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E-WiSPOC 16

European-Winter School on Physical Organic Chemistry (E-WiSPOC)

31st January – 5th February 2016, Bressanone, Italy


OBC is pleased to support the European-Winter School on Physical Organic Chemistry (E-WiSPOC) 2016.

The topic for 2016 is – Functional Surfaces in Chemistry and Biology.

Lectures will be speaking on a variety of subjects, including:

  • Francesco Zerbetto – Theoretical and computational chemistry (University of Bologna)
  • Maria Ramos – Computational biochemistry (University of Porto)
  • Maria Minunni – Surface plasmon resonance (University of Firenze)
  • Chris Hunter – Physical organic chemistry and biomolecular interactions (University of Cambridge)
  • Bart Ravoo – Biological and supramolecular system (University of Muenster )
  • Jurrian Huskens – Biomolecular adhesion and tissue engineering (University of Twente)
  • Alessandro Casnati – Bioorganic and supramolecular chemistry (University of Parma)
  • Zoltan Takats – Ambient mass spectrometry (Imperial College London)

The school,which is part of the cultural initiatives of the Organic Division of the Italian Chemical Society, is open to PhD students and post-docs.

For information visit the e-wispoc website: www.chimica.unipd.it/wispoc or write to: wispoc.chimica@unipd.it

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Heterocyclic and Synthesis Group postgraduate meeting prize winners

Congratulations to all the  prize winners at the Heterocyclic and Synthesis Group Postgraduate Meeting.

The symposium took place on the 10th September 2015. It provides an opportunity for final year PhD students to present talks and posters.

The winners were:

Patrick Brown (Best talk prize) – Biomimetic Synthesis of Dimeric Phenylethanoids

Lee Eccleshare (Best flash presentation prize) – A Novel, One-Pot, Multi-Component Synthesis of Fused 8-Membered Carbocycles

Catherine Holden (Best poster prize) – TheBenzyne Smiles Reaction: A Transition Metal Free Biaryl Synthesis

Patrick Brown

Lee Eccleshare

Catherine Holden

The prizes were presented by Dr Andrew Williams of Eli Lilly.

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Poster Prize winners at RSC Organic Division Poster Symposium 2015

Congratulations to all the Poster Prize winners at the RSC Organic Division Poster Symposium 2015.

©Royal Society of Chemistry / MPP Image Creation

We are pleased to present the prize to these winners:

First Prize – Hiroki Wada
(University of Nottingham)

Second Prize – Keith Andrews & Giacomo Crisenza
(University of Nottingham & University of Bristol)

Industry Prize – Joanna Sadler
(University of Strathclyde)

Participants Prize – Jorge Gonzalez
(University of Edinburgh)

Organised by the Royal Society of Chemistry, the symposium took place in London on the 30th November 2015.

The symposium provides a fantastic opportunity for final year organic chemistry PhD students to showcase their research and network with their peers, leading academics, and industrial chemists.

In the words of the winner:  “This event provided me a great opportunity not only to learn cutting edge organic chemistry and biochemistry, but also to network with academics and industrial researchers. I feel that the event showcases the shift from traditional small molecule medicinal chemistry to biologically and nature orientated chemistry, and it was really interesting to observe this and also to contribute to it.  It was an invaluable experience meeting and discussing my work and theirs with many world leading scientists.”  (Hiroki Wada)

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What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are the most read Organic & Biomolecular Chemistry articles in July, August and September 2015.

Linear and star-shaped pyrazine-containing acene dicarboximides with high electron-affinity
Jinjun Shao, Jingjing Chang and Chunyan Chi
DOI: 10.1039/C2OB25680K, Paper

Recent synthetic additions to the visible light photoredox catalysis toolbox
Ricardo A. Angnes, Zhou Li, Carlos Roque D. Correia and Gerald B. Hammond
DOI: 10.1039/C5OB01349F, Review Article

Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids
Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura and Takashi Kato
DOI: 10.1039/C4OB01796J, Review Article

Decarboxylative functionalization of cinnamic acids
Arun Jyoti Borah and Guobing Yan
DOI: 10.1039/C5OB00727E, Review Article

Design and synthesis of analogues of natural products
Martin E. Maier
DOI: 10.1039/C5OB00169B, Review Article

Anatomy of gold catalysts: facts and myths
Beatrice Ranieri, Imma Escofet and Antonio M. Echavarren
DOI: 10.1039/C5OB00736D, Review Article

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines
Sadhan Jana, Athira Ashokan, Shailesh Kumar, Ajay Verma and Sangit Kumar
DOI: 10.1039/C5OB01196E, Communication

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
DOI: 10.1039/C3OB41993B, Review Article

Enantioselective cooperative catalysis
Suleman M. Inamdar, Valmik S. Shinde and Nitin T. Patil
DOI: 10.1039/C5OB00986C, Review Article

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo
DOI: 10.1039/C4OB00843J, Review Article

(more…)

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Poster Prize Winners at Biorelevant Chemistry Symposium

Congratulations to the Poster Prize winners at the 9th Symposium on Biorelevant Chemistry.

