Archive for July, 2012

HOT: Abnormally short Cl⋯Cl contacts inside organic crystals

This HOT Communication from Huaqiang Zeng and co-workers describes a 1D helical channel, composed of short foldamers with sticky ends that self-assemble in the solid state, that acts as a CH2Cl2 channel. What is interesting is that the Cl⋯Cl intermolecular distances within the channel are extraordinarily short. Zeng et al. perform computational modelling and calculate that this unusually short distance destabilises the host–guest complex by 14.94 kcal mol-1.

This will be free to access for the next 4 weeks so why not have a look at modelling details.

Locking high energy 1D chain of dichloromethane molecules containing abnormally short Cl⋯Cl contacts of 2.524 Å inside organic crystals
Feng Zhou, Haoliang Fu, Wei Qiang Ong, Ruijuan Ye, Weixing Yuan, Yu-Jing Lu, Yan-Ping Huo, Kun Zhang, Haibin Su and Huaqiang Zeng
DOI: 10.1039/C2OB25888A

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Submit a poster for Lipids and Membrane Biophysics: Faraday Discussion 161

There’s still just time to submit a poster for Lipids and Membrane Biophysics: Faraday Discussion 161  – by the deadline date 13 July.

This Faraday Discussion will consider recent developments in the study of biomembrane structure, ordering and dynamics, with particular emphasis on the roles of lipids in these phenomena. Registration is quick and simple via our online booking system, so act today and benefit from early bird savings.

Why choose to come to a Faraday Discussion? They have a unique format – all papers are circulated in advance and all discussion contributions are recorded for publication in the abstract book after the event. You can also have your own poster space at the meeting, so submit yours now  before the deadline of 13 July.

Come and discuss new experimental and theoretical findings and novel methodologies, as we focus on exploring the relevance of concepts from amphiphile self-assembly and soft matter physics to understanding biomembranes.

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ICPOC21: poster abstracts

There is still just time to submit your poster abstract to the 21st IUPAC International Conference on Physical Organic Chemistry (ICPOC 21) but don’t delay as the deadline is 13 July.

Register early for the best prices.

Why join ICPOC21?

Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

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Top ten most accessed articles in May

This month sees the following articles in Organic & Biomolecular Chemistry that are in the top ten most accessed:

PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes
Pei Liu, Ying-Ming Pan, Yan-Li Xu and Heng-Shan Wang
Org. Biomol. Chem., 2012, 10, 4696-4698
DOI: 10.1039/C2OB25487E

A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin–hemicyanine hybrid
Zhenghao Yang, Zhipeng Liu, Yuncong Chen, Xiaoqing Wang, Weijiang He and Yi Lu
Org. Biomol. Chem., 2012, 10, 5073-5076
DOI: 10.1039/C2OB25516B

Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids
Fangxi Xu, Dan Huang, Xufeng Lin and Yanguang Wang
Org. Biomol. Chem., 2012, 10, 4467-4470
DOI: 10.1039/C2OB25663K

One-pot synthesis of 1,2,3-triazoles from boronic acids in water using Cu(II)–ß-cyclodextrin complex as a nanocatalyst
Babak Kaboudin, Yaghoub Abedi and Tsutomu Yokomatsu
Org. Biomol. Chem., 2012, 10, 4543-4548
DOI: 10.1039/C2OB25061F

The ligand and base-free Pd-catalyzed oxidative Heck reaction of arylboronic acids and olefins
Peng Sun, Yan Zhu, Hailong Yang, Hong Yan, Linhua Lu, Xiang Zhang and Jincheng Mao
Org. Biomol. Chem., 2012, 10, 4512-4515
DOI: 10.1039/C2OB25462J

Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones
David J. Aitken, Angela M. Bernard, Francesca Capitta, Angelo Frongia, Régis Guillot, Jean Ollivier, Pier Paolo Piras, Francesco Secci and Marco Spiga
Org. Biomol. Chem., 2012, 10, 5045-5048
DOI: 10.1039/C2OB25813G

First total synthesis of (+)-indicanone
Yujiro Hayashi, Kumiko Ogawa, Fuyuhiko Inagaki and Chisato Mukai
Org. Biomol. Chem., 2012, 10, 4747-4751
DOI: 10.1039/C2OB25500F

Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct
Martin Golkowski, Carlo Pergola, Oliver Werz and Thomas Ziegler
Org. Biomol. Chem., 2012, 10, 4496-4499
DOI: 10.1039/C2OB25440A

Synthesis of diversely 1,3,5-trisubstituted pyrazoles via 5-exo-dig cyclization
Dmitry A. Borkin, Mirela Puscau, Alena Carlson, Agnes Solan, Kraig A. Wheeler, Béla Török and Roman Dembinski
Org. Biomol. Chem., 2012, 10, 4505-4508
DOI: 10.1039/C2OB25580D

Thiol–yne coupling: revisiting old concepts as a breakthrough for up-to-date applications
Alessandro Massi and Daniele Nanni
Org. Biomol. Chem., 2012, 10, 3791-3807
DOI: 10.1039/C2OB25217A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Organic & Biomolecular Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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10 of the best: Synthesis in Organic & Biomolecular Chemistry

In this addition of OBC’s ’10 of the best’ we are bringing you a selection of 10 of our most highly cited synthesis articles. As with the other blogs, every single one will be free to access for you to enjoy until July 11th.

Design, synthesis and photophysical studies of simple fluorescent anion PET sensors using charge neutral thiourea receptors
Thorfinnur Gunnlaugsson, Anthony P. Davis, Gillian M. Hussey, Juliann Tierney and Mark Glynn
DOI: 10.1039/B404706K

The small peptide-catalyzed direct asymmetric aldol reaction in water
Pawel Dziedzic, Weibiao Zou, Jonas Háfren and Armando Córdova
DOI: 10.1039/B515880J

Synthesis of protein–polymer conjugates
Karina L. Heredia and Heather D. Maynard
DOI: 10.1039/B612355D

Advanced organic synthesis using microreactor technology
Batoul Ahmed-Omer, Johan C. Brandt and Thomas Wirth
DOI: 10.1039/B615072A

Diversity-oriented synthesis; a challenge for synthetic chemists
David R. Spring
DOI: 10.1039/B310752N

Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines
Olivier Riant and Jérôme Hannedouche
DOI: 10.1039/B617746H

Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids
Henning Vogt and Stefan Bräse
DOI: 10.1039/B611091F

Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate
Thorfinnur Gunnlaugsson, Anthony P. Davis, John E. O’Brien and Mark Glynn
DOI: 10.1039/B409018G

Syntheses of polysubstituted furans: recent developments
Stefan F. Kirsch
DOI: 10.1039/B602596J

Accelerated asymmetric transfer hydrogenation of aromatic ketones in water
Xiaofeng Wu, Xiaoguang Li, William Hems, Frank King and Jianliang Xiao
DOI: 10.1039/B403627A

Missed our other 10th anniversary posts? Take a look here for more of our top cited work from the past 10 years.

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