 10 years even more successful.

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HOT articles from 10th anniversary themed issue of Organic & Biomolecular Chemistry

10 Jul 2012

After much anticipation the themed issue marking the 10th anniversary of Organic & Biomolecular Chemistry will be published this week, and it’s a bumper issue full of work from many at the forefront of current research who have continued contribute to the success of OBC over the past decade.

Ahead of the issue’s publication we have prepared a FREE collection of all the HOT articles that can be found within its covers, and considering all the talent that has contributed it is quite a big collection. These will all be free to access until the end of July.

Click here for the full list

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10 of the best: Synthesis in Organic & Biomolecular Chemistry

02 Jul 2012

In this addition of OBC’s ’10 of the best’ we are bringing you a selection of 10 of our most highly cited synthesis articles. As with the other blogs, every single one will be free to access for you to enjoy until July 11th.

Design, synthesis and photophysical studies of simple fluorescent anion PET sensors using charge neutral thiourea receptors
Thorfinnur Gunnlaugsson, Anthony P. Davis, Gillian M. Hussey, Juliann Tierney and Mark Glynn
DOI: 10.1039/B404706K

The small peptide-catalyzed direct asymmetric aldol reaction in water
Pawel Dziedzic, Weibiao Zou, Jonas Háfren and Armando Córdova
DOI: 10.1039/B515880J

Synthesis of protein–polymer conjugates
Karina L. Heredia and Heather D. Maynard
DOI: 10.1039/B612355D

Advanced organic synthesis using microreactor technology
Batoul Ahmed-Omer, Johan C. Brandt and Thomas Wirth
DOI: 10.1039/B615072A

Diversity-oriented synthesis; a challenge for synthetic chemists
David R. Spring
DOI: 10.1039/B310752N

Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines
Olivier Riant and Jérôme Hannedouche
DOI: 10.1039/B617746H

Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids
Henning Vogt and Stefan Bräse
DOI: 10.1039/B611091F

Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate
Thorfinnur Gunnlaugsson, Anthony P. Davis, John E. O’Brien and Mark Glynn
DOI: 10.1039/B409018G

Syntheses of polysubstituted furans: recent developments
Stefan F. Kirsch
DOI: 10.1039/B602596J

Accelerated asymmetric transfer hydrogenation of aromatic ketones in water
Xiaofeng Wu, Xiaoguang Li, William Hems, Frank King and Jianliang Xiao
DOI: 10.1039/B403627A

Missed our other 10th anniversary posts? Take a look here for more of our top cited work from the past 10 years.

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10 of the best: Supramolecular chemistry in OBC

25 Jun 2012

This week we’re going supramolecular as we celebrate OBC’s 10th anniversary! Below is a selection of 10 of our most highly cited articles in the area of supramolecular chemistry. Every single one will be free to access for you to enjoy for the next week.

Multivalency in supramolecular chemistry and nanofabrication
Alart Mulder, Jurriaan Huskens and David N. Reinhoudt
DOI: 10.1039/B413971B

New directions in supramolecular transition metal catalysis
Matthew J. Wilkinson, Piet W. N. M. van Leeuwen and Joost N. H. Reek
DOI: 10.1039/B503407H

Nucleation–elongation: a mechanism for cooperative supramolecular polymerization
Dahui Zhao and Jeffrey S. Moore
DOI: 10.1039/B308788C

Mass spectrometric studies of non-covalent compounds: why supramolecular chemistry in the gas phase?
Bilge Baytekin, H. Tarik Baytekin and Christoph A. Schalley
DOI: 10.1039/B604265A

Artificial photosynthetic systems: assemblies of slipped cofacial porphyrins and phthalocyanines showing strong electronic coupling
Akiharu Satake and Yoshiaki Kobuke
DOI: 10.1039/B703405A

Bright molecules with sense, logic, numeracy and utility
A. Prasanna de Silva, Thomas P. Vance, Matthew E. S. West and Glenn D. Wright
DOI: 10.1039/B802963F

Tetrakis(imidazolium) macrocyclic receptors for anion binding
Wallace W. H. Wong, Matthew S. Vickers, Andrew R. Cowley, Rowena L. Paul and Paul D. Beer
DOI: 10.1039/B510068B

Anion-templated assembly of [2]rotaxanes
Mark R. Sambrook, Paul D. Beer, Michael D. Lankshear, R. Frederick Ludlow and James A. Wisner
DOI: 10.1039/B518178J

A versatile template for the formation of [2]pseudorotaxanes. 1,2-Bis(pyridinium)ethane axles and 24-crown-8 ether wheels
Stephen J. Loeb, Jorge Tiburcio, Sarah J. Vella and James A. Wisner
DOI: 10.1039/B514528G

Interlocked host rotaxane and catenane structures for sensing charged guest species via optical and electrochemical methodologies
Michał J. Chmielewski , Jason J. Davis and Paul D. Beer
DOI: 10.1039/B818351A

Take a look here for some of our top cited work, including more 10 of the bests:

bioorganic, catalysis, medicinal chemistry, natural products.

