Issue 31 online now, complete with mutant lipases & cyclic di-oxoguanidines

Organic & Biomolecular Chemistry issue 31, it’s here and waiting to be read!

Secondary alcohols having bulky substituents on both sides of the hydroxy group are inherently poor substrates for most lipases. In a paper by Tadashi Ema et al., highlighted on this week’s front cover of OBC (right), the detailed rational design and creation of mutant lipases that display remarkably enhanced catalytic activity and enantioselectivity for poor substrates bearing bulky substituents on both sides of the hydroxy group is presented.

Redesign of enzyme for improving catalytic activity and enantioselectivity toward poor substrates: manipulation of the transition state
Tadashi Ema, Yasuko Nakano, Daiki Yoshida, Shusuke Kamata and Takashi Sakai
DOI: 10.1039/C2OB25614B

The inside front cover (left) highlights the Communication of Wen-Xiong Zhang and Zhenfeng Xi et al., presenting the first metal-free one-pot sequential coupling of various amines, carbodiimides and acyl dichlorides, providing a simple and straightforward path to cyclic di-oxoguanidines via an unexpected 2,2-dichloroimidazolidindione intermediate.

Metal-free synthesis of cyclic di-oxoguanidines via one-pot sequential transformation of amines, carbodiimides and acyl dichlorides
Fei Zhao, Yang Wang, Wen-Xiong Zhang and Zhenfeng Xi
DOI: 10.1039/C2OB25799H

Both of these featured articles are FREE to access for the next 6 weeks, why not have a read and let us know your thoughts by commenting below.

 

Also in this issue:

Emerging Area
Transition metal-catalyzed fluorination of multi carbon–carbon bonds: new strategies for fluorinated heterocycles
Guosheng Liu
DOI: 10.1039/C2OB25702E

Perspective
Discovery, application and protein engineering of Baeyer–Villiger monooxygenases for organic synthesis
Kathleen Balke, Maria Kadow, Hendrik Mallin, Stefan Saß and Uwe T. Bornscheuer
DOI: 10.1039/C2OB25704A

View the complete issue online now……

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