Author Archive

Recent HOT Organic & Biomolecular Chemistry articles

Check out the following HOT articles, these have been made free to access for a limited time:

Synthesis and immunological effects of heroin vaccines
Fuying Li, Kejun Cheng, Joshua F. G. Antoline, Malliga R. Iyer, Gary R. Matyas, Oscar B. Torres, Rashmi Jalah, Zoltan Beck, Carl R. Alving, Damon A. Parrish, Jeffrey R. Deschamps, Arthur E. Jacobson and Kenner C. Rice
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01053A

Synthesis and immunological effects of heroin vaccines

Free to access until 21st August 2014


6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures
Giampiero D’Adamio, Camilla Parmeggiani, Andrea Goti, Antonio J. Moreno-Vargas, Elena Moreno-Clavijo, Inmaculada Robina and Francesca Cardona
Org. Biomol. Chem., 2014,12, 6250-6266
DOI: 10.1039/C4OB01117A

6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures

Free to access until 21st August 2014


Relative contractile motion of the rings in a switchable palindromic [3]rotaxane in aqueous solution driven by radical-pairing interactions
Leah S. Witus, Karel J. Hartlieb, Yuping Wang, Aleksandrs Prokofjevs, Marco Frasconi, Jonathan C. Barnes, Edward J. Dale, Albert C. Fahrenbach and J. Fraser Stoddart
Org. Biomol. Chem., 2014,12, 6089-6093
DOI: 10.1039/C4OB01228C

Relative contractile motion of the rings in a switchable palindromic [3]rotaxane in aqueous solution driven by radical-pairing interactions

Free to access until 21st August 2014


Catalytic control over the formation of supramolecular materials
Rienk Eelkema and Jan H. van Esch
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01108B

Catalytic control over the formation of supramolecular materials

Free to access until 21st August 2014


Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik, Luc Henry, Michael A. McDonough, Timothy D. W. Claridge and Christopher J. Schofield
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01167H

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

Free to access until 21st August 2014


Diaporine, a novel endophyte-derived regulator of macrophage differentiation
Hao Chen Wu, Hui Ming Ge, Le Yun Zang, Yun Cheng Bei, Zhi Yuan Niu, Wei Wei, Xiu Jing Feng, Sen Ding, Seik Weng Ng, Ping Ping Shen and Ren Xiang Tan
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01123F

Diaporine, a novel endophyte-derived regulator of macrophage differentiation

Free to access until 21st August 2014


New reagents for detecting free radicals and oxidative stress
Mina Barzegar Amiri Olia, Carl H. Schiesser and Michelle K. Taylor
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01172D

New reagents for detecting free radicals and oxidative stress

Free to access until 21st August 2014

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Recent HOT Organic & Biomolecular Chemistry articles

Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis
Lara Cala, Francisco J. Fañanás and Félix Rodríguez  
Org. Biomol. Chem., 2014,12, 5324-5330
DOI: 10.1039/C4OB00737A

Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

Free to access until 1st August 2014


Multivalent glycosylated nanoparticles for studying carbohydrate–protein interactions
Avijit K. Adak, Hong-Jyune Lin and Chun-Cheng Lin
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00827H

Multivalent glycosylated nanoparticles for studying carbohydrate–protein interactions

Free to access until 1st August 2014


A simple approach to pyrrolylimidazole derivatives by azirine ring expansion with imidazolium ylides
Alexander F. Khlebnikov, Olesya A. Tomashenko, Liya D. Funt and Mikhail S. Novikov  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00865K

A simple approach to pyrrolylimidazole derivatives by azirine ring expansion with imidazolium ylides

Free to access until 1st August 2014


Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B
Jeffrey Buter, Renée Moezelaar and Adriaan J. Minnaard  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01085J

Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

Free to access until 1st August 2014


Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection
B. D. Reeves, N. Joshi, G. C. Campanello, J. K. Hilmer, L. Chetia, J. A. Vance, J. N. Reinschmidt, C. G. Miller, D. P. Giedroc, E. A. Dratz, D. J. Singel and P. A. Grieco  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00995A

Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection

Free to access until 1st August 2014


A tryptophan responsive fluorescent and wettable dual-signal switch
Xiaoyan Zhang, Jing Li, Ningmei Feng, Li Luo, Zhen Dai, Li Yang, Demei Tian and Haibing Li
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00792A

A tryptophan responsive fluorescent and wettable dual-signal switch

Free to access until 1st August 2014

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Recent HOT Organic & Biomolecular Chemistry articles

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress
Ayumi Tsutsui, Rie Imamaki, Shinobu Kitazume, Shinya Hanashima, Yoshiki Yamaguchi, Masato Kaneda, Shinya Oishi, Nobutaka Fujii, Almira Kurbangalieva, Naoyuki Taniguchi and Katsunori Tanaka  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00761A

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress

Free to access until 18th July 2014


Catalytic functionalization of tertiary alcohols to fully substituted carbon centres
Long Chen, Xiao-Ping Yin, Cui-Hong Wang and Jian Zhou
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00718B

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

Free to access until 18th July 2014


Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners
Wei Lu, Yang Li, Chao Wang, Dong Xue, Jian-Gang Chen and Jianliang Xiao
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00568F

Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners

Free to access until 18th July 2014


Asymmetric synthesis of substituted NH-piperidines from chiral amines
Lekh Nath Gautam, Yijin Su, Novruz G. Akhmedov, Jeffrey L. Petersen and Xiaodong Shi  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00657G

Asymmetric synthesis of substituted NH-piperidines from chiral amines

Free to access until 18th July 2014


Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers
Hazit Zayas, Clovia I. Holdsworth, Michael C. Bowyer and Adam McCluskey  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00517A

Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers

Free to access until 18th July 2014


Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters
Yu-Juan Guo, Pei-Jiang Chen, Bo Wang and Ai-Yun Peng  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00663A

Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters

Free to access until 18th July 2014


In(OTf)3-catalysed one-pot versatile pyrrole synthesis through domino annulation of α-oxoketene-N,S-acetals with nitroolefins
Abhijeet Srivastava, Gaurav Shukla, Anugula Nagaraju, Girijesh Kumar Verma, Keshav Raghuvanshi, Raymond C. F. Jones and Maya Shankar Singh  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00781F

In(OTf)3-catalysed one-pot versatile pyrrole synthesis through domino annulation of α-oxoketene-N,S-acetals with nitroolefins

 

Free to access until 18th July 2014


Improving alkynyl(aryl)iodonium salts: 2-anisyl as a superior aryl group
David J. Hamnett and Wesley J. Moran  
Org. Biomol. Chem., 2014,12, 4156-4162
DOI: 10.1039/C4OB00556B

Graphical abstract

Free to access until 4th July 2014


Recent development of two-photon fluorescent probes for bioimaging
Dokyoung Kim, Hye Gun Ryu and Kyo Han Ahn
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00431K

Graphical abstract

Free to access until 4th July 2014


A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5
Karunakaran A. Kalesh and Edward W. Tate  
Org. Biomol. Chem., 2014,12, 4310-4313
DOI: 10.1039/C4OB00773E

Graphical abstract 

Free to access until 4th July 2014


Marine bacteria from the Roseobacter clade produce sulfur volatiles via amino acid and dimethylsulfoniopropionate catabolism
Nelson L. Brock, Markus Menke, Tim A. Klapschinski and Jeroen S. Dickschat  
Org. Biomol. Chem., 2014,12, 4318-4323
DOI: 10.1039/C4OB00719K

Graphical abstract

Free to access until 4th July 2014


Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines
Stephen G. Davies, Ai M. Fletcher and James E. Thomson  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00616J

Graphical abstract

Free to access until 4th July 2014


An intracellularly activatable, fluorogenic probe for cancer imaging
Ruisong Tian, Mingjie Li, Jin Wang, Min Yu, Xiuqi Kong, Yupeng Feng, Zeming Chen, Yuxi Li, Weiqiang Huang, Wenjie Wu and Zhangyong Hong  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00297K

Graphical abstract

Free to access until 4th July 2014


Palladium mediated intramolecular multiple C–X/C–H cross coupling and C–H activation: synthesis of carbazole alkaloids calothrixin B and murrayaquinone A
Srinivasan A. Kaliyaperumal, Shyamapada Banerjee and Syam Kumar U. K.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00493K