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10 of the best: Natural Products in Organic & Biomolecular Chemistry

18 Jun 2012

In the latest blog of our series celebrating OBC’s 10th anniversary we bring you a selection of 10 of our most highly cited articles in the area of natural products. Every single one will be free to access for you to enjoy for the next week.

Triggering cryptic natural product biosynthesis in microorganisms
Kirstin Scherlach and Christian Hertweck
DOI: 10.1039/B821578B

Chemistry and biology of wortmannin
Peter Wipf and Robert J. Halter
DOI: 10.1039/B504418A

[3 + 3] Cycloadditions and related strategies in alkaloid natural product synthesis
Joseph P. A. Harrity and Olivier Provoost
DOI: 10.1039/B502349C

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries
K. C. Nicolaou, Ronald M. Evans, A. J. Roecker, Robert Hughes, Michael Downes and Jeffery A. Pfefferkorn
DOI: 10.1039/B300525A

Golden opportunities in natural product synthesis: first total synthesis of (−)-isocyclocapitelline and (−)-isochrysotricine by gold-catalyzed allene cycloisomerization
Frank Volz and Norbert Krause
DOI: 10.1039/B703995F

Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition
Elin Abraham, E. Anne Brock, José I. Candela-Lena, Stephen G. Davies, Matthew Georgiou, Rebecca L. Nicholson, James H. Perkins, Paul M. Roberts, Angela J. Russell, Elena M. Sánchez-Fernández, Philip M. Scott, Andrew D. Smith and James E. Thomson
DOI: 10.1039/B801671B

Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides
Dimitrios E. Lizos and John A. Murphy
DOI: 10.1039/B208114H

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides
Panumart Thongyoo, Núria Roqué-Rosell, Robin J. Leatherbarrow and Edward W. Tate
DOI: 10.1039/B801667D

Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi
Martin G. Banwell, Alison J. Edwards, Katrina A. Jolliffe, Jason A. Smith, Ernest Hamel and Pascal Verdier-Pinard
DOI: 10.1039/B209992F

Enantioselective synthesis of (+)(R)- and (−)(S)-nicotine based on Ir-catalysed allylic amination
Carolin Welter, Rosa M. Moreno, Stephane Streiff and Günter Helmchen
DOI: 10.1039/B508634E

Missed our other 10th anniversary posts? Take a look here for some of our top cited work, including 10 of the best catalysis articles and 10 of the best medicinal chemistry articles.

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10 of the best: medicinal chemistry in Organic & Biomolecular Chemistry

12 Jun 2012

Continuing our blog series celebrating OBC’s 10th anniversary we bring you a selection of 10 of our most highly cited articles in the area of medicinal chemistry. Every single one will be free to access for you to enjoy for the next week.

Analysis of the reactions used for the preparation of drug candidate molecules
John S. Carey, David Laffan, Colin Thomson and Mike T. Williams
DOI: 10.1039/B602413K

A hitchhiker’s guide to G-quadruplex ligands
David Monchaud and Marie-Paule Teulade-Fichou
DOI: 10.1039/B714772B

HIV-1 protease: mechanism and drug discovery
Ashraf Brik and Chi-Huey Wong
DOI: 10.1039/B208248A

Cell-penetrating peptides as delivery vehicles for biology and medicine
Kelly M. Stewart, Kristin L. Horton and Shana O. Kelley
DOI: 10.1039/B719950C

Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug
Young Jin Jeon, Soo-Young Kim, Young Ho Ko, Shigeru Sakamoto, Kentaro Yamaguchi and Kimoon Kim
DOI: 10.1039/B504487A

Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase
Bérangère Guyen, Christoph M. Schultes, Pascale Hazel, John Mann and Stephen Neidle
DOI: 10.1039/B316055F

Mechanism and structure–reactivity relationships for aromatic hydroxylation by cytochrome P450
Christine M. Bathelt, Lars Ridder, Adrian J. Mulholland and Jeremy N. Harvey
DOI: 10.1039/B410729B

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones
Karl-Heinz Altmann
DOI: 10.1039/B405839A

Two-stage enzyme mediated drug release from LMWG hydrogels
Kjeld J. C. van Bommel, Marc C. A. Stuart, Ben L. Feringa and Jan van Esch
DOI: 10.1039/B507157G

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases
Mariana Hainrichson, Igor Nudelman and Timor Baasov
DOI: 10.1039/B712690P

Missed our other 10th anniversary posts? Take a look here for some of our top cited work.

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10 of the best: catalysis in Organic & Biomolecular Chemistry

04 Jun 2012

In this latest blog celebrating OBC’s 10th anniversary we bring to you a selection of 10 of the most highly cited articles that cover the area of catalysis. Every single one will be free to access for you to enjoy.

