In this HOT OBC paper from the ‘Nucleic acids: new life, new materials’ web collection, short and high-yielding syntheses for the nucleobases preQ1 base, Q base, and (ent)-Q base are described based on cheap and readily available starting compounds. For the latter two bases, Hans-Dieter Gerber and Gerhard Klebe use preQ1 as a central synthon and nucleophilic substitution reactions with appropriately decorated halocyclopentenyl synthons to produce the desired bases.
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Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base
Hans-Dieter Gerber and Gerhard Klebe
DOI: 10.1039/C2OB26387D
Liked that? Then why not have a look at the rest of the ‘Nucleic acids: new life, new materials’ web collection.
