Archive for March, 2013

HOT-2,4-Disubstituted thiazole derivatives as small molecule modulators of cellular development

In this HOT paper, Marder, Whiting, Przyborski and co-workers investigate the ability of thiazole-containing small molecules to induce the differentiation of human pluripotent stem cells and their derivatives. Understanding how the structure of molecules relates to their function and biological activity is essential in the development of new analogues with targeted activity. This is especially relevant in mediating developmental processes in mammalian cells and the regulation of stem cell differentiation. This study provides further insight into the complexity of compound design in terms of developing small molecules with specific biological activities to control the development and differentiation of mammalian cells.

Synthesis and applications of 2,4-disubstituted thiazole derivatives as small molecule modulators of cellular development
Garr-Layy Zhou, Daniel M. Tams, Todd B. Marder, Roy Valentine, Andrew Whiting and Stefan A. Przyborski
DOI: 10.1039/C3OB00005B

Free to access for 4 weeks

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March’s HOT articles

These articles are HOT as recommended by the referees. And we’ve made them free to access for 4 weeks.

Host–guest complexation driven dynamic supramolecular self-assembly
 
Huacheng Zhang, Kim Truc Nguyen, Xing Ma, Hong Yan, Junfei Guo, Liangliang Zhu and Yanli Zhao

Org. Biomol. Chem.
, 2013, DOI: 10.1039/C2OB27340C

Free to access untill 11th April

 
Mario Altendorfer, Aruna Raja, Florenz Sasse, Herbert Irschik and Dirk Menche

Org. Biomol. Chem.
, 2013, DOI: 10.1039/C2OB26906F
Free to access untill 11th April

 

 

 

 

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