On the front cover is this HOT Emerging Areaarticle from Peter R. Schreiner and co-workers (Justus-Liebig University, Germany) who discuss quantum mechanical tunnelling and provide an overview of the importance of tunnelling in organic chemical reactions.
Discussion includes:
- a brief history of tunnelling
- hydrogen tunnelling
- carbon tunnelling
- heteroatom tunnelling
Tunnelling control of chemical reactions – the organic chemist’s perspective
David Ley, Dennis Gerbig and Peter R. Schreiner
Org. Biomol. Chem., 2012, 10, 3781-3790
DOI: 10.1039/C2OB07170C
On the inside front cover is this Communication, from Ying-Yeung Yeung and colleagues at National University of Singapore, where a facile and highly enantioselective route to 2-substituted 3-bromopyrrolidines is presented. The authors demonstrate how these can be reached via the bromo-aminocyclisation of 1,2-disubstituted olefinic amides using amino-thiocarbamates as a catalyst. This is also part of our growing Organocatalysis web collection.
A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines
Jie Chen, Ling Zhou and Ying-Yeung Yeung
Org. Biomol. Chem., 2012, 10, 3808-3811
DOI: 10.1039/C2OB25327E
Both of these cover articles will be free to access for the next 6 weeks.
Also in this issue:
A perspectiveby Alessandro Massi and Daniele Nanni:
Thiol–yne coupling: revisiting old concepts as a breakthrough for up-to-date applications
And 2 HOT articles that are still free to access for another 3 weeks
Diastereoselective alkylation reactions of 1-methylcyclohexa-2,5-diene-1-carboxylic acid
Mark C. Elliott et al.
Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents
Yihua Zhang et al.
View the entire issue HERE, it’s full of lots of great content!