Graphical abstract

Free to access until 4th July 2014

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Q1 Top Ten most accessed Organic & Biomolecular Chemistry articles

During January, February and March this year, the following articles were the Top Ten most accessed:

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry
Karunakaran A. Kalesh, Kai Liu and Shao Q. Yao  
Org. Biomol. Chem., 2009,7, 5129-5136
DOI: 10.1039/b913333j

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva  
Org. Biomol. Chem., 2013,11, 7051-7071
DOI: 10.1039/c3ob41403e

Copper-catalyzed highly efficient ester formation from carboxylic acids/esters and formates
Jun Liu, Changdong Shao, Yanghui Zhang, Guangfa Shi and Shulei Pan
Org. Biomol. Chem., 2014,12, 2637-2640
DOI: 10.1039/c4ob00193a

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei  
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/c3ob40137e

Recent progress towards transition metal-catalyzed synthesis of y-lactams
Long-Wu Ye, Chao Shu and Fabien Gagosz  
Org. Biomol. Chem., 2014,12, 1833-1845
DOI: 10.1039/c3ob42181c

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
Org. Biomol. Chem., 2014,12, 212-232
DOI: 10.1039/c3ob41993b

KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water
Yuyu Gao, Qiuling Song, Guolin Cheng and Xiuling Cui  
Org. Biomol. Chem., 2014,12, 1044-1047
DOI: 10.1039/c3ob42318b

A biocompatible, highly efficient click reaction and its applications
Yue Yuan and Gaolin Liang  
Org. Biomol. Chem., 2014,12, 865-871
DOI: 10.1039/c3ob41241e

“Frustrated Lewis pairs”: a concept for new reactivity and catalysis
Douglas W. Stephan  
Org. Biomol. Chem., 2008,6, 1535-1539
DOI: 10.1039/b802575b

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry
Erik L. Regalado, Marisa C. Kozlowski, John M. Curto, Tobias Ritter, Michael G. Campbell, Anthony R. Mazzotti, Bruce C. Hamper, Christopher D. Spilling, Michael P. Mannino, Li Wan, Jin-Quan Yu, Jinchu Liu and Christopher J. Welch  
Org. Biomol. Chem., 2014,12, 2161-2166
DOI: 10.1039/c3ob42195c

Please post your comments or thoughts on any of these articles in the comment box below.

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Recent HOT articles for Organic & Biomolecular Chemistry

“Click and go”: simple and fast folic acid conjugation
Alexandre F. Trindade, Raquel F. M. Frade, Ermelinda M. S. Maçôas, Cátia Graça, Catarina A. B. Rodrigues, José M. G. Martinho and Carlos A. M. Afonso
Org. Biomol. Chem., 2014,12, 3181-3190
DOI: 10.1039/C4OB00150H 

“Click and go”: simple and fast folic acid conjugation 


 Cooperative hydrolysis of aryl esters on functionalized membrane surfaces and in micellar solutions
M. Poznik and B. König  
Org. Biomol. Chem., 2014,12, 3175-3180
DOI: 10.1039/C4OB00247D 

Cooperative hydrolysis of aryl esters on functionalized membrane surfaces and in micellar solutions 


Synthesis of new anionic carbosilane dendrimers via thiol–ene chemistry and their antiviral behaviour
Marta Galán, Javier Sánchez Rodríguez, José Luis Jiménez, Miguel Relloso, Marek Maly, F. Javier de la Mata, M. A. Muñoz-Fernández and Rafael Gómez  
Org. Biomol. Chem., 2014,12, 3222-3237
DOI: 10.1039/C4OB00162A 

Synthesis of new anionic carbosilane dendrimers via thiol–ene chemistry and their antiviral behaviour 


Strategies for the construction of tetrahydropyran rings in the synthesis of natural products
Nadiah Mad Nasir, Kristaps Ermanis and Paul A. Clarke
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00423J 

Strategies for the construction of tetrahydropyran rings in the synthesis of natural products


Cyclodextrin ion channels
Jonathan K. W. Chui and T. M. Fyles  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00480A 

