One area of research developed in Dr James N. Wilson‘s lab at the University of Miami (Florida, USA) is aimed at elucidating the complex molecular mechanisms of intercellular communication, via the development of fluorescent analogues of neuroactive compounds.
In their latest OBC communication, Wilson et al. describe the synthesis, characterization and interaction of cell lines with novel dimeric stilbazolium-based dyes that probe the functional limit of norepinephrine transport (NET) in cells. Upon exposure to different NET proteins, these environmentally sensitive dyes turn on the fluorescence and their binding to NET can be monitored using fluorescence microscopy
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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers
Erika L. Smith, Adrienne S. Brown, Edward Adjaye-Mensah and James N. Wilson
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06796J, Communication
