Organic & Biomolecular Chemistry Blog

On the outside front cover of this week’s issue is a hot article from Huaiqing Zhao, National University of Singapore, et al. on a series of water-binding aquafoldamers with potential use in recognizing topologically diverse larger water clusters and as synthetic water channels. This article is part of our forthcoming themed issue on Foldamer Chemistry.

Synthesis, structural investigation and computational modelling of water-binding aquafoldamers
Huaiqing Zhao, Wei Qiang Ong, Xiao Fang, Feng Zhou, Meng Ni Hii, Sam Fong Yau Li, Haibin Su and Huaqiang Zeng
DOI: 10.1039/C1OB06609A

The inside front cover is work from Jonathan Guimond-Tremblay, Université Laval, et al. on the synthesis of three monofluorinated dimyristoylphosphatidylcholine derivatives for use as probes in ¹⁹F NMR studies to study the effects of drugs and peptides on model membranes.

Synthesis and properties of monofluorinated dimyristoylphosphatidylcholine derivatives: Potential fluorinated probes for the study of membrane topology
Jonathan Guimond-Tremblay, Marie-Claude Gagnon, Jozy-Ann Pineault-Maltais, Vanessa Turcotte, Michèle Auger and Jean-François Paquin
DOI: 10.1039/C2OB06570C

The issue also includes a review on the synthesis of glycosylated (2S,5R)-hydroxylysine from Margaret Brimble and coworkers and a hot article from Valentina Cerulli et al., on a highly diastereoselective Ugi multicomponent reaction