Cyclodextrin ion channels


Bis-chlorination of a hexapeptide–PCP conjugate by the halogenase involved in vancomycin biosynthesis
Patrick C. Schmartz, Katja Zerbe, Khaled Abou-Hadeed and John A. Robinson  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00474D 

Bis-chlorination of a hexapeptide–PCP conjugate by the halogenase involved in vancomycin biosynthesis


An easy arylation of 2-substituted 1,2,3-triazoles
Suping Shi, Wei Liu, Ping He and Chunxiang Kuang  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00530A

An easy arylation of 2-substituted 1,2,3-triazoles


Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
Jan Hartwig, Jan B. Metternich, Nikzad Nikbin, Andreas Kirschning and Steven V. Ley
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00662C

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns


Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging
Yong Ni and Jishan Wu
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42554A

Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging


Phosphate esters and anhydrides – recent strategies targeting nature’s favoured modifications
Henning J. Jessen, Nisar Ahmed and Alexandre Hofer
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00478G

Phosphate esters and anhydrides – recent strategies targeting nature's favoured modifications


sp3 C–H oxidation by remote H-radical shift with oxygen- and nitrogen-radicals: a recent update
Shunsuke Chiba and Hui Chen
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00469H

sp3 C–H oxidation by remote H-radical shift with oxygen- and nitrogen-radicals: a recent update


A facile and convenient sequential homobimetallic catalytic approach towards ß-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy
Sebastián O. Simonetti, Enrique L. Larghi and Teodoro S. Kaufman
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00604F

A facile and convenient sequential homobimetallic catalytic approach towards ß-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy


An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones
Arun K. Ghosh and Zhi-Hua Chen
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00511B

An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones


Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of ß-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols
Elizabeth V. Crabtree, R. Fernando Martínez, Shinpei Nakagawa, Isao Adachi, Terry D. Butters, Atsushi Kato, George W. J. Fleet and Andreas F. G. Glawar  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00097H

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of ß-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols


Preparation of functionalized heteroaromatics using an intramolecular Wittig reaction
Utpal Das, Yi-Ling Tsai and Wenwei Lin
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00464G

Preparation of functionalized heteroaromatics using an intramolecular Wittig reaction


Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes
Kazutada Ikeuchi, Ryosuke Fujii, Shimpei Sugiyama, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Jae-Hoon Choi, Tomohiro Suzuki, Hirokazu Kawagishi and Toshiyuki Kan  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00705K

Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes

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Celebrating Ian Paterson’s 60th Birthday

In May 2014, Ian Paterson celebrates his sixtieth birthday. Eighty students have completed PhDs under his guidance. To mark this milestone, the RSC are collating the papers he has published in RSC journals and making them available to everybody. Ian was born in Dundee, and studied at St Andrew’s University. Two papers were published in the Journal of the Chemical Society as a result of his undergraduate research. He then moved to the University of Cambridge to work with Ian Fleming and to contribute further to RSC publications. A postdoctoral fellowship at Columbia University followed, working with Gilbert Stork, who had published fewer papers with the RSC than Ian. Ian then returned to the UK, first to UCL and then to Cambridge, where he has been for the last three decades.He has developed new methods for stereoselective transformations, particularly the boron-mediated aldol reaction, and used these in the syntheses of larger and larger molecules with increasing stereochemical complexity. The first report of his approach to discodermolide appeared in Chem Comm (1993) and, in due course, the synthesis was scaled up so that it could be used for clinical development. Studies on spongistatin, spirastrellolide, dictyostatin and other complex natural products have all been reported in RSC journals, as well as investigations of hybrids and semi-synthetic analogues. Ian has been elected to fellowships both of the Royal Society and the Royal Society of Edinburgh, and has won many RSC prizes including the Meldola Prize (1983), Hickinbottom Fellowship (1989), Bader Award (1996), Synthetic Organic Chemistry Award (2001), and the Tilden Prize (2009).Professor Jonathan Goodman
University of Cambridge, UK

All articles are free to access until 13th June 2014

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim and Philip Maltas
Org. Biomol. Chem., 2012,10, 5873-5886, DOI: 10.1039/C2OB25101A 

