Organic & Biomolecular Chemistry Blog

This month sees the following articles in OBC that are in the top ten most accessed:-

Carbohydrate chemistry in drug discovery 
M. Carmen Galan, David Benito-Alifonso and Gregory M. Watt 
Org. Biomol. Chem., 2011, 9, 3598-3610 DOI: 10.1039/C0OB01017K  

Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles 
Christopher L. Paradise, Pooja R. Sarkar, Mina Razzak and Jef K. De Brabander 
Org. Biomol. Chem., 2011, 9, 4017-4020 DOI: 10.1039/C1OB05390F 

Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives 
P. Ricardo Girling, Takao Kiyoi and Andrew Whiting 
Org. Biomol. Chem., 2011, 9, 3105-3121 DOI: 10.1039/C0OB00996B, Perspective 

The stimulating adventure of KRN 7000 
Aline Banchet-Cadeddu, Eric Hénon, Manuel Dauchez, Jean-Hugues Renault, Fanny Monneaux and Arnaud Haudrechy 
Org. Biomol. Chem., 2011, 9, 3080-3104 DOI: 10.1039/C0OB00975J  

Highly selective fluorescent OFF-ON thiol probes based on dyads of BODIPY and potent intramolecular electron sink 2,4-dinitrobenzenesulfonyl subunits 
Huimin Guo, Yingying Jing, Xiaolin Yuan, Shaomin Ji, Jianzhang Zhao, Xiaohuan Li and Yanyan Kan 
Org. Biomol. Chem., 2011, 9, 3844-3853 DOI: 10.1039/C0OB00910E 

Mild preparation of functionalized [2.2]paracyclophanes via the Pummerer rearrangement 
Matteo Montanari, Alberto Bugana, Arvind K. Sharma and Dario Pasini 
Org. Biomol. Chem., 2011, Advance Article DOI: 10.1039/C1OB05319A  

Rhodamine-based highly sensitive colorimetric off-on fluorescent chemosensor for Hg2+ in aqueous solution and for live cell imaging 
Hengguo Wang, Yapeng Li, Shufei Xu, Yanchun Li, Chen Zhou, Xiaoliang Fei, Lei Sun, Chaoqun Zhang, Yaoxian Li, Qingbiao Yang and Xiaoyi Xu 
Org. Biomol. Chem., 2011, 9, 2850-2855 DOI: 10.1039/C0OB01032D, Paper 

Energy transfer cassettes in silica nanoparticles target intracellular organelles 
Jiney Jose, Aurore Loudet, Yuichiro Ueno, Liangxing Wu, Hsiang-Yun Chen, Dong Hee Son, Rola Barhoumi, Robert Burghardt and Kevin Burgess 
Org. Biomol. Chem., 2011, 9, 3871-3877 DOI: 10.1039/C0OB00967A  

A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY 
Hui He and Dennis K. P. Ng 
Org. Biomol. Chem., 2011, 9, 2610-2613 DOI: 10.1039/C0OB01252A, Communication 

A specific chemodosimeter for fluoride ion based on a pyrene derivative with trimethylsilylethynyl groups 
Hua Lu, Qiuhong Wang, Zhifang Li, Guoqiao Lai, Jianxiong Jiang and Zhen Shen 
Org. Biomol. Chem., 2011, Advance Article DOI: 10.1039/C1OB05164D  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us your suggestions.
   

This month sees the following articles in OBC that are in the top ten most accessed:-

A facile method for the synthesis of oxindole based quaternary a-aminonitriles via the Strecker reaction 
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou 
Org. Biomol. Chem., 2010, 8, 3847-3850 DOI: 10.1039/C0OB00174K, Communication 

Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis 
Dhevalapally B. Ramachary and Sangeeta Jain 
Org. Biomol. Chem., 2011, 9, 1277-1300 DOI: 10.1039/C0OB00611D, Emerging Area 

Carbohydrate chemistry in drug discovery 
M. Carmen Galan, David Benito-Alifonso and Gregory M. Watt 
Org. Biomol. Chem., 2011, 9, 3598-3610 DOI: 10.1039/C0OB01017K, Perspective 

Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives 
P. Ricardo Girling, Takao Kiyoi and Andrew Whiting 
Org. Biomol. Chem., 2011, 9, 3105-3121 DOI: 10.1039/C0OB00996B, Perspective 

A general approach to high-yielding asymmetric synthesis of chiral 3-alkyl-4-nitromethylchromans via cascade Barbas-Michael and acetalization reactions 
Dhevalapally B. Ramachary, M. Shiva Prasad and R. Madhavachary 
Org. Biomol. Chem., 2011, 9, 2715-2721 DOI: 10.1039/C0OB00861C, Paper 

A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY 
Hui He and Dennis K. P. Ng 
Org. Biomol. Chem., 2011, 9, 2610-2613 DOI: 10.1039/C0OB01252A, Communication 

