Tanabe, Nishimoto and co-workers at Kyoto University, propose a mechanism for the intramolecular cyclization of modified oligodeoxynucleotides bearing a pair of disulfides.
This colourful cover represents how X-Ray irradiation of an aqueous solution of modified oligodeoxynucleotides with a pair of disulfides at both ends causes efficient cyclization via an
intramolecular exchange reaction.
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Radiolytic cyclization of stem-and-loop structured oligodeoxynucleotide with neighboring arrangement of α,ω-bis-disulfides
Kazuhito Tanabe, Eiji Matsumoto, Takeo Ito and Sei-ichi Nishimoto
Org. Biomol. Chem., 2010, 8, 4837-4842
DOI: 10.1039/C0OB00275E