We were please to present the prize to these winners:

  • Ayaka Nakashima (Nagoya University)
  • Kotaro Nishiyama (University of Tokyo)
  • Hayato Kawai (Nagoya University)
  • Takeya Shou (Tokyo Institute of Technology)
  • Takayuki Miki(Kyoto University

Organized by the Chemical Society of Japan, the Biorelevant Chemistry Symposium took place from 10-12th Sept in Kumamoto, Japan.

From left to right: Professor Rie Wakabayashi (Poster award committee co-chair), Professor Hiroyuki Asanuma (Poster award committee chair), Ayaka Nakashima, Kotaro Nishiyama , Hayato Kawai , Takeya Shou , Takayuki Miki, Professor Masahiro Takagi (Chair of the Division of Biotechnology, Chemical Society of Japan), Professor Itaru Hamachi (Vice-Chair of the Division of Biofunctional Chemistry, Chemical Society of Japan).

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Entry into Mitochondria to reveal oxidative secrets

Recently, researchers from The University of Sydney, under the leadership of Dr. Elizabeth New, have reported a novel redox probe that selectively localises in Mitochondria. This fluorescent probe, NpFR2, has been used to identify the variations in the oxidative capacity of the haematopoietic cells.

Targeting Mitochondria has become one of the most important research protocols due to its immense importance to organelle-specific drug delivery. Mitochondria, being the power house of a cell, are the focus of researchers working in the area. Similarly, reactive oxygen species (ROS) have a key role and their levels are important in maintaining the redox homeostasis of the cell. A number of biological processes have been linked to mitochondrial ROS levels. These include response to hypoxia, immune responses, cellular differentiation and maturation, autophagy and ageing.

Graphic 1Graphic 2

In this paper, Dr. Elizabeth New et al., presents this novel compound that can be used reversibly and has a reduction potential within the biologically relevant range. To target mitochondria, a triphenyl phosphonium (TPP) group is been incorporated into the molecule. Further, they test this molecule in haematopoietic cells and can identify the mitochondrial ROS levels of different types of cells such as bone marrow macrophages, thymus and spleen.

NpFR2 can further be combined with other fluorescent probes and antibodies for further understanding of mitochondrial ROS in different cell processes.

Find out more in their Communication:

Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells
Amandeep Kaur, Kurt W. L. Brigden, Timothy F. Cashman, Stuart T. Fraser and Elizabeth J. New
DOI: 10.1039/C5OB00928F

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Poster prize winners at ESOC

Congratulations to the Poster Prize winners at ESOC 2015.

The winners are:

  • Michael E. Muratore (OBC Best Oral Comm Prize) – “The versatility of gold(I) catalysis applied to the total synthesis of (-)-nardoaristolone B and lundurine C”
  • Joanna Wencel-Delord (OBC Poster Prize) – “Asymmetric C-H activation and dynamic kinetic resolution: new tool for the synthesis of axially chiral biaryls”
  • Szilár Varga (ChemComm Poster Prize) – “Organocatalytic approach to indole terpenoids”
  • Ana M. Matos (MedChemComm Poster Prize) – “Genista tenera as a source of new innovative molecular leads against diabetes and related amyloid disorders: phytochemistry, synthesis and mechanism of action”

The European Symposium of Organic Chemistry is a biannual event which is held all over Europe.  The 19th European Symposium of Organic Chemistry was held from 12th – 16th of July in Lisbon, at the Universidade de Lisboa.   The conference is aimed at stimulating new emerging areas in Organic Chemistry.

Photos of the winners below (from left to right): Michael E. Muratore, Joanna Wencel-Delord, Ana M. Matos and Szilár Varga.

Michael E. Muratore (OBC Best Oral Comm Prize) Joanna Wencel-Delord (OBC Poster Prize)
Ana M. Matos (MedChemComm Poster Prize) Szilár Varga (ChemComm Poster Prize)
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