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas, Olivier Loiseleur, Julien Genovino and Christian Moessner  
Org. Biomol. Chem., 2012,10, 5861-5872, DOI: 10.1039/C2OB25100K

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues
A. Jonathan Singh, Mina Razzak, Paul Teesdale-Spittle, Thomas N. Gaitanos, Anja Wilmes, Ian Paterson, Jonathan M. Goodman, John H. Miller and Peter T. Northcote  
Org. Biomol. Chem., 2011,9, 4456-4466, DOI: 10.1039/C0OB01127D 

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
Ian Paterson, Guy J. Naylor, Takeshi Fujita, Esther Guzmán and Amy E. Wright  
Chem. Commun., 2010,46, 261-263, DOI: 10.1039/B921237J

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Synthesis and stereochemical determination of the spirastrellolides
Ian Paterson and Stephen M. Dalby  
Nat. Prod. Rep., 2009,26, 865-873, DOI: 10.1039/B906991G

Synthesis and stereochemical determination of the spirastrellolides

Total synthesis of (-)-spirangien A and its methylester
Ian Paterson, Alison D. Findlay and Christian Noti  
Chem. Commun., 2008, 6408-6410, DOI: 10.1039/B816229H

Total synthesis of the marine macrolide (+)-neopeltolide
Ian Paterson and Natalie A. Miller
Chem. Commun., 2008, 4708-4710, DOI: 10.1039/B812914B

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide
Ian Paterson, Guy J. Naylor and Amy E. Wright
Chem. Commun., 2008, 4628-4630, DOI: 10.1039/B811575C

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
Gordon J. Florence, Nicola M. Gardner and Ian Paterson  
Nat. Prod. Rep., 2008,25, 342-375, DOI: 10.1039/B705661N

Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Julien Genovino, Jong Ho Lim and Christian Moessner  
Chem. Commun., 2007, 1852-1854, DOI: 10.1039/B700827A

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
Ian Paterson and Nicola M. Gardner
Chem. Commun., 2007, 49-51, DOI: 10.1039/B615122A

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas and Christian Moessner
Chem. Commun., 2006, 4186-4188, DOI: 10.1039/B612697A

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support
Ian Paterson, Dirk Gottschling and Dirk Menche  
Chem. Commun., 2005, 3568-3570, DOI: 10.1039/B505746A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Karl R. Gibson and Debra J. Wallace  
Org. Biomol. Chem., 2005,3, 2410-2419, DOI: 10.1039/B504148A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Renata M. Oballa, Debra J. Wallace and Roger D. Norcross  
Org. Biomol. Chem., 2005,3, 2399-2409, DOI: 10.1039/B504146E

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Ian Paterson, David Y.-K. Chen, Mark J. Coster, José L. Aceña, Jordi Bach and Debra J. Wallace
Org. Biomol. Chem., 2005,3, 2431-2440, DOI: 10.1039/B504151A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, José L. Aceña, Jordi Bach, Linda E. Keown and Thomas Trieselmann  
Org. Biomol. Chem., 2005,3, 2420-2430, DOI: 10.1039/B504149J

Phorboxazole B synthetic studies: construction of C(1–32) and C(33–46) subtargets
Ian Paterson, Alan Steven and Chris A. Luckhurst  
Org. Biomol. Chem., 2004,2, 3026-3038, DOI: 10.1039/B407240E

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Ian Paterson, Robert Britton, Oscar Delgado and Amy E. Wright  
Chem. Commun., 2004, 632-633, DOI: 10.1039/B316390C

Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation
Ian Paterson, Jose L. Aceña, Jordi Bach, David Y.-K. Chen and Mark J. Coster  
Chem. Commun., 2003, 462-463, DOI: 10.1039/B212651F

Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S )-1-(benzyloxy)-2-methylpentan-3-one, and conformational aspects of extended polypropionates
Ian Paterson and Jeremy P. Scott  
J. Chem. Soc., Perkin Trans. 1, 1999, 1003-1014, DOI: 10.1039/A809818B

Recent developments in asymmetric aldol methodology
Alison S. Franklin and Ian Paterson  
Contemp. Org. Synth., 1994,1, 317-338, DOI: 10.1039/CO9940100317