“Frustrated Lewis pairs”: a concept for new reactivity and catalysis
Douglas W. Stephan
DOI: 10.1039/B802575B

Asymmetric organocatalysis
Jayasree Seayad and Benjamin List
DOI: 10.1039/B415217B

The golden gate to catalysis
Anja Hoffmann-Röder and Norbert Krause
DOI: 10.1039/B416516K

Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors
Yoshiji Takemoto
DOI: 10.1039/B511216H

Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
Alexander J. A. Cobb, David M. Shaw, Deborah A. Longbottom, Johan B. Gold and Steven V. Ley
DOI: 10.1039/B414742A

Mechanistic aspects of transition metal catalysed 1,6-diene and 1,6-enyne cycloisomerisation reactions
Guy C. Lloyd-Jones
DOI: 10.1039/B209175P

Ru complexes bearing bidentate carbenes: from innocent curiosity to uniquely effective catalysts for olefin metathesis
Amir H. Hoveyda, Dennis G. Gillingham, Joshua J. Van Veldhuizen, Osamu Kataoka, Steven B. Garber, Jason S. Kingsbury and Joseph P. A. Harrity
DOI: 10.1039/B311496C

σ-Chelation-directed C–H functionalizations using Pd(II) and Cu(II) catalysts: regioselectivity, stereoselectivity and catalytic turnover
Jin-Quan Yu, Ramesh Giri and Xiao Chen
DOI: 10.1039/B611094K

Primary amino acids: privileged catalysts in enantioselective organocatalysis
Li-Wen Xu and Yixin Lu
DOI: 10.1039/B803116A

[2.2]Paracyclophane derivatives in asymmetric catalysis
Susan E. Gibson and Jamie D. Knight
DOI: 10.1039/B300717K

Do you remember these articles? Have they influenced your work? Share your comments below, we would love to read them.

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The best of bioorganic from Organic & Biomolecular Chemistry

25 May 2012

Continuing with our countdown to OBC’s 10th anniversary celebratory issue we’ve collected a selection of our most cited articles from the area of bioorganic chemistry and made them free to access for one week.

DNA-programmed assembly of nanostructures
Kurt V. Gothelf and Thomas H. LaBean
DOI: 10.1039/B510551J

Nucleic acid nanotechnology—towards Ångström-scale engineering
Jesper Wengel
DOI: 10.1039/B313986G

Fluorescent DNA base replacements: reporters and sensors for biological systems
James N. Wilson and Eric T. Kool
DOI: 10.1039/B612284C

Photochemical control of biological processes
Douglas D. Young and Alexander Deiters
DOI: 10.1039/B616410M

DNA meets synthetic polymers—highly versatile hybrid materials
Fikri E. Alemdaroglu and Andreas Herrmann
DOI: 10.1039/B617941J

DNA-based machines
Moritz K. Beissenhirtz and Itamar Willner
DOI: 10.1039/B607033G

Electrontransfer through DNA and metal-containing DNA
Thomas Carell, Christoph Behrens and Johannes Gierlich
DOI: 10.1039/B303754A

Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules
Paul F. van Swieten, Michiel A. Leeuwenburgh, Benedikt M. Kessler and Herman S. Overkleeft
DOI: 10.1039/B412558D

Artificial ribonucleases
Teija Niittymäki and Harri Lönnberg
DOI: 10.1039/B509022A

Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids
Arnaud Gissot, Michel Camplo, Mark W. Grinstaff and Philippe Barthélémy
DOI: 10.1039/B719280K

Missed our other 10th anniversary posts? Take a look here for some of our top cited work.

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Mannich reactions, carbon nanotubes & polymeric ladderphanes: a taste of what’s to come for Organic & Biomolecular Chemistry’s 10th anniversary issue

18 Apr 2012

Our 10th anniversary themed issue is well under way, with many articles now published online. Here is just a taster of some of the hot articles that are included in the collection so far:

Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism
Yasuhiro Yamashita, Hirotsugu Suzuki and Shu Kobayashi
DOI: 10.1039/C2OB25522G

Facile air-oxidation of large aromatic hydrocarbon bay regions to bay region quinones: predicted oxygen-sensitivity of hydrogen-terminated carbon nanotubes
Eric H. Fort and Lawrence T. Scott
DOI: 10.1039/C2OB25208B

Double stranded polymeric ladderphanes with 16-p-electron antiaromatic metallocycle linkers
Hsin-Hua Huang, Chih-Gang Chao, Shern-Long Lee, Hung-Jen Wu, Chun-hsien Chen and Tien-Yau Luh
DOI: 10.1039/C2OB25114K

Solvent and substituent effects on aggregation constants of perylene bisimide p-stacks – a linear free energy relationship analysis
Zhijian Chen, Benjamin Fimmel and Frank Würthner
DOI: 10.1039/C2OB07131B

These 4 HOT artilces will be FREE to access for the next 4 weeks.

There are plenty more articles HERE, covering many different and interesting topics. Why not take a look, we’re sure you’ll find something you will like.

In the weeks to come we will be highlighting more of the hot articles that have been published for our 10th anniversary issue so watch this space!

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