Archive for May, 2012

RSC US Roadshow 2012 – Week 4: North East

Organic & Biomolecular Chemistry Editor Richard Kelly will be visiting several North East universities next week as part of the RSC US Roadshows 2012.

Week 4 sees the Royal Society of Chemistry visiting four universities in Pennsylvania and New York:

May 7th – University of Pittsburgh
May 8th – Pennsylvania State University
May 10th – University of Pennsylvania
May 11th – Columbia University

Read more about the US roadshows 2012:

Starting in mid April 2012, RSC Publishing has been touring the United States of America to share more than 170 years experience of publishing in the chemical sciences. Sixteen universities across the country are hosting these one-day events, which are open to all members of the hosting institute.

Attendees have the opportunity to explore RSC’s apps on mobile devices and meet informally with RSC editors. Lunchtime discussion groups explore reading habits and opportunities in the 21st century and an afternoon seminar give an insight into the world of scholarly publishing, with tips on how to get published in high impact journals. A demonstration of ChemSpider, and a guest lecture from an RSC associate editor or board member are available at many of the roadshows.

Follow the RSC Roadshows on Twitter – just look for #RSC2012.

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Palladium-catalysed aminosulfonylation and the design and synthesis of screening libraries on the cover of issue 20

The covers of this week’s OBC issue are brought to you by Michael C. Willis et al. and Rohan A. Davis et al.

The front cover highlights the work of Michael C. Willis et al. who demonstrate that it is possible to construct C–SO2–N linkages using palladium-catalysed aminosulfonylation processes.

Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides
Edward J. Emmett, Charlotte S. Richards-Taylor, Bao Nguyen, Alfonso Garcia-Rubia, Barry R. Hayter and Michael C. Willis
DOI: 10.1039/C2OB07034K

The inside front cover shows work from Rohan A. Davis et al. who present the design and synthesis of two screening libraries utilising the muurolane natural product scaffold from the plant E. mitchellii.

Design and synthesis of screening libraries based on the muurolane natural product scaffold
Emma C. Barnes, Vanida Choomuenwai, Katherine T. Andrews, Ronald J. Quinn and Rohan A. Davis
DOI: 10.1039/C2OB00029F

Don’t forget, access to these cover articles is FREE for the next 6 weeks.

Also in this issue is the HOT article ‘Synthetic UDP-galactofuranose analogs reveal critical enzyme–substrate interactions in GlfT2-catalyzed mycobacterial galactan assembly‘ which was highlighted in the C&EN news story ‘Determining Sugar Sequence Fidelity‘.

Find all of issue 20 here

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Check out our Foldamer Chemistry web themed issue

The Organic & Biomolecular Chemistry web theme issue focussing on the exciting area of foldamer chemistry is now available for you to access, with 21 articles for you to read, 4 of which have so far appeared on the covers of issues.

Here are some of the popular articles that others have been reading:

Regio- and diastereoselective fluorination of alicyclic β-amino acids
Loránd Kiss, Enikő Forró, Santos Fustero and Ferenc Fülöp
Org. Biomol. Chem., 2011, 9, 6528-6534
DOI: 10.1039/C1OB05648D

Conformational stability of collagen triple helices functionalized in the Yaa position by click chemistry
Roman S. Erdmann and Helma Wennemers
Org. Biomol. Chem., 2012, 10, 1982-1986
DOI: 10.1039/C2OB06720J

Stereoselective preparation of β,γ-methano-GABA derivatives
David J. Aitken, Ludovic Drouin, Sarah Goretta, Régis Guillot, Jean Ollivier and Marco Spiga
Org. Biomol. Chem., 2011, 9, 7517-7524
DOI: 10.1039/C1OB06095C

Design and synthesis of trans-3-aminopyran-2-carboxylic acid (APyC) and α/β-peptides with 9/11-helix
Gangavaram V. M. Sharma, Kodeti Srinivas Reddy, Shaik Jeelani Basha, Kondreddi Ravinder Reddy and Akella V. S. Sarma
Org. Biomol. Chem., 2011, 9, 8102-8111
DOI: 10.1039/C1OB06279D

To read the rest of this great web themed issue… CLICK HERE

                             What do you think if this area of chemistry? Do you have a favourite article from the collection?
Let us know your thoughts by leaving a comment below.

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HOT: Critical enzyme–substrate interactions in GlfT2-catalyzed mycobacterial galactan assembly

Todd L. Lowary and colleagues at the University of Alberta, Canada, have synthesised a series of UDP-galactofuranose analogs and used these analogs to examine enzyme–substrate binding interactions for the galactofuranosyltransferase enzyme GlfT2, a glycosyltransferase responsible for the formation of the galactan complex in M. tuberculosis and a potential drug target.

Critical hydrogen bonding interactions within the active site of the mycobacterial galactofuranosyltransferase GlfT2 are revealed and it is hoped the knowledge of these specific protein-carbohydrate interactions may be explored for the development of novel inhibitors.

Selected as ‘Hot’, this article will be FREE to access for the next 4 weeks.
Why not read it now and let us know what you think by leaving a comments below!

Synthetic UDP-galactofuranose analogs reveal critical enzyme–substrate interactions in GlfT2-catalyzed mycobacterial galactan assembly
Myles B. Poulin, Ruokun Zhou and Todd L. Lowary
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB25159K, Paper

 

Todd L. Lowary’s OBC work is also highlighted in this C&EN news story ‘Determining Sugar Sequence Fidelity’

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