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8d-lactone subunit
Ian Paterson and Stephen P. Wren  
J. Chem. Soc., Chem. Commun., 1993, 1790-1792, DOI: 10.1039/C39930001790

The formation of allyl sulphides by phenylthio-migration: control by silicon
Ian Fleming, Ian Paterson and Andrew Pearce
J. Chem. Soc., Perkin Trans. 1, 1981, 256-262, DOI: 10.1039/P19810000256

Free radical addition to olefins. Part 23. Kinetics of the addition of chloroiodomethane to ethylene and vinyl fluoride
Ian Paterson, John M. Tedder and John C. Walton  
J. Chem. Soc., Perkin Trans. 2, 1978, 884-887, DOI: 10.1039/P29780000884

Homosolvolysis
Hamish Low, Ian Paterson, John M. Tedder and John Walton  
J. Chem. Soc., Chem. Commun., 1977, 171-172, DOI: 10.1039/C39770000171

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Q4 Top Ten most accessed Organic & Biomolecular Chemistry articles

During October, November and December, the following articles were the Top Ten most accessed:

A coumarin-based fluorescent probe for biological thiols and its application for living cell imaging
Lingliang Long, Liping Zhou, Lin Wang, Suci Meng, Aihua Gong, Fengyi Du and Chi Zhang
Org. Biomol. Chem., 2013,11, 8214-8220
DOI: 10.1039/c3ob41741g; Download PDF

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva
Org. Biomol. Chem., 2013,11, 7051-7071
DOI: 10.1039/c3ob41403e; Download PDF

To be or not to be metal-free: trends and advances in coupling chemistries
Rick Arneil D. Arancon, Carol Sze Ki Lin, Carolina Vargas and Rafael Luque
Org. Biomol. Chem., 2014,12, 10-35
DOI: 10.1039/c3ob41768a; Download PDF

Synthetic applications of arylboronic acid via an aryl radical transfer pathway
Guobing Yan, Minghua Yang and Xiangmei Wu
Org. Biomol. Chem., 2013,11, 7999-8008
DOI: 10.1039/c3ob41851k; Download PDF

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/c3ob40137e; Download PDF

Analysis of the reactions used for the preparation of drug candidate molecules
John S. Carey, David Laffan, Colin Thomson and Mike T. Williams
Org. Biomol. Chem., 2006,4, 2337-2347
DOI: 10.1039/b602413k; Download PDF

N-heterocyclic carbene-catalyzed reactions of C–C unsaturated bonds
Xiang-Yu Chen and Song Ye
Org. Biomol. Chem., 2013,11, 7991-7998
DOI: 10.1039/c3ob41469h; Download PDF

Copper-catalyzed redox-neutral C–H amination with amidoximes
Hui Chen and Shunsuke Chiba
Org. Biomol. Chem., 2014,12, 42-46
DOI: 10.1039/c3ob41871e; Download PDF

Recent trends in Pd-catalyzed remote functionalization of carbonyl compounds
Ivan Franzoni and Clément Mazet
Org. Biomol. Chem., 2014,12, 233-241
DOI: 10.1039/c3ob42050g; Download PDF

Maximising multivalency effects in protein–carbohydrate interactions
Roland J. Pieters
Org. Biomol. Chem., 2009,7, 2013-2025
DOI: 10.1039/b901828j; Download PDF

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HOT Organic & Biomolecular Chemistry articles for January

A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate–isothiocyanate conversion in aqueous ethanol
Suman Pal, Joydev Hatai, Mousumi Samanta, Alok Shaurya and Subhajit Bandyopadhyay  
Org. Biomol. Chem., 2014,12, 1072-1078
DOI: 10.1039/C3OB42108B

 Graphical abstract


Ethynylbenzenoid metabolites of Antrodia camphorata: synthesis and inhibition of TNF expression
Marco Buccini, Kathryn A. Punch, Belinda Kaskow, Gavin R. Flematti, Brian W. Skelton, Lawrence J. Abraham and Matthew J. Piggott  
Org. Biomol. Chem., 2014,12, 1100-1113
DOI: 10.1039/C3OB42333F

