This review by Riccardo Amorati and Luca Valgimigli, University of Bologna, is featured in issue 21 of OBC, which can now be found online.
In this Perspective Amorati and Valgimigli summarize some recent results obtained with simplified models, which can aid in understanding the effects of non-covalent interactions, i.e. intra- and inter-molecular H-bonds, on the radical chemistry of natural phenolic and polyphenolic antioxidants.
Areas of discussion include:
Intramolecular hydrogen bonds:
Reactive OH groups as H-bond donors
Reactive OH groups as H-bond acceptor
Remote H-bond effect
Intermolecular hydrogen bonds
Reactive OH groups as H-bond donors: the “classical” kinetic solvent effect (KSE)
The remote kinetic solvent effect (RKSE)
Other solvent effects
Read this well received review today!
Modulation of the antioxidant activity of phenols by non-covalent interactions
Riccardo Amorati and Luca Valgimigli
Org. Biomol. Chem., 2012, 10, 4147-4158