Welcome to issue 47 of Organic & Biomolecular Chemistry. So what have we got in store for you this week?
On the front cover:
In this paper by Martin F. Kreutzer and Markus Nett from the Leibniz Institute for Natural Product Research and Infection Biology, report the bioinformatic analysis of an orphan nonribosomal peptide synthetase gene cluster in the rhizobium Cupriavidus taiwanensis. This genome mining strategy led to the isolation of the associated metabolite; a previously unrecognised lipopeptide siderophore.
Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis
Martin F. Kreutzer and Markus Nett
DOI: 10.1039/C2OB26296G
On the inside cover:
This attractive image highlights the perspective of Jose M. Palomo who describes the current application of click reactions in protein chemistry, the creation of new semisynthetic enzymes by site-specific modifications and the recent design and creation of enzymes with synthetic click activities.
Click reactions in protein chemistry: from the preparation of semisynthetic enzymes to new click enzymes
Jose M. Palomo
DOI: 10.1039/C2OB26409A
Also in this issue is this HOT Communication:
Benzimidazolium-based synthetic chloride and calcium transporters in bacterial membranes
Claude-Rosny Elie, Audrey Hébert, Mathieu Charbonneau, Adam Haiun and Andreea R. Schmitzer
Read the issue today! The cover articles are free to access for 6 weeks and the HOT article is free for 4 weeks.
