Author Archive

Poster Prize Winners at the Tri-Institutional Chemical Biology Symposium

From the whole Organic & Biomolecular Chemistry team, we’d like to say congratulations to all the poster prize winners at the Tri-Institutional Chemical Biology Symposium 2017!

We were pleased to present prizes to the following winners:


Rudolph Pisa
(Graduate student with Professor Tarun Kapoor, The Rockefeller University) – Chemical Science poster prize
A rational strategy to design probes for the chemical genetic analysis of AAA+ proteins

Darren Johnson (Graduate student with Professor Daniel Bachovchin, Memorial Sloan Kettering Cancer Centre) – Chemical Society Reviews poster prize
DPP8 and DPP9 are therapeutic targets for acute myeloid leukemia

Michaelyn Lux (Graduate student with Professor Derek Tan, Memorial Sloan Kettering Cancer Centre) – Organic & Biomolecular Chemistry poster prize
Diastereoselective palladium-catalyzed cascade to form pyranobenzofurans and furobenzofurans

Dr Nathan Westcott (Postdoc with Professor Howard Hang, The Rockefeller University) – Organic & Biomolecular Chemistry poster prize
Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress

 

You can read some related papers publishing in Organic & Biomolecular Chemistry below:

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site
James C. Burnett, Chaemin Lim, Brian D. Peyser, Lalith P. Samankumara, Marina Kovaliov, Raffaele Colombo, Stacie L. Bulfer, Matthew G. LaPorte, Ann R. Hermone, Connor F. McGrath, Michelle R. Arkin, Rick Gussio, Donna M. Huryn and Peter Wipf
From themed collection 2017 Hot Articles in Organic and Biomolecular Chemistry

Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1)
L. Chen, P. T. Wilder, B. Drennen, J. Tran, B. M. Roth, K. Chesko, P. Shapiro and S. Fletcher
From themed collection New Talent

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials

Molecular self-assembly has become one of the most prominent fields of nanotechnology in recent years. Inspired by nature, many scientists around the world are attempting to utilize it as a tool to design novel nanostructures with desired biomedical properties.

To achieve this goal, it is necessary to understand how self-assembly works and how molecular forces and other conditions drive this self-assembly and define the structure of a specific supramolecular complex.

In a recent Organic & Biomolecular Chemistry publication, Professor Charlotte J. C. Edwards-Gayle and Professor Ian W. Hamley from the University of Reading, UK, have reviewed some of the most prominent self-assembled peptide amphiphiles and their potential applications. These include tissue scaffolds, antimicrobial peptides and drug transporters.

One of the distinct features of self-assembling amphiphiles, which makes them attractive candidates for many applications, is their diversity to form various structures such as micelles, vesicles, nanotubes, fibrils and sheets (Fig.1). The self-assembly of PAs can also be tuned by several factors including amino acid sequence, peptide length, temperature, pH, and concentration.

 

These features make them perfect, novel tools to create biomaterials which can be responsive to different environmental cues. However, the review points out that the key question of whether there is a relationship between bioactivity and self-assembly of peptide amphiphiles has still remained unanswered, despite the advancement in the field.

Extending the success in designing various structures, together with distinct applications, have made peptide amphiphile self-assembly a vibrant field in which researchers will continue to develop functional constructs with novel applications.

To find out more please see:

Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials
Charlotte J. C. Edwards-Gayle and Ian W. Hamley
DOI: 10.1039/C7OB01092C


Zahra Bahrami Dizicheh is a PhD candidate in molecular biology with Dr. Giovanna Ghirlanda at Arizona State University. She does research on photo-electrochemical hydrogen production with designing and developing interconnection between conductive materials and redox proteins to develop dye-sensitized photo-electrochemical cells.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Introducing Professor Motomu Kanai, OBC Associate Editor

Professor Motomu Kanai has joined Organic & Biomolecular Chemistry as an Associate Editor. We are delighted to welcome him to the team and look forward to working with him over the coming years.

 

Motomu Kanai was born in 1967 in Tokyo, Japan, and received his bachelor degree from The University of Tokyo (UTokyo) in 1989 under the direction of late Professor Kenji Koga. In the middle of his PhD course in UTokyo (in 1992), he obtained an assistant professor position in Professor Kiyoshi Tomioka’s group of Osaka University. He obtained his PhD from Osaka University in 1995 before moving to the University of Wisconsin, USA, for postdoctoral studies with Professor Laura L. Kiessling. In 1997 he returned to Japan and joined Professor Masakatsu Shibasaki’s group in UTokyo as an assistant professor, being a lecturer (2000~2003) and an associate professor (2003~2010). He is currently a professor at UTokyo and is a principle investigator of the ERATO Kanai Life Science Project (2011~2017). He has received The Pharmaceutical Society of Japan Award for Young Scientists (2001), Thieme Journals Award (2003), Merck-Banyu Lectureship Award (MBLA: 2005), Asian Core Program Lectureship Award (2008 and 2010), and Thomson-Reuters The 4th Research Front Award (2016). His research interests focus on the design and synthesis of functional (especially, biologically active) molecules.

 

Professor Kanai’s recent articles in OBC include:

5-Position-selective C–H trifluoromethylation of 8-aminoquinoline derivatives
Org. Biomol. Chem., 2016, 14, 8092-8100, Paper

Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp3)–H bonds in aliphatic alcohols
Org. Biomol. Chem., 2016, 14, 4378-4381, Communication

This article is part of the themed collection: 2016 Hot Articles in Organic and Biomolecular Chemistry

 

Find out more about Professor Kanai and his research on his lab’s webpage.

Submit your work for Professor Kanai to handle today.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Time to Publication 2016

At OBC, we know one thing important to our authors is getting a decision to them quickly after they’ve submitted to us. That is why we worked extremely hard in 2016 to make this incredible fast, again.

We are proud to announce that in 2016, Organic and Biomolecular Chemistry got the first decision to authors in 12 days for Communications and 18 days for Papers on average, based on articles sent for peer review.

Organic & Biomolecular Chemistry’s Publication Times for 2016

Our average time from submission to Final Article Publication in 2016 was only 34 days for Communications and 43 days for Papers. As well as this, if an author opted for our Accepted Manuscript option, the unedited version of their manuscript was online a week earlier!

We would like to thank our referees for sending us thorough reviews so quickly as we could not have done this without you. We will be celebrating our referees more in the coming months so make sure you check back on this page.

If you would like to submit to OBC for rapid consideration of your high-quality organic chemistry research please see our website.

 

Make sure you’re following us on Twitter (@OrgBiomolChem) and Facebook (@obc.journal)!

Stay up to date with the latest from Organic and Biomolecular Chemistry by signing up for our weekly e-mail alerts. Fill in the online form today at http://www.rsc.org/Publishing/Journals/forms/V5profile.asp

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)