M. Belén Cid et al. at the Universidad Autonoma de Madrid, Spain, have devised a simple and efficient organocatalytic approach for the synthesis of alpha-aryl cyclohexenones and cyclohexanones, leading to ee up to 96% and complete diastereoselectivity, via a Michael addition and aldol reaction as key steps.
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An organocatalytic approach to enantiomerically enriched α-arylcyclohexenones and cyclohexanones
Sara Duce, María Jorge, Inés Alonso, José Luis García Ruano and M. Belén Cid
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB06356A, Paper
From collection Organocatalysis
