In this HOT paper, Marder, Whiting, Przyborski and co-workers investigate the ability of thiazole-containing small molecules to induce the differentiation of human pluripotent stem cells and their derivatives. Understanding how the structure of molecules relates to their function and biological activity is essential in the development of new analogues with targeted activity. This is especially relevant in mediating developmental processes in mammalian cells and the regulation of stem cell differentiation. This study provides further insight into the complexity of compound design in terms of developing small molecules with specific biological activities to control the development and differentiation of mammalian cells.
Synthesis and applications of 2,4-disubstituted thiazole derivatives as small molecule modulators of cellular development
Garr-Layy Zhou, Daniel M. Tams, Todd B. Marder, Roy Valentine, Andrew Whiting and Stefan A. Przyborski
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