OBC issue 27, featuring continuous-flow synthesis and core-modified porphyrins

The front cover (right) of this issue of Organic & Biomolecular Chemistry features the work Takashi Takahashi and colleagues at Tokyo Institute of Technology. Takahashi et al. present a two-stage continuous-flow synthesis of activated vitamin D3, the first application of a micro-flow system to this synthesis. The authors claim that the synthesis should be easy to scale up and that it required no purification of intermediates or high dilution conditions, and so reducing wastage.

Continuous-flow synthesis of activated vitamin D3 and its analogues
Shinichiro Fuse, Yuto Mifune, Nobutake Tanabe and Takashi Takahashi

The inside cover (left) highlights work by Chihiro Maeda and Naoki Yoshioka, Keio University, on the synthesis of peripherally ethynylated carbazole-based core-modified porphyrins. Maeda and Keio make use of a series of metal-catalyzed coupling and annulation reactions to produce the porphyrins whose π-conjugated networks are shown to effectively delocalise over the entire macrocycle.

Peripherally ethynylated carbazole-based core-modified porphyrins
Chihiro Maeda and Naoki Yoshioka

As always these cover articles are free to access for 6 weeks.

Also in this issue is this HOT communication:

First total synthesis of the biscarbazole alkaloid oxydimurrayafoline
Carsten Börger, Micha P. Krahl, Margit Gruner, Olga Kataeva and Hans-Joachim Knölker

And, the perspective ‘Strategies for the enantioselective synthesis of spirooxindoles

Find the complete issue HERE….

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