Suzuki coupling reactions of chloroalkylidene-β-lactones

29 Nov 2012

This paper is HOT as recommended by the referees, and is free to access for 4 weeks

Thanks to developments in new phosphine ligands the area of C–Cl bond activation has made a lot of progress.

In this paper Shengming Ma and colleagues at Zhejiang University report recent results of the Suzuki coupling reaction of optically active α-chloroalkylidene-β-lactones derivatives using a LB-Phos ligand previously developed by the group. Using this method Ma et al. have prepared a series of optically active α-alkylidene-β-lactones in high ee.

Do you think that this protocol is a versatile method for the organic community to utilise? Read the paper today and let us know by leaving your comments on this blog.