OBC issue 21 has now landed, and you can find it here….
Hans-Joachim Knölker and co-workers present the stereoselective synthesis of several (25S)-dafachronic acids using an orthogonally diprotected diol as a relay compound. In addition Knölker et al. discuss the hormonal activity of the novel (25S)-dafachronic acids.
Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals
Ratni Saini, Sebastian Boland, Olga Kataeva, Arndt W. Schmidt, Teymuras V. Kurzchalia and Hans-Joachim Knölker
Org. Biomol. Chem., 2012, 10, 4159-4163
DOI: 10.1039/C2OB25394A
This impressive inside front cover highlights the work of Huaqiang Zeng et al. describing the ability of tetrabutylammonium salts to mediate an efficient mono-/di-demethylation in H-bonded macrocyclic aromatic pentamers, which occur in a chemo- and regionselective fashion.
Folding-promoted TBAX-mediated selective demethylation of methoxybenzene-based macrocyclic aromatic pentamers
Zhiyun Du, Bo Qin , Chang Sun, Ying Liu, Xi Zheng, Kun Zhang, Allan H. Conney and Huaqiang Zeng
Org. Biomol. Chem., 2012, 10, 4164-4171
DOI: 10.1039/C2OB25160D
Take a closer look at both of these articles; they’re free to access for the next 6 weeks!
