In this HOT article, Rao and co-workers report a novel Rh(II) and Ru(II) catalysed regio- and chemoselective C-H oxygenation for the facile synthesis of a variety of functionalised phenols from easily accessible arenes. The reaction demonstrates excellent reactivity, ortho-selectivity, good functional group tolerance and high yields. This practical method allowed the synthesis of a few 2-acylphenols in gram-scale and its utility has been well exemplified in further applications in heterocycle synthesis and direct modification of drug Fenofibrate.
Broadening the catalyst and reaction scope of region- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis
Gang Shan, Xuesong Han, Yun Lin, Shanyou Yu and Yu Rao
DOI: 10.1039/C3OB27457H
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