Free to access until 21st February 2014

Graphical abstract


Hypervalent iodine(III)-mediated cyclopropa(e)nation of alkenes/alkynes under mild conditions
Shaoxia Lin, Mengru Li, Zhiyong Dong, Fushun Liang and Jingping Zhang  
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42123F

Free to access until 21st February 2014

Graphical abstract

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HOT Organic & Biomolecular Chemistry articles for December

Chiral amides via copper-catalysed enantioselective conjugate addition
Anne K. Schoonen, M. Ángeles Fernández-Ibáñez, Martín Fañanás-Mastral, Johannes F. Teichert and Ben L. Feringa  
Org. Biomol. Chem., 2014,12, 36-41, DOI: 10.1039/C3OB41923A 

Free to access until 16th January 2014

Chiral amides via copper-catalysed enantioselective conjugate addition

  


 Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding
Cally J. E. Haynes, Nathalie Busschaert, Isabelle L. Kirby, Julie Herniman, Mark E. Light, Neil J. Wells, Igor Marques, Vítor Félix and Philip A. Gale  
Org. Biomol. Chem., 2014,12, 62-72, DOI: 10.1039/C3OB41522H 

Free to access until 16th January 2014

Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding

  


 

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis  
Org. Biomol. Chem., 2014,12, 212-232, DOI: 10.1039/C3OB41993B   

Free to access until 16th January 2014

Synthesis of substituted pyrenes by indirect methods

  

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Q3 Top Ten most accessed Organic & Biomolecular Chemistry articles

During July, August and September, the following articles were the Top Ten most accessed:

Synthesis of azetidines and pyrrolidines via iodocyclisation of homoallyl amines and exploration of activity in a zebrafish embryo assay
Antonio Feula, Sundeep S. Dhillon, Rama Byravan, Mandeep Sangha, Ronald Ebanks, Mariwan A. Hama Salih, Neil Spencer, Louise Male, Istvan Magyary, Wei-Ping Deng, Ferenc Müller and John S. Fossey
Org. Biomol. Chem., 2013, 11, 5083-5093
DOI: 10.1039/c3ob41007b

Electrophilicity: the “dark-side” of indole chemistry
Marco Bandini
Org. Biomol. Chem., 2013, 11, 5206-5212
DOI: 10.1039/c3ob40735g

Transition-metal-catalyzed additions of C–H bonds to C–X (X = N, O) multiple bonds via C–H bond activation
Guobing Yan, Xiangmei Wu and Minghua Yang
Org. Biomol. Chem., 2013, 11, 5558-5578
DOI: 10.1039/c3ob40652k

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei  
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/C3OB40137E

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods
Marjoke F. Debets, Jan C. M. van Hest and Floris P. J. T. Rutjes  
Org. Biomol. Chem., 2013,11, 6439-6455
DOI: 10.1039/C3OB41329B

DABCO-promoted synthesis of pyrazoles from tosylhydrazones and nitroalkenes
Meng Tang, Wen Zhang and Yuanfang Kong  
Org. Biomol. Chem., 2013,11, 6250-6254
DOI: 10.1039/C3OB41435C

Organocatalytic asymmetric synthesis of ß3-amino acid derivatives
Sun Min Kim and Jung Woon Yang
Org. Biomol. Chem., 2013, 11, 4737-4749
DOI: 10.1039/c3ob40917a

The first asymmetric total synthesis of (+)-coriandrone A and B
Wenjing Wang, Jijun Xue, Tian Tian, Yingdong Jiao and Ying Li  
Org. Biomol. Chem., 2013,11, 6686-6690
DOI: 10.1039/C3OB41497C

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma
Kai Liu, Datong Zhang, Jeremy Chojnacki, Yuhong Du, Haian Fu, Steven Grant and Shijun Zhang  
Org. Biomol. Chem., 2013,11, 4757-4763
DOI: 10.1039/C3OB40595H

Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions
Dan Zhao, Min-Xue Zhu, Yue Wang, Qi Shen and Jian-Xin Li  
Org. Biomol. Chem., 2013,11, 6246-6249
DOI: 10.1039/C3OB41488D

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