The cover of this week’s issue of OBC highlights the work of Florian Hollfelder and colleagues at University of Cambridge. This HOT paper from Hollfelder et al. presents kinetic and computational evidence that hydrolytic reactions of sulfonate esters proceed with a two-step mechanism involving a pentavalent intermediate for poorer leaving groups.
Kinetic and computational evidence for an intermediate in the hydrolysis of sulfonate esters
Ann C. Babtie, Marcelo F. Lima, Anthony J. Kirby and Florian Hollfelder
DOI: 10.1039/C2OB25699A
The inside cover features the work of Lechosław Latos-Grażyński and co-workers showing that a N-confused porphyrin undergoes controlled regionselective phosphorylations at the inner, outer or both carbon atoms of the inverted pyrrole ring.
Regioselective phosphorylation and thiophosphorylation of N-confused porphyrin: a route to hybrid carbaporphyrinoids
Norbert Grzegorzek, Lechosław Latos-Grażyński and Ludmiła Szterenberg
DOI: 10.1039/C2OB26019K
Both covers are free to access for the next 6 weeks.
| Also featuring in this issue are 2 more articles marked as being HOT be the referees:
Metal-free reactions of alkynes via electrophilic iodocarbocyclizations Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine–phosphinamide bifunctional catalysts |