Cycloaddition of homochiral dihydroimidazoles: A 1,3-dipolar cycloaddition route to optically active pyrrolo[1,2-a]imidazoles 
Raymond C. F. Jones, Kevin J. Howard, John S. Snaith, Alexander J. Blake, Wang-Shei Li and Peter J. Steel 
Org. Biomol. Chem., 2011, 9, 297-306 DOI: 10.1039/C0OB00529K, Paper 

Rhodamine-based highly sensitive colorimetric off-on fluorescent chemosensor for Hg2+ in aqueous solution and for live cell imaging 
Hengguo Wang, Yapeng Li, Shufei Xu, Yanchun Li, Chen Zhou, Xiaoliang Fei, Lei Sun, Chaoqun Zhang, Yaoxian Li, Qingbiao Yang and Xiaoyi Xu 
Org. Biomol. Chem., 2011, 9, 2850-2855 DOI: 10.1039/C0OB01032D, Paper 

Chiral BINOL-derived phosphoric acids: privileged Brønsted acid organocatalysts for C-C bond formation reactions 
Alexandru Zamfir, Sebastian Schenker, Matthias Freund and Svetlana B. Tsogoeva 
Org. Biomol. Chem., 2010, 8, 5262-5276 DOI: 10.1039/C0OB00209G, Perspective 

Second-order NMR spectra at high field of common organic functional groups 
Paul J. Stevenson 
Org. Biomol. Chem., 2011, 9, 2078-2084 DOI: 10.1039/C0OB00705F, Comment 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in OBC that are in the top ten most accessed:- 

Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis 
Dhevalapally B. Ramachary and Sangeeta Jain 
Org. Biomol. Chem., 2011, 9, 1277-1300, DOI: 10.1039/C0OB00611D, Emerging Area 

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands 
David Deniaud, Karine Julienne and Sébastien G. Gouin 
Org. Biomol. Chem., 2011, 9, 966-979, DOI: 10.1039/C0OB00389A, Perspective 

Total synthesis of cyanolide A 
Zhen Yang, Xingang Xie, Peng Jing, Gaoyuan Zhao, Jiyue Zheng, Changgui Zhao and Xuegong She 
Org. Biomol. Chem., 2011, 9, 984-986, DOI: 10.1039/C0OB00971G, Communication 

Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides 
Pavel Starkov and Tom D. Sheppard 
Org. Biomol. Chem., 2011, 9, 1320-1323, DOI: 10.1039/C0OB01069C, Communication 

Synthesis of (1R,2R)-DPEN-derived triazolium salts and their application in asymmetric intramolecular Stetter reactions 
Min-Qiang Jia, Yi Li, Zi-Qiang Rong and Shu-Li You 
Org. Biomol. Chem., 2011, 9, 2072-2074, DOI: 10.1039/C1OB00025J, Communication 

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates 
Sabesan Yoganathan, Clarissa S. Sit and John C. Vederas 
Org. Biomol. Chem., 2011, 9, 2133-2141, DOI: 10.1039/C0OB00846J, Paper 

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells 
Mingming Hu, Jiangli Fan, Honglin Li, Kedong Song, Song Wang, Guanghui Cheng and Xiaojun Peng 
Org. Biomol. Chem., 2011, 9, 980-983, DOI: 10.1039/C0OB00957A, Communication 

A methionine-based turn-on chemical sensor for selectively monitoring Hg2+ ions in 100% aqueous solution 
Mi-Hwa Yang, Chuda Raj Lohani, Hyeongjin Cho and Keun-Hyeung Lee 
Org. Biomol. Chem., 2011, 9, 2350-2356, DOI: 10.1039/C0OB00780C, Paper 

Oxygen-promoted PdCl2-catalyzed ligand-free Suzuki reaction in aqueous media 
Chun Liu, Qijian Ni, Pingping Hu and Jieshan Qiu 
Org. Biomol. Chem., 2011, 9, 1054-1060, DOI: 10.1039/C0OB00524J, Paper 

Asymmetric organocatalytic Michael?a-amination sequence for the construction of a quaternary stereocenter 
Alaric Desmarchelier, Jérôme Marrot, Xavier Moreau and Christine Greck 
Org. Biomol. Chem., 2011, 9, 994-997, DOI: 10.1039/C0OB00751J, Communication 

Why not take a look at the articles today and blog your thoughts and comments below. Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us your suggestions.

This month sees the following articles in OBC that are in the top ten most accessed:-

A facile method for the synthesis of oxindole based quaternary a-aminonitriles via the Strecker reaction 
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou 
Org. Biomol. Chem., 2010, 8, 3847-3850, DOI: 10.1039/C0OB00174K, Communication 

Copper catalysis in the construction of indole and benzo[b]furan rings 
Sandro Cacchi, Giancarlo Fabrizi and Antonella Goggiamani 
Org. Biomol. Chem., 2011, 9, 641-652, DOI: 10.1039/C0OB00501K, Perspective 

Chiral BINOL-derived phosphoric acids: privileged Brønsted acid organocatalysts for C–C bond formation reactions
Alexandru Zamfir, Sebastian Schenker, Matthias Freund and Svetlana B. Tsogoeva 
Org. Biomol. Chem., 2010, 8, 5262-5276, DOI: 10.1039/C0OB00209G, Perspective 

Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides 
Pavel Starkov and Tom D. Sheppard 
Org. Biomol. Chem., 2011, 9, 1320-1323, DOI: 10.1039/C0OB01069C, Communication 

1,2-Sulfone rearrangement in organocatalytic reactions 
Adrien Quintard and Alexandre Alexakis 
Org. Biomol. Chem., 2011, 9, 1407-1418, DOI: 10.1039/C0OB00818D, Paper 

Reactions between Grignard reagents and heterocyclic N-oxides: Stereoselective synthesis of substituted pyridines, piperidines, and piperazines 
Hans Andersson, Roger Olsson and Fredrik Almqvist 
Org. Biomol. Chem., 2011, 9, 337-346, DOI: 10.1039/C0OB00336K, Perspective 

Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach 
Kavita De, Julien Legros, Benoit Crousse, Srinivasan Chandrasekaran and Danièle Bonnet-Delpon 
Org. Biomol. Chem., 2011, 9, 347-350, DOI: 10.1039/C0OB00496K, Communication 

Pd/Cu-catalyzed cascade Sonogashira coupling/cyclization reactions to highly substituted 3-formyl furans 
Jingyu Yang, Chengyu Wang, Xin Xie, Hongfeng Li, Ende Li and Yanzhong Li 
Org. Biomol. Chem., 2011, 9, 1342-1346, DOI: 10.1039/C0OB00985G, Communication 

Highly sensitive detection of saccharides under physiological conditions with click synthesized boronic acid-oligomer fluorophores 
Karimulla Mulla, Prateek Dongare, Ningzhang Zhou, Guang Chen, David W. Thompson and Yuming Zhao 
Org. Biomol. Chem., 2011, 9, 1332-1336, DOI: 10.1039/C0OB01003K, Communication 

Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy
Vincent Malnuit, Maria Duca and Rachid Benhida 
Org. Biomol. Chem., 2011, 9, 326-336, DOI: 10.1039/C0OB00418A, Perspective 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us  your suggestions.

This month sees the following articles in OBC that are in the top ten most accessed:-

A facile method for the synthesis of oxindole based quaternary a-aminonitriles via the Strecker reaction 
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou 
Org. Biomol. Chem., 2010, 8, 3847-3850, DOI: 10.1039/C0OB00174K, Communication 

Chiral Separation by Enantioselective Liquid-Liquid Extraction
Boelo Schuur, Bastiaan J. V. Verkuijl, Adriaan J. Minnaard, Johannes G. de Vries, Hero J. Heeres and Ben L. Feringa 
Org. Biomol. Chem., 2011, 9, 36-51, DOI: 10.1039/C0OB00610F, Perspective 

Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis 
Dhevalapally B. Ramachary and Sangeeta Jain 
Org. Biomol. Chem., 2011, Advance Article, DOI: 10.1039/C0OB00611D, Emerging Area 

Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter  
Alaric Desmarchelier, Jérôme Marrot, Xavier Moreau and Christine Greck 
Org. Biomol. Chem., 2011, Advance Article, DOI: 10.1039/C0OB00751J, Communication 

Oxidative amide synthesis directly from alcohols with amines 
Cheng Chen and Soon Hyeok Hong 
Org. Biomol. Chem., 2011, 9, 20-26, DOI: 10.1039/C0OB00342E, Emerging Area 

Copper catalysis in the construction of indole and benzo[b]furan rings 
Sandro Cacchi, Giancarlo Fabrizi and Antonella Goggiamani 
Org. Biomol. Chem., 2011, 9, 641-652, DOI: 10.1039/C0OB00501K, Perspective 

Efficient total synthesis of (-)-stemoamide 
Toshio Honda, Tomoha Matsukawa and Kazunori Takahashi 
Org. Biomol. Chem., 2011, 9, 673-675, DOI: 10.1039/C0OB00850H, Communication 

Synthesis of difluoroaryldioxoles using BrF3 
Youlia Hagooly, Michael J. Welch and Shlomo Rozen
Org. Biomol. Chem., 2011, 9, 902-905, DOI: 10.1039/C0OB00571A, Paper 

Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes 
Mohosin Layek, Appi Reddy M., A. V. Dhanunjaya Rao, Mallika Alvala, M. K. Arunasree, Aminul Islam, K. Mukkanti, Javed Iqbal and Manojit Pal 
Org. Biomol. Chem., 2011, Advance Article, DOI: 10.1039/C0OB00771D, Communication 

Practical access to highly enantioenriched quaternary carbon Michael adducts using simple organocatalysts 
Thomas C. Nugent, Mohammad Shoaib and Amna Shoaib 
Org. Biomol. Chem., 2011, 9, 52-56, DOI: 10.1039/C0OB00822B, Communication 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us your